Effects of Ramadan fasting on platelet reactivity in diabetic patients treated with clopidogrel

Bouida, Wahid; Baccouche, Houda; Sassi, Mouna; Dridi, Zohra; Chakroun, Tahar; Hellara, Ilhem; Boukef, Riadh; Hassine, Mohsen; Added, Faouzi; Razgallah, Rabie; Khochtali, I.

doi:10.1186/s12959-017-0138-0

Cited by 6 publications

(6 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also, the relatively few MACEs in our study could be explained by the inhibited sympathetic tone during RF [13] and the limitation on smoking during Ramadan [14]. Bouida et al found that RF was significantly associated with diminished platelet sensitivity to clopidogrel in diabetic patients during and shortly after Ramadan [15]. This potential adverse effect of RF was not clinically evident in our study, mostly because we excluded most diabetic patients (uncontrolled DM, IDDM, and those with significant renal impairment).…”

Section: Discussionmentioning

confidence: 52%

The safety of Ramadan Fasting following Percutaneous Coronary Intervention

Amin

Alaarag

2020

BMC Cardiovasc Disord

View full text Add to dashboard Cite

Background This work aimed to assess the safety of Ramadan Fasting following the Percutaneous Coronary Intervention. Methods In our two centers’ Prospective Cohort Study, We included 303 patients who had successful Percutaneous Coronary Intervention before the first day of Ramadan. We advised the patients that recent Percutaneous Coronary Intervention could be a valid excuse for not fulfilling Ramadan Fasting. However, many patients intended to fast the following Ramadan, and we included them in the fasting Group I. We added the patients who decided not to fast the following Ramadan as a control Group II. We followed all the patients during Ramadan and for 6 months after Ramadan. Results The demographic data of both groups and the complexity of the coronary anatomy showed no statistically significant difference. Group I (n = 153) showed a statistically significant difference in the incidence of Major Adverse Cardiac Events compared to Group II with a P value (0.005). The logistic multivariate regression analysis showed that the duration from index PCI till the start of RF, SYNTAX score > 22, and Complex procedure were independent predictors of Major Adverse Cardiac Events in the fasting Group I with {P = 0.001, OR (2.302), P = 0.026, OR (2.419), and P = 0.032 OR (1.952)}, respectively. Major Adverse Cardiac Events in Group I occurred mainly during Ramadan Fasting, with 19 patients having Major Adverse Cardiac Events during Ramadan and four patients during the remaining of the follow-up period. The Receiver Operating Characteristic curve analysis showed the decline of the incidence of Major Adverse Cardiac Events after 90 days from Percutaneous Coronary Intervention till the start of Ramadan Fasting with Sensitivity and specificity (90% and 65%), respectively. Conclusions We suggest that low-risk patients with a normal systolic function who underwent Percutaneous Coronary Intervention may safely fast Ramadan. At the same time, Ramadan Fasting during the first 3 months following the Percutaneous Coronary Intervention may not be safe.

show abstract

Section: Discussionmentioning

confidence: 52%

The safety of Ramadan Fasting following Percutaneous Coronary Intervention

Amin

Alaarag

2020

BMC Cardiovasc Disord

View full text Add to dashboard Cite

show abstract

“…In patients with T2 diabetes, dehydration can present as low blood pressure, lethargy, syncope, haemoconcentration and hypercoagulability predisposing to thrombosis [84] and strokes [85]. Although fasting can reduce platelet sensitivity to clopidogrel in T2 diabetes, this may be related to an increase in glycaemia during Ramadan [86]. However, it has been reported that the incidence of acute cardiac illness in patients with T2 diabetes is not different during Ramadan than at other times [87].…”

Section: Dehydration Thrombosis and Macrovascular Riskmentioning

confidence: 99%

Ramadan and Diabetes: A Narrative Review and Practice Update

et al. 2020

View full text Add to dashboard Cite

Fasting in the Islamic month of Ramadan is obligatory for all sane, healthy adult Muslims. The length of the day varies significantly in temperate regions-typically lasting C 18 h during peak summer in the UK. The synodic nature of the Islamic calendar means that Ramadan migrates across all four seasons over an approximately 33-year cycle. Despite valid exemptions, there is an intense desire to fast during this month, even among those who are considered to be at high risk, including many individuals with diabetes mellitus. In this review we explore the current scientific and clinical evidence on fasting in patients with diabetes mellitus, focussing on type 2 diabetes mellitus and type 1 diabetes mellitus, with brief reviews on pregnancy, pancreatic diabetes, bariatric surgery, the elderly population and current practice guidelines. We also make recommendations on the management of diabetes patients during the month of Ramadan.

show abstract

“…However, a few studies showed no changes or even an increase in these parameters ( 10 – 17 ). Moreover, none of the studies showing reductions in these parameters considered potential confounders that may have affected their findings or explained the observed changes ( 13 , 14 , 18 – 20 ) and none targeted the general population.…”

Section: Introductionmentioning

confidence: 99%

The impact of Ramadan intermittent fasting on anthropometric measurements and body composition: Evidence from LORANS study and a meta-analysis

et al. 2023

View full text Add to dashboard Cite

BackgroundAlthough the effect of Ramadan intermittent fasting (RIF) on anthropometry and body composition has been questioned, none of the previous studies tried to explain the reported changes in these parameters. Also, systematic reviews that investigated the topic were limited to healthy individuals or a specific disease group.MethodsThe London Ramadan Study (LORANS) is an observational study on health effects of RIF. We measured weight, waist circumference (WC), hip circumference (HC), body mass index (BMI), waist-to-hip ratio (WHR), basal metabolic rate (BMR), fat percentage (FP), free-fat mass (FFM), extremities predicted muscle mass, total body water (TBW), trunk FM, trunk FFM and trunk predicted muscle mass before and immediately after Ramadan. Using mixed-effects regression models, we investigated the effect of RIF with adjustment for potential confounders. We also conducted a meta-analysis of the results of LORANS with other studies that investigated the effect of RIF on anthropometry and body composition. The review protocol is registered with PROSPERO registry (CRD42020186532).ResultsWe recruited 146 participants (Mean ± SD age = 43.3 ± 15 years). Immediately after Ramadan, compared with before Ramadan, the mean difference was−1.6 kg (P<0.01) in weight,−1.95cm (P<0.01) in WC,−2.86cm (P <0.01) in HC, −0.60 kg/m2 (P < 0.01) in BMI and −1.24 kg (P < 0.01) in FM. In the systematic review and meta-analysis, after screening 2,150 titles and abstracts, 66 studies comprising 7,611 participants were included. In the general population, RIF was followed by a reduction of 1.12 Kg in body weight (−1.89– −0.36, I2 = 0), 0.74 kg/m2 reduction in BMI (−0.96– −0.53, I2 = 0), 1.54cm reduction in WC (−2.37– −0.71, I2 = 0) and 1.76cm reduction in HC (−2.69– −0.83, I2 = 0). The effect of fasting on anthropometric and body composition parameters starts to manifest in the second week of Ramadan and starts to diminish 3 weeks after Ramadan.ConclusionRIF is associated with a reduction in body weight, BMI, WC, HC, FM, FP and TBW. Most of these reductions are partially attributed to reduced FM and TBW. The reductions in these parameters appear to reverse after Ramadan.

show abstract

Effects of Ramadan fasting on platelet reactivity in diabetic patients treated with clopidogrel

Cited by 6 publications

References 29 publications

The safety of Ramadan Fasting following Percutaneous Coronary Intervention

The safety of Ramadan Fasting following Percutaneous Coronary Intervention

Ramadan and Diabetes: A Narrative Review and Practice Update

The impact of Ramadan intermittent fasting on anthropometric measurements and body composition: Evidence from LORANS study and a meta-analysis

Contact Info

Product

Resources

About