Effects of Radiation Therapy for Rectal Cancer on Anorectal Function

Jorge, José Márcio Neves; Habr‐Gama, Angelita; Bustamante-Lopez, Leonardo Alfonso

doi:10.1007/978-1-4939-2217-8_10

Cited by 2 publications

(2 citation statements)

References 56 publications

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“…2,3 Nowadays, pelvic irradiation is an essential part of the curative treatment strategy of pelvic malignancies, including rectal, prostate, and cervical carcinoma. 4 One of the major limiting factors for radiotherapy is the lack of contrast in the absorption of ionizing radiation between healthy and cancerous tissues. Most current efforts to defeat this problem focus on methods which spatially conform the dose to the tumor volume through improvements in treatment planning facilities and imaging.…”

Section: Introductionmentioning

confidence: 99%

Influence of the contrast agents on treatment planning dose calculations of prostate and rectal cancers

Heydarheydari

Farshchian

Haghparast

2016

Reports of Practical Oncology & Radiotherapy

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Treatment planning CT simulation Contrast agent Prostate and rectal cancers a b s t r a c t Aim:The aim of the present study is to quantify differences in dose calculations caused by using CA and determine if the resulting differences are clinically significant.Background: The influence of contrast agents (CA) on radiation dose calculations must be taken into account in treatment planning. Materials and methods:Eleven patients with pelvic cancers were included in this study and two sets of CTs were taken for each patient (without and with CA) in the same position and coordinates. Both sets of images were transferred to the DosiSoft ISOgray treatment planning system for contouring and calculating the dose distribution and monitor units (MUs) with Collapsed Cone and Superposition algorithms, respectively. All plans were generated on pre-contrast CT and subsequently copied to the post-contrast CT. Radiation dose calculations from the two sets of CTs were compared using a paired sample t-test. Results:The results showed a statistically insignificant difference between pre-and postcontrast CT treatment plans for target volume and OARs (p > 0.05), except bladder organ in the prostate region (p < 0.05) but the relative mean dose and MU differences were less than 2% in any patient for 18 MV photon beam.Conclusions: Treatment planning on contrasted images generally showed a lower radiation dose to both target volume and OARs than plans on non-contrasted images. The results of this research showed that the small radiation dose differences between the plans for the CT scans with and without CA seem to be clinically insignificant; therefore, contrast-enhanced CT can be used for both target delineation and treatment planning of prostate and rectal cancers.

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Section: Introductionmentioning

confidence: 99%

Influence of the contrast agents on treatment planning dose calculations of prostate and rectal cancers

Heydarheydari

Farshchian

Haghparast

2016

Reports of Practical Oncology & Radiotherapy

View full text Add to dashboard Cite

show abstract

“…It has been widely described that pelvic irradiation alone negatively affects anorectal function and that anorectal function is even more affected when the anorectum is the main target of radiotherapy [25,26].…”

Section: Discussionmentioning

confidence: 99%