Effects of Quinoa (Chenopodium quinoa) on inflammatory mediators: a systematic review of preclinical studies

Mahdavi, Aida Malek; Javadivala, Zeinab; Khalili, Yeganeh; Khalili, Majid

doi:10.1007/s10787-022-01091-y

Cited by 5 publications

(4 citation statements)

References 44 publications

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“…Several studies explained that polyphenols are useful as support therapy of their anti-inflammatory associated with antioxidant activity, and inhibition of enzymes involved in the pro-inflammatory cytokines production in addition to activating the transcription factor that plays a main role in cellular protection against oxidative stress and inflammation (Cardozo et al, 2013;Hussain et al, 2016;Liu et al, 2020;Mahdavi et al, 2023). Quinoa seeds have been suggested as antioxidant, antidiabetic, antihypertensive, anti-obesity and anti-inflammatory (Tan et al, 2021;Ren et al, 2023).…”

Section: Immunological Responsesmentioning

confidence: 99%

“…Furthermore, quinoa saponin may be associated with the inhibition of inflammatory mediators (TNF-α, IL-1β, IL-6, and nitric oxide) overproduction, so it can prevent and treat inflammation (Lim et al, 2019;El Hazzam et al, 2020;Mahdavi et al, 2023). Ren et al (2017) illusterated that the isolated amino acid (lunasin) from quinoa exhibits anti-inflammatory activity on macrophage cells where, inhibited the up regulation of NO, TNF-α and IL-6 stimulated by lipopolysaccharide (LPS).…”

Section: Immunological Responsesmentioning

confidence: 99%

“…Quinoa seeds are gluten-free and contain high-quality protein, carbohydrates, omega-3 fatty acids, and important minerals, so quinoa is considered a "super food". Also, it contains numerous phytochemicals including polysaccharides, polyphenols such as flavonoids and phenolic acids that have been suggested to be able to modulate the inflammatory processes (Yao et al, 2014;Mahdavi et al, 2023). Quinoa protein is a good precursor of bioactive peptides which have a wide range of biological activities and exhibit beneficial features as well as antioxidants, antimicrobial, anti-inflammatory and immunoregulatory, so it offers health-promoting qualities (Lin et al, 2019;Ng and Wang, 2021;Chaudhary et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

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Physiological Responses, Oxidative Status and Productive Performance of Barki Sheep fed Dietary Addition with Quinoa Seeds and Exposed to Solar Radiation

Fouda

2024

Journal of Animal and Poultry Production

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This study aimed to detect the effect of the dietary addition of quinoa seeds to ameliorate the drastic effects of oxidative stress in Barki male sheep exposed to environmental heat stress. Total of 30 Barki ram lambs were used in the present study. Animals in shaded and unshaded (animals exposed daily to direct solar radiation in the summer) groups were randomly divided into three similsr groups (5 males each). Animals of 1 st group were fed a basal diet without quinoa seeds supplementation, while, those of 2 nd and 3 rd groups were fed diets containing 5 and 10 % quinoa seeds, respectively. Results cleared that the diet contained (10%) quinoa seeds modulated significantly (P<0.05) the increase in the thermo-respiratory responses and the observed anemia, dyslipidemia, and systemic inflammation, including blood leukocytosis, the increase in serum proinflammatory cytokines and heat shock protein-70 concentrations. Furthermore, it improved significantly the gain of body-weight and kidney functions, enhanced the blood antioxidant defense system (total antioxidant capacity, and catalase and superoxide dismutase activities) in the unshaded sheep, and protected them from oxidative stress. In conclusion, feeding on diet containing 10% of quinoa seeds was suitable and safe for sheep nutrition to efficiently alleviate the cruel effects of environmental heat stress in Barki sheep.

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Section: Immunological Responsesmentioning

confidence: 99%

Section: Immunological Responsesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Physiological Responses, Oxidative Status and Productive Performance of Barki Sheep fed Dietary Addition with Quinoa Seeds and Exposed to Solar Radiation

Fouda

2024

Journal of Animal and Poultry Production

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“…For example, extracts rich in steroidal saponins from fenugreek are noted, both in vitro and in vivo, for their hypolipidemic and antidiabetic activities [7]. On the other hand, quinoa seeds have also been extensively studied in vitro and in vivo for their anti-inflammatory effect, as shown in a recent systematic review in which saponins were studied as one of the main bioactive compounds responsible for this bioactivity [8]. We have also previously demonstrated promising results for steroidal and triterpenoid saponins from fenugreek and quinoa, respectively, in terms of their enzyme inhibitory activities and potential hypocholesterolemic, antioxidant, and prebiotic effects, among others [1,9,10].…”

Section: Introductionmentioning

confidence: 99%

Combination of Fenugreek and Quinoa Husk as Sources of Steroidal and Triterpenoid Saponins: Bioactivity of Their Co-Extracts and Hydrolysates

Cantero-Bahillo,

Navarro del Hierro,

de las Nieves Siles-Sánchez

et al. 2024

Foods

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Saponins, both steroidal and triterpenoid, exhibit distinct bioactivities. However, they are not commonly found together in natural sources; instead, sources tend to be rich in one type or another and mainly in the form of saponins rather than the sapogenin aglycones. Developing co-extracts containing both saponin or sapogenin types would be a strategy to harness their respective bioactivities, yielding multibioactive extracts. Therefore, this study evaluates the bioactivity (hypolipidemic, antioxidant, and anti-inflammatory activities) of co-extracts from fenugreek seeds (steroidal-rich saponins) and quinoa husk (triterpenoid-rich saponins), co-extracted at varying proportions, alongside their respective sapogenin-rich hydrolysates. Pancreatic lipase inhibition increased with fenugreek content in co-extracts, especially in sapogenin-rich variants. The latter substantially interfered with cholesterol bioaccessibility (90% vs. 15% in sapogenin-rich extracts). Saponin-rich co-extracts exhibited reduced cytokine release with increased fenugreek content, while sapogenin-rich counterparts showed greater reductions with higher quinoa husk content. Limited cellular antioxidant activities were observed in all extracts, with improved post-hydrolysis bioactivity. Therefore, simultaneous co-extraction of steroidal and triterpenoid sources, such as fenugreek and quinoa husk, as well as their subsequent hydrolysis, are innovative strategies for obtaining multibioactive natural extracts.

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Antioxidant components and health benefits of pigmented pseudocereals

Melini,

Melini

2024

Pigmented Grains

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Effects of Quinoa (Chenopodium quinoa) on inflammatory mediators: a systematic review of preclinical studies

Cited by 5 publications

References 44 publications

Physiological Responses, Oxidative Status and Productive Performance of Barki Sheep fed Dietary Addition with Quinoa Seeds and Exposed to Solar Radiation

Physiological Responses, Oxidative Status and Productive Performance of Barki Sheep fed Dietary Addition with Quinoa Seeds and Exposed to Solar Radiation

Combination of Fenugreek and Quinoa Husk as Sources of Steroidal and Triterpenoid Saponins: Bioactivity of Their Co-Extracts and Hydrolysates

Antioxidant components and health benefits of pigmented pseudocereals

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