Effects of rare earth doping on multi-core iron oxide nanoparticles properties

Petran, Anca; Radu, Teodora; Borodi, Gheorghe; Nan, Alexandrina; Suciu, Maria; Turcu, Rodica

doi:10.1016/j.apsusc.2017.09.160

Cited by 25 publications

(19 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The iron oxide nanoparticles, i.e., ferrimagnetic maghemite (γ-Fe 2 O 3 ) with Fe 3+ vacancies and ferrimagnetic magnetite (Fe 3 O 4 ≡ FeO•Fe 2 O 3 ) with Fe 2+ and Fe 3+ vacancies, have already been applied in the field of medicine due to their biocompatibility, biodegradability, and possibility to tailor magnetic behavior (Sangaiya and Jayaprakash, 2018), where the change of nanoparticle size, morphology, agglomeration, magnetic, and electronic properties influences the biological effect (Liu et al, 2016). Although magnetic targeting iron nanoparticles serve as platforms for attaching drugs like, e.g., doxorubicin (DOX), they were also applied in a tumor therapy, which resulted in a hyperthermia and oxidative stress leading to tumor cell damage (Rangam et al, 2017; Petran et al, 2018; Sangaiya and Jayaprakash, 2018). Enhancement of antitumor effect was obtained by functionalization of nanoparticles by a conventional DOX drug (Liu et al, 2016; Rangam et al, 2017) and/or doping with rare metals (Petran et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…Although magnetic targeting iron nanoparticles serve as platforms for attaching drugs like, e.g., doxorubicin (DOX), they were also applied in a tumor therapy, which resulted in a hyperthermia and oxidative stress leading to tumor cell damage (Rangam et al, 2017; Petran et al, 2018; Sangaiya and Jayaprakash, 2018). Enhancement of antitumor effect was obtained by functionalization of nanoparticles by a conventional DOX drug (Liu et al, 2016; Rangam et al, 2017) and/or doping with rare metals (Petran et al, 2018). Additional functionalization of iron nanoparticles may lead to enhancement of their biocompatibility, colloidal stability, and enlargement of number of groups, through which the required antitumor effect can be obtained.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Surface Study of Fe3O4 Nanoparticles Functionalized With Biocompatible Adsorbed Molecules

et al. 2019

View full text Add to dashboard Cite

Surfaces of iron oxide of ferrimagnetic magnetite (Fe3O4) nanoparticles (MNPs) prepared by Massart's method and their functionalized form (f-MNPs) with succinic acid, L-arginine, oxalic acid, citric acid, and glutamic acid were studied by dynamic light scattering (DLS), Fourier transform infrared spectroscopy (FTIR-S), UV-vis, thermogravimetric analysis (TGA)/differential scanning calorimetry (DSC), X-ray photoelectron spectroscopy (XPS), and reflection electron energy loss spectroscopy (REELS). The XPS analysis of elements and their chemical states at the surface of MNPs and f-MNPs revealed differences in chemical bonding of atoms, content of carbon–oxygen groups, iron oxide forms, iron oxide magnetic properties, adsorbed molecules, surface coverage, and overlayer thickness, whereas the Auger parameters (derived from XPS and Auger spectra) and elastic and inelastic scattering probabilities of electrons on atoms and valence band electrons (derived from REELS spectra) indicated modification of surface charge redistribution, electronic, and optical properties. These modified properties of f-MNPs influenced their biological properties. The surfaces biocompatible for L929 cells showed various cytotoxicity for HeLa cells (10.8–5.3% of cell death), the highest for MNPs functionalized with oxalic acid. The samples exhibiting the largest efficiency possessed smaller surface coverage and thickness of adsorbed molecules layers, the highest content of oxygen and carbon–oxygen functionalizing groups, the highest ratio of lattice O2− and OH− to C sp2 hybridizations on MNP surface, the highest ratio of adsorbed O− and OH− to C sp2 hybridizations on adsorbed molecule layers, the closest electronic and optical properties to Fe3O4, and the lowest degree of admolecule polymerization. This high cytotoxicity was attributed to interaction of cells with a surface, where increased content of oxygen groups, adsorbed O−, and OH− may play the role of additional adsorption and catalytic sites and a large content of adsorbed molecule layers of carboxylic groups facilitating Fenton reaction kinetics leading to cell damage.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Surface Study of Fe3O4 Nanoparticles Functionalized With Biocompatible Adsorbed Molecules

et al. 2019

View full text Add to dashboard Cite

show abstract

“…8 Particles of various spinel ferrites can now be routinely prepared using the coprecipitation method by partial or complete replacement of Fe 2+ ions in magnetite (Fe 3 O 4 ) nanocrystals with other divalent transition metal ions (Co 2+ , Ni 2+ , Mn 2+ ) 4,[9][10][11] or with lanthanide ions (Gd 3+ , Eu 3+ , Dy 3+ ). 7,[12][13][14][15][16] In the case of Co, it is incorporated by partial or complete replacement of Fe 2+ ions in magnetite (Fe 3 O 4 ) nanocrystals. 4,9,[17][18] The complete replacement of Fe 2+ gives rise to cobalt ferrite that exhibits a cubic spinel structure with a ferromagnetic nature, [19][20] along with interesting electronic, magnetic, optic and catalytic properties.…”

Section: Introductionmentioning

confidence: 99%

Doped-Iron Oxide Nanocrystals Synthesized by One-Step Aqueous Route for Multi-Imaging Purposes

et al. 2019

View full text Add to dashboard Cite

New doped inorganic nanocrystals (NC) consisting on iron oxide and other metal integrated into the structure have been synthesized in one-step by adapting the oxidant precipitation synthesis route for magnetite. Different metals have been chosen to confer extra and unique properties to the resulting magnetic heteronanostructure: Co and Gd for enhancing transversal and longitudinal relaxivities for Magnetic Resonance Imaging (MRI), and Bi and Au for achieving X-Ray absorption for CT imaging. Apart of that, gold optical properties are interesting for photothermal therapy and iron oxides for magnetic hyperthermia. All metals have been incorporated during the synthesis to the magnetite structure in different ways: by forming a solid solution, by modifying the surface of the NCs or by cocrystallization with the magnetite. The nanostructure formed in each case depends on the ionic radius of the secondary metal ion and the solubility of its hydroxide that control the co-precipitation in the initial steps of the reaction.Magnetic properties and imaging capabilities of the heteronanostructures have been analyzed as a function of the element distribution. Due to the synergistic combination of the different element properties, these magnetic heteronanostructures have great potential for biomedical applications.

show abstract

“…A very interesting prospect is to enhance their size-dependent properties like low toxicity, facile synthesis [ 24 ], surface-to-volume ratio, superparamagnetism [ 25 , 26 ] and affect the magnetic interactions through doping the core of nanoparticles with different metal ions. Usually transition metals are effective dopants, changing the magnetic properties of iron oxide nanoparticles [ 27 , 28 ]. Whilst doping of magnetite with lanthanides such as Ho, Gd, Tb, as well as other metals, e.g., Re, Y, is common and simple in principle, establishing the synthesis procedure with controlled shape, size and magnetic properties is difficult [ 10 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Easy Synthesis and Characterization of Holmium-Doped SPIONs

et al. 2018

View full text Add to dashboard Cite

The exceptional magnetic properties of superparamagnetic iron oxide nanoparticles (SPIONs) make them promising materials for biomedical applications like hyperthermia, drug targeting and imaging. Easy preparation of SPIONs with the controllable, well-defined properties is a key factor of their practical application. In this work, we report a simple synthesis of Ho-doped SPIONs by the co-precipitation route, with controlled size, shape and magnetic properties. To investigate the influence of the ions ratio on the nanoparticles’ properties, multiple techniques were used. Powder X-ray diffraction (PXRD) confirmed the crystallographic structure, indicating formation of an Fe3O4 core doped with holmium. In addition, transmission electron microscopy (TEM) confirmed the correlation of the crystallites’ shape and size with the experimental conditions, pointing to critical holmium content around 5% for the preparation of uniformly shaped grains, while larger holmium content leads to uniaxial growth with a prism shape. Studies of the magnetic behaviour of nanoparticles show that magnetization varies with changes in the initial Ho3+ ions percentage during precipitation, while below 5% of Ho in doped Fe3O4 is relatively stable and sufficient for biomedicine applications. The characterization of prepared nanoparticles suggests that co-precipitation is a simple and efficient technique for the synthesis of superparamagnetic, Ho-doped SPIONs for hyperthermia application.

show abstract

Effects of rare earth doping on multi-core iron oxide nanoparticles properties

Cited by 25 publications

References 34 publications

Surface Study of Fe3O4 Nanoparticles Functionalized With Biocompatible Adsorbed Molecules

Surface Study of Fe3O4 Nanoparticles Functionalized With Biocompatible Adsorbed Molecules

Doped-Iron Oxide Nanocrystals Synthesized by One-Step Aqueous Route for Multi-Imaging Purposes

Easy Synthesis and Characterization of Holmium-Doped SPIONs

Contact Info

Product

Resources

About