Effects of radiotherapy and chemotherapy on lung function in patients with non–small-cell lung cancer

Gopal, Ramesh; Starkschall, George; Tucker, Susan L.; Cox, James D.; Liao, Zhongxing; Hanus, M; Kelly, James; Stevens, Craig W.; Komaki, Ritsuko

doi:10.1016/s0360-3016(03)00077-4

Cited by 64 publications

(46 citation statements)

References 31 publications

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“…These results were not explained by lower radiation doses prescribed in patients with initially compromised lung function. They are in line with those of two studies which reported no decrease in PFT values in patients with FEV 1 <50% of predicted [19,20]. The number of patients with very impaired lung function included in our study was small, and consequently studies designed to measure lung function changes in these particular patients are required.…”

Section: Discussionsupporting

confidence: 90%

“…TLC and VC showed reduction of 5 and 4%, respectively, and the mean loss of FEV 1 (-7%) and of DL CO (-11%) we observed were similar to those described at 3 and 18 months in two previous 3D-RT studies [16,17]. However, in these studies very few patients received combined chemo-radiotherapy, which has been found to increase lung toxicity compared to RT alone [18,19]. Consequently, the mean loss of lung function of our lung cancer patients, who were treated with combined modalities, can be regarded as small.…”

Section: Discussionsupporting

confidence: 86%

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Impact of 3D Conformal Radiotherapy on Lung Function of Patients with Lung Cancer: A Prospective Study

Enache¹,

Noël

Jeung³

et al. 2012

Respiration

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Background: The development of three-dimensional conformal radiotherapy (3D-RT) has enabled the restriction of the dose to normal lung, limiting radiation-induced lung injury. Objectives: This study was designed to describe the time course of lung function until 7.5 months after 3D-RT in patients with lung cancer, and assess the relationship between lung function changes and dose-volume histogram (DVH) analysis or computed tomography scan changes. Radiation doses were optimized according to recent guidelines. Methods: Sixty-five lung cancer patients treated with 3D-RT agreed to participate in this prospective, hospital-based study. Lung volumes, forced expiratory volume in 1 s (FEV₁) and diffusing capacity of the lung for carbon monoxide (DLCO) were measured before radiotherapy (RT), 10 weeks, 4 and 7.5 months after the beginning of 3D-RT. Results: Eleven lung cancer patients (17%) developed grade 2-3 respiratory symptoms after RT. At 7.5 months, vital capacity (VC) was 96 ± 2%, total lung capacity (TLC) 95 ± 2%, FEV₁ 93 ± 2% and DLCO 90 ± 2% of the initial value. Only 15% of patients showed pulmonary function reduction >20%. Patients with FEV₁ or DLCO <60% before RT did not show significant changes after RT. There were weak correlations between reduction of VC, TLC, FEV₁ or DLCO and radiation dosimetric parameters and between reduction of VC or FEV₁ and radiation-induced pneumonitis images. Conclusions: In lung cancer, the reduction of lung function within 7.5 months after 3D-RT was small and correlated, albeit weakly, with DVH parameters. Patients with initially impaired lung function showed tiny changes in spirometry and DLCO values.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 86%

Impact of 3D Conformal Radiotherapy on Lung Function of Patients with Lung Cancer: A Prospective Study

Enache¹,

Noël

Jeung³

et al. 2012

Respiration

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show abstract

“…Chemotherapy and radiotherapy induced pulmonary toxicity that deteriorate a DLCO has been reported in NSCLC (26,27). The addition of chemotherapy to RT significantly exacerbates the decrease of DLCO in NSCLC (28). However, in our study, the Cox regression analysis failed to show that a low DLCO is an independent factor for mortality.…”

Section: Discussioncontrasting

confidence: 72%

A lower level of forced expiratory volume in one second predicts the poor prognosis of small cell lung cancer

et al. 2018

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“…Similar results were demonstrated by Ming et al in a prospective study in which pre-and postradiotherapy lung perfusion examinations (SPECT) and respiratory function tests (RFT), as well as changes in the lung function of 53 patients who received radiotherapy after being diagnosed with lung cancer, breast cancer and lymphoma were assessed (Fan et al, 2001). Gopal et al assessed the effects of thoracic radiotherapy and different chemotherapy combinations by RFT performed before and after radiotherapy, and demonstrated that respiratory function deteriorated with treatment (Gopal et al, 2003). In these studies, respiratory function was assessed using pre-and post-treatment controls.…”

Section: Discussionmentioning

confidence: 99%

Effects of Definitive Chemoradiotherapy on Respiratory Function Tests and Quality of Life Scores During Treatment of Lung Cancer

Duman¹,

Kaya²,

Öztürk³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Effects of radiotherapy and chemotherapy on lung function in patients with non–small-cell lung cancer

Cited by 64 publications

References 31 publications

Impact of 3D Conformal Radiotherapy on Lung Function of Patients with Lung Cancer: A Prospective Study

Impact of 3D Conformal Radiotherapy on Lung Function of Patients with Lung Cancer: A Prospective Study

A lower level of forced expiratory volume in one second predicts the poor prognosis of small cell lung cancer

Effects of Definitive Chemoradiotherapy on Respiratory Function Tests and Quality of Life Scores During Treatment of Lung Cancer

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