Effects of quinestrol and levonorgestrel on prolactin serum concentration in lactating Mongolian gerbils (Meriones unguiculatus) and reproductive parameters of their offspring

Lv, Xiaohui; Guo, Yongwang; Shi, Dazhao

doi:10.1016/j.repbio.2012.09.005

Cited by 11 publications

(6 citation statements)

References 26 publications

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“…Therefore, the inhibition of the H−P−G axis should be the main reason for the decrease in T. In addition, progesterone and estrogen have an inhibitory effect on FSH secretion (Liu et al 2012a). Under the action of the synthetic steroids, the level of reproductive hormones was significantly reduced, consistent with the results of previous studies (Lv & Shi 2011;Lv et al 2012;Su et al 2019;Yu et al 2020). In the present study, the changes in hormone levels reflected changes in reproductive organ weight, which again confirmed the reproductive inhibitory effects of EP-1 and E in male plateau zokors.…”

Section: Structural Variation Of the Uterus And Ovarysupporting

confidence: 89%

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Antifertility effects of levonorgestrel, quinestrol, and their mixture (EP‐1) on plateau zokor in the Qinghai–Tibetan Plateau

et al. 2022

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The plateau zokor (Eospalax baileyi) is a key species in the Qinghai−Tibetan Plateau ecosystem, and fertility control could be an ideal approach to manage populations of this subterranean species. In this laboratory study, we explored the effects of the mixture of levonorgestrel and quinestrol (EP-1, 1:2), quinestrol (E), and levonorgestrel (P) on the reproductive status of plateau zokors. Groups of 5 animals of each sex were treated with different concentrations of EP-1 (1, 5, and 10 mg/kg), E (0.33, 3.3, and 6.6 mg/kg), and P (0.67, 3.35, and 6.7 mg/kg) by oral gavage over 7 successive days and killed on day 15. Body mass reduction was observed in the EP-1 and E groups. EP-1 and E significantly reduced the weight of testis and epididymis at 10 and 3.3 mg/kg, respectively. Sperm count and motility were significantly reduced by 5 mg/kg EP-1 and 0.33 mg/kg E. The levels of serum testosterone, estradiol, luteinizing hormone, and follicle stimulating hormone were significantly reduced by 5 mg/kg EP-1 and 3.3 mg/kg E. EP-1 and E significantly increased the uterine and ovarian weights at 10 and 3.3 mg/kg, respectively. In the plateau zokors, treatment with P had no influence on the reproductive status. These data demonstrate that EP-1 and E have an inhibitory effect on a range of reproductive parameters in the plateau zokors. Further assessment is required to determine the effects on breeding and recruitment in enclosure or field experiments.

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Section: Structural Variation Of the Uterus And Ovarysupporting

confidence: 89%

“…Under the action of the synthetic steroids, the level of reproductive hormones was significantly reduced, consistent with the results of previous studies (Lv & Shi 2011; Lv et al . 2012; Su et al . 2019; Yu et al .…”

Section: Discussionmentioning

confidence: 99%

Antifertility effects of levonorgestrel, quinestrol, and their mixture (EP‐1) on plateau zokor in the Qinghai–Tibetan Plateau

et al. 2022

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“…Various studies (Wang et al 2011 ; Liu et al 2012 , 2014 ; Zhang 2015 ) have demonstrated that the concentration of these fertility compounds have significant reproductive effects on male rodents, including the greater long-tailed hamster ( Tscherskia triton ), Brandt’s vole ( Lasiopodomys brandtii ), the plateau pika ( Ochotona curzoniae ) and laboratory mouse ( Mus musculus ). Although in the current study, we did not determine the effects the fertility compounds have on subsequent offspring of animals which consumed treated bait, other studies have demonstrated that offspring of mothers treated with quinestrol were infertile whereas all male and female offspring from levonorgestrel-treated mothers were fertile (Lv et al 2012 ).…”

Section: Discussionmentioning

confidence: 66%

Effect of synthetic hormones on reproduction in Mastomys natalensis

et al. 2017

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Rodent pest management traditionally relies on some form of lethal control. Developing effective fertility control for pest rodent species could be a major breakthrough particularly in the context of managing rodent population outbreaks. This laboratory-based study is the first to report on the effects of using fertility compounds on an outbreaking rodent pest species found throughout sub-Saharan Africa. Mastomys natalensis were fed bait containing the synthetic steroid hormones quinestrol and levonorgestrel, both singly and in combination, at three concentrations (10, 50, 100 ppm) for 7 days. Consumption of the bait and animal body mass was mostly the same between treatments when analysed by sex, day and treatment. However, a repeated measures ANOVA indicated that quinestrol and quinestrol + levonorgestrel treatments reduced consumption by up to 45%, particularly at the higher concentrations of 50 and 100 ppm. Although there was no clear concentration effect on animal body mass, quinestrol and quinestrol + levonorgestrel lowered body mass by up to 20% compared to the untreated and levonorgestrel treatments. Quinestrol and quinestrol + levonorgestrel reduced the weight of male rat testes, epididymis and seminal vesicles by 60–80%, and sperm concentration and motility were reduced by more than 95%. No weight changes were observed to uterine and ovarian tissue; however, high uterine oedema was observed among all female rats consuming treated bait at 8 and 40 days from trial start. Trials with mate pairing showed there were significant differences in the pregnancy rate with all treatments when compared to the untreated control group of rodents.

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“…These are stored in fatty tissue and released slowly, resulting in long-lasting effects. Quinestrol has been reported to impair reproduction in male rodents by inhibiting the release of gonadotropin release hormone (GnRH), testosterone, and spermatogenesis, thereby reducing sperm quality and quantity (Shen et al 2011;Wang et al 2011;Lv et al 2012;Fu et al 2013;Liu et al 2017). The current study is the first report on the antifertility effects of quinestrol delivered with baits on male B. bengalensis and its reversibility and rodent management evaluation under field conditions.…”

Section: Introductionmentioning

confidence: 85%

Antifertility effects of quinestrol in male lesser bandicoot rat, Bandicota bengalensis, and potential in managing rodent population under field conditions

Sidhu

Singla

2023

Integr. Zool.

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Integrating fertility control techniques using steroid hormones after lethal control can help reduce post control rebuildup of rodent populations. The current study is the first to assess the antifertility effects of quinestrol in male lesser bandicoot rat, Bandicota bengalensis which is the predominant rodent pest species in Southeast Asia. Rats in different groups were fed bait containing 0.00%, 0.01%, 0.02%, and 0.03% quinestrol for 10 days in laboratory and evaluated immediately, and 15, 30, and 60 days after treatment discontinuation for effect on reproduction and other antifertility parameters. Effect of 0.03% quinestrol treatment for 15 days was also observed in managing rodent populations in groundnut crop fields. Treatment resulted in average consumption of 19.53 ± 1.80, 67.63 ± 5.50, and 246.67 ± 1.78 mg/kg bwt active ingredient by three treated groups of rats, respectively. No reproduction was observed in female rats mated with male rats treated with 0.03% quinestrol, even 30 days after cessation of treatment. Post‐mortem examination showed a significant (P < 0.0001) effect of treatment on organ weights (testis, cauda epididymis, seminal vesicles, and prostate gland) and different sperm parameters (sperm motility, sperm viability, sperm count, and sperm abnormality) in the cauda epididymal fluid with partial reversibility after 60 days. A significant (P < 0.0001) effect of quinestrol on the histomorphology of testis and cauda epididymis was observed, suggesting its effect on spermatogenesis. Affected cell association and cell count in seminiferous tubules did not fully recover within 60 days of stopping treatment. Evaluation of the effects of quinestrol treatment in groundnut fields showed greater reductions in rodent activity in fields treated with 2% zinc phosphide followed by 0.03% quinestrol treatment as compared to fields treated with 2% zinc phosphide alone. Research concludes that quinestrol has the potential to reduce fecundity and post control rebuildup of B. bengalensis populations, but long‐term studies of the effectiveness of quinestrol under large‐scale field conditions are needed to use it as part of an integrated pest control program for rodents.

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Effects of quinestrol and levonorgestrel on prolactin serum concentration in lactating Mongolian gerbils (Meriones unguiculatus) and reproductive parameters of their offspring

Cited by 11 publications

References 26 publications

Antifertility effects of levonorgestrel, quinestrol, and their mixture (EP‐1) on plateau zokor in the Qinghai–Tibetan Plateau

Antifertility effects of levonorgestrel, quinestrol, and their mixture (EP‐1) on plateau zokor in the Qinghai–Tibetan Plateau

Effect of synthetic hormones on reproduction in Mastomys natalensis

Antifertility effects of quinestrol in male lesser bandicoot rat, Bandicota bengalensis, and potential in managing rodent population under field conditions

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