Effects of Ranolazine on Vasomotor Responses of Rat Aortic Rings

Effects of Ranolazine on Noninvasive Coronary Flow Reserve in Patients with Myocardial Ischemia But without Obstructive Coronary Artery Disease

“…A modulation of diastolic activation of contractile proteins, which can reduce wall tension and consequently extravascular compression of intramural vessels, may justify decreased baseline coronary flow velocity, while the effects on hyperemic diastolic flow velocity, still unknown, could be linked to other mechanism, as the synthesis/release of nitric oxide by the endothelium, that was recently demonstrated in rats. 14 Our data seem to be different to those recently published by Villano et al, who found, in patients with microvascular angina, that symptoms, time to 1-mm ST-segment depression, and exercise stress test duration were improved by ranolazine compared with placebo, while no effects on coronary microvascular function and on flow-mediated dilation were observed. 10…”

Late sodium channel blockade improves angina and myocardial perfusion in patients with severe coronary microvascular dysfunction: Women's Ischemia Syndrome Evaluation–Coronary Vascular Dysfunction ancillary study

“…By blocking the late sodium channel current, ranolazine leads to decreased intracellular calcium, which reduces diastolic dysfunction, leading to improved myocardial blood flow and decreased angina. Other proposed mechanisms of action of ranolazine include nitric oxide-mediated vasodilation effect [28], anti-inflammatory effects [29], and myocardial metabolic shifts [30]. Identification of treatment targets for CMD is important, as patients with persistent angina and signs of ischemia remain at elevated risk for adverse outcomes despite no obstructive CAD [19].…”

A TTX‐Sensitive Resting Na+ Permeability Contributes to the Catecholaminergic Automatic Activity in Rat Pulmonary Vein

“…Third, ranolazine reversed the vasoconstriction of isolated rings of rat aorta induced by cirazoline (n = 4), in agreement with previously published results on rat aortic rings precontracted with phenylephrine. 18,19…”