2007
DOI: 10.3748/wjg.v13.i19.2684
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Effects of radiation upon gastrointestinal motility

Abstract: neural and chemical control. Myogenic control refers to the electrical activity generated by the smooth muscle of the gut. Electrical control activity (ECA) [1][2][3][4] is the omnipresent rhythmic depolarization of the cell membranes of the smooth muscle of the small intestine. With neural or chemical stimulation, membrane depolarization exceeds an excitation threshold and a contraction results. The electrical correlate of a contraction is called electrical response activity (ERA) [1][2][3][4] . These bursts … Show more

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Cited by 29 publications
(11 citation statements)
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“…In these models, liquid diet feeding before and after surgery dramatically improved survival [36]. Since radiation is known to alter gut motility [37], [38], and the segment radiation method involves bowel handling and radiation, we believe that ileus was the likely cause of death/need for euthanasia in segment-radiated mice fed with normal chow. We did not study tissue histology in these animals due to the limited number studied under this protocol.…”
Section: Discussionmentioning
confidence: 99%
“…In these models, liquid diet feeding before and after surgery dramatically improved survival [36]. Since radiation is known to alter gut motility [37], [38], and the segment radiation method involves bowel handling and radiation, we believe that ileus was the likely cause of death/need for euthanasia in segment-radiated mice fed with normal chow. We did not study tissue histology in these animals due to the limited number studied under this protocol.…”
Section: Discussionmentioning
confidence: 99%
“…2), and might also cause cognitive impairment (Raber et al 2004, Acevedo et al 2008). (Baker et al 2011) Lower-body doses this high would result in severe prodromal emesis and diarrhea (Anno et al 1995, Otterson et al 1996), but would probably not cause acute gastrointestinal lethality (Fig 2). However, lower-body doses this high would exceed renal tolerance (Fig.…”
Section: Why Be Concerned About Organ Systems Other Than Bone Marrow?mentioning
confidence: 99%
“…Ionizing radiation causes a wide diversity of functional disorders in the small intestine, including altered motility [32,33], disrupted absorption of carbohydrates [34], amino acids and bile acids [35], and a more thrombophilic endothelium due to the induction of inflammatory cell adhesion to the endothelium [36] and increased expression of endothelial von Willebrand factor [37]. …”
Section: Pathophysiology Of Small Bowel Radiation Injurymentioning
confidence: 99%