Effects of RAS inhibitors on all-site cancers and mortality in the Hong Kong diabetes surveillance database (2002-2019)

Yang, Aimin; Wu, Hongjiang; Lau, Eric S. H.; Shi, Mai; Fan, Baoqi; Kong, Alice Pik‐Shan; Ching‐Wan, Ronald; Luk, Andrea O. Y.; Chan, Juliana C.N.; Chow, Elaine

doi:10.1016/j.ebiom.2022.104219

Cited by 8 publications

(8 citation statements)

References 52 publications

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“…Previous studies regarding Raf-1/MEK1/2/ERK1/2-mediated signaling pathway have focused mainly on the regulation of various cancers such as liver, kidney, and breast. [37,38] The relationship between Raf-1/MEK1/2/ERK1/2 pathway and hyperglycemia, if any, remains to be investigated. Our cellular and animal data demonstrated that Raf-1/MEK1/2/ERK1/2 pathway was significantly elevated in the IR HepG2 cells and T2DM mice.…”

Section: Discussionmentioning

confidence: 99%

Enhanced Hypoglycemic Bioactivity via RAS/Raf‐1/MEK/ERK Signaling Pathway by Combining Capsaicin and QUERCETIN from Chili Peppers

Zhu

Zhang

et al. 2023

Molecular Nutrition Food Res

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Scope: This research work is designed and conducted to explore the joint effect of capsaicin and quercetin and the potential mechanism for the regulation of hyperglycemia. Methods and results: Insulin-resistance HepG2 cell model and high-fat diet combined with streptozotocin-induced type 2 diabetes mouse model are applied for the investigation. The results illustrate that capsaicin and quercetin can exert hypoglycemic effects via reducing the concentrations of serum lipids of total cholesterol, triglyceride and low-density lipoprotein cholesterol, decreasing hepatic enzyme activities of phosphoenolpyruvate, carboxykinase, and glucose-6-phosphatase, as well as improving the histopathological morphology of liver and pancreas tissues. After administration with capsaicin and quercetin, the relative protein expression abundance of Ras, Raf-1, MEK1/2, and ERK1/2 is obviously attenuated compared to diabetic mice. Capsaicin and quercetin at a ratio of 3:1 are generally determined as the optimal combination. Conclusion: Capsaicin and quercetin present in the chili pepper fruit can act in a synergistic way to alleviate hyperglycemia. This study provides supporting data for the discovery of novel anti-diabetic components and for the valorization of chili pepper industry.

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Section: Discussionmentioning

confidence: 99%

Enhanced Hypoglycemic Bioactivity via RAS/Raf‐1/MEK/ERK Signaling Pathway by Combining Capsaicin and QUERCETIN from Chili Peppers

Zhu

Zhang

et al. 2023

Molecular Nutrition Food Res

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“…Time-varying exposure to RASi and other medications were based on start and end dates of dispensing records within each follow-up year for each patient. 21 Prior treatment duration with each medication was defined based on start and end dates of dispensing records to the index date. We converted the daily dose of ACEi/ARBs into lisinopril-dose equivalent for each patient ( Table S3 ), 22 and calculated the time-weighted mean daily RASi dose based on the mean daily dose dispensed during the follow-up period.…”

Section: Methodsmentioning

confidence: 99%

Clinical outcomes following discontinuation of renin-angiotensin-system inhibitors in patients with type 2 diabetes and advanced chronic kidney disease: a prospective cohort study

Yang¹,

Shi²,

Lau³

et al. 2023

eClinicalMedicine

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“…85 A recently completed cohort study from Hong Kong including 253 491 patients with T2D showed that RAAS blocker use was independently associated with lower cancer risk, with stronger associations in users of ARB than ACEI. 86 Other studies have investigated the association between RAAS blockers and risk of specific types of cancer; and a case control study from Spain has suggested that ACEI have a protective effect on colorectal cancer, especially in males under 65 years. 87 The association between RAAS blockers and risk of lung cancer is controversial.…”

Section: Raas and Systemic Inflammationmentioning

confidence: 99%

Beyond blood pressure, fluid and electrolyte homeostasis – Role of the renin angiotensin aldosterone system in the interplay between metabolic diseases and breast cancer

Kalupahana,

Moustaid‐Moussa

2024

Acta Physiologica

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The classical renin angiotensin aldosterone system (RAAS), as well as the recently described counter‐regulatory or non‐canonical RAAS have been well characterized for their role in cardiovascular homeostasis. Moreover, extensive research has been conducted over the past decades on both paracrine and the endocrine roles of local RAAS in various metabolic regulations and in chronic diseases. Clinical evidence from patients on RAAS blockers as well as pre‐clinical studies using rodent models of genetic manipulations of RAAS genes documented that this system may play important roles in the interplay between metabolic diseases and cancer, namely breast cancer. Some of these studies suggest potential therapeutic applications and repurposing of RAAS inhibitors for these diseases. In this review, we discuss the mechanisms by which RAAS is involved in the pathogenesis of metabolic diseases such as obesity and type‐2 diabetes as well as the role of this system in the initiation, expansion and/or progression of breast cancer, especially in the context of metabolic diseases.

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Effects of RAS inhibitors on all-site cancers and mortality in the Hong Kong diabetes surveillance database (2002-2019)

Cited by 8 publications

References 52 publications

Enhanced Hypoglycemic Bioactivity via RAS/Raf‐1/MEK/ERK Signaling Pathway by Combining Capsaicin and QUERCETIN from Chili Peppers

Enhanced Hypoglycemic Bioactivity via RAS/Raf‐1/MEK/ERK Signaling Pathway by Combining Capsaicin and QUERCETIN from Chili Peppers

Clinical outcomes following discontinuation of renin-angiotensin-system inhibitors in patients with type 2 diabetes and advanced chronic kidney disease: a prospective cohort study

Beyond blood pressure, fluid and electrolyte homeostasis – Role of the renin angiotensin aldosterone system in the interplay between metabolic diseases and breast cancer

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