Effects of Radiation Therapy on the Detection of Microscopic Residual Cancer in the Surgical Bed using a Protease-activated Fluorescent Probe in a Primary Soft Tissue Sarcoma Model

Cuneo, Kyle C.; Mito, Jeffrey K.; Brigman, Brian E.; Ferrer, Jorge; Lee, C.; Eward, William C.; Carter, J.E.; Kirsch, David G.

doi:10.1016/j.ijrobp.2011.06.1300

International Journal of Radiation Oncology*Biology*Physics

2011

DOI: 10.1016/j.ijrobp.2011.06.1300

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Effects of Radiation Therapy on the Detection of Microscopic Residual Cancer in the Surgical Bed using a Protease-activated Fluorescent Probe in a Primary Soft Tissue Sarcoma Model

Kyle C. Cuneo

Jeffrey K. Mito

Brian E. Brigman

et al.

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“…Microscopic quantities of residual cancer could be detected in tumor beds consisting of skeletal muscle, and the presence of residual fluorescence corresponded to local recurrence. Resection of fluorescent tissue improved local control . A pilot clinical trial assessing the imaging system in 9 dogs with naturally occurring STS or MCT that received a commercially available imaging agent 24 hours before surgery is also reported .…”

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confidence: 99%

A Novel Imaging System Distinguishes Neoplastic from Normal Tissue During Resection of Soft Tissue Sarcomas and Mast Cell Tumors in Dogs

DeWitt

Eward

et al. 2016

Veterinary Surgery

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Objective To assess the ability of a novel imaging system designed for intraoperative detection of residual cancer in tumor beds to distinguish neoplastic from normal tissue in dogs undergoing resection of soft tissue sarcoma and mast cell tumor. Study design Non-randomized prospective clinical trial. Animals 12 dogs with soft tissue sarcoma and 7 dogs with mast cell tumor. Methods A fluorescent imaging agent that is activated by proteases in vivo was administered to the dogs 4-6 or 24-26 hours prior to tumor resection. During surgery, a handheld imaging device was used to measure fluorescence intensity within the cancerous portion of the resected specimen and determine an intensity threshold for subsequent identification of cancer. Selected areas within the resected specimen and tumor bed were then imaged, and biopsies (n=101) were obtained from areas that did or did not have a fluorescence intensity exceeding the threshold. Results of intraoperative fluorescence and histology were compared. Results The imaging system correctly distinguished cancer from normal tissue in 93/101 biopsies (92%). Using histology as the reference, the sensitivity and specificity of the imaging system for identification of cancer in biopsies were 92% and 92%, respectively. There were 10/19 (53%) dogs which exhibited transient facial erythema soon after injection of the imaging agent which responded to but not consistently prevented by intravenous diphenhydramine. Conclusion A fluorescence-based imaging system designed for intraoperative use can distinguish canine STS and MCT tissue from normal tissue with a high degree of accuracy. The system has potential to assist surgeons in assessing the adequacy of tumor resections during surgery, potentially reducing the risk of local tumor recurrence. Although responsive to antihistamines, the risk of hypersensitivity needs to be considered in light of the potential benefits of this imaging system in dogs.

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confidence: 99%

A Novel Imaging System Distinguishes Neoplastic from Normal Tissue During Resection of Soft Tissue Sarcomas and Mast Cell Tumors in Dogs

DeWitt

Eward

et al. 2016

Veterinary Surgery

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Effects of Radiation Therapy on the Detection of Microscopic Residual Cancer in the Surgical Bed using a Protease-activated Fluorescent Probe in a Primary Soft Tissue Sarcoma Model

Cited by 1 publication

References 0 publications

A Novel Imaging System Distinguishes Neoplastic from Normal Tissue During Resection of Soft Tissue Sarcomas and Mast Cell Tumors in Dogs

A Novel Imaging System Distinguishes Neoplastic from Normal Tissue During Resection of Soft Tissue Sarcomas and Mast Cell Tumors in Dogs

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