Effects of Ranibizumab combined with laser photocoagulation on macular volume and best corrected visual acuity in patients with macular edema secondary to ischemic retinal vein occlusion

Abstract

Objective: To investigate the effects of ranibizumab combined with laser photocoagulation on macular volume and best corrected visual acuity (BCVA) in patients with macular edema secondary to ischemic retinal vein occlusion.
 Methods: The clinical data of 90 patients (90 eyes) with macular edema secondary to ischemic retinal vein occlusion treated in our hospital from June 2018 to December 2021 were retrospectively analyzed. Patients were divided into Groups-A, B, and C according to the type of treatment they received. The Group-A was treated with laser photocoagulation, the Group-B was intravitreally injected with ranibizumab, and the Group-C underwent ranibizumab combined with laser photocoagulation. The efficacy, intraocular pressure, BCVA, central macular thickness (CMT) and adverse reactions were compared among the three groups.
 Results: The total efficacy of the Group-C was higher than that of the Group-A and B, with statistically significant differences (P< 0.05). Three months after treatment, BCVA was higher while CMT was reduced in the Group-C than those in the Group-A and B (P < 0.05). Six months after treatment, BCVA was higher while intraocular pressure was lower and CMT was thinner in the group C compared with the Group-A and B (P< 0.05).
 Conclusions: Ranibizumab combined with laser photocoagulation in the treatment of macular edema secondary to ischemic retinal vein occlusion presents significant efficacy, and can effectively reduce macular volume, improve visual acuity and promote the recovery of retinal function.
 doi: https://doi.org/10.12669/pjms.39.2.7040
 How to cite this: Liang J, Xiong T, Chen H, Tao R, Cao L. Effects of Ranibizumab combined with laser photocoagulation on macular volume and best corrected visual acuity in patients with macular edema secondary to ischemic retinal vein occlusion. Pak J Med Sci. 2023;39(2):---------. doi: https://doi.org/10.12669/pjms.39.2.7040
 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Efficacy and Safety of Laser Therapy on Ischemic Central Retinal Vein Occlusion: A Systematic Review and Analysis of Clinical Studies

“…Despite its utility, the efficacy of laser photocoagulation in improving visual acuity in CRVO has been limited, contrasting its more pronounced benefits in cases of branch retinal vein occlusion (BRVO) [5,6]. The advent of pharmacological interventions, notably anti-VEGF agents, has heralded a paradigm shift in treatment approaches, offering new avenues for addressing the underlying pathophysiological mechanisms of CRVO [7][8][9].…”

“…The evolution of treatment strategies from laser photocoagulation to include anti-VEGF therapies reflects a nuanced understanding of CRVO's multifactorial nature. Recent investigations into combination therapies, such as ranibizumab with laser photocoagulation, underscore an ongoing quest to optimize therapeutic outcomes by enhancing macular volume and best-corrected visual acuity [7]. This systematic review seeks to elucidate laser therapy's comparative effectiveness and safety against a backdrop of rapidly evolving pharmacologic treatments, with a particular focus on anti-VEGF modalities.…”