Effects of Red Palm Oil on Myocardial Antioxidant Enzymes, Nitric Oxide Synthase and Heart Function in Spontaneously Hypertensive Rats

Katengua-Thamahane, Emma; Bacova, Barbara Szeiffova; Bernátová, Iveta; Sýkora, Matúš; Knézl, V.; Rooyen, Jacques Van; Tribulová, Narcis

doi:10.3390/ijms18112476

Cited by 5 publications

(2 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Two recent studies by Bacova et al and Katengua-Thamahane et al are found using spontaneously hypertensive rats SHR as subjects to study the effects of using RPO on the myocardial antioxidant enzyme, heart function and nitric oxide synthase 43,44 . Both results reported that with 0.2 mL of RPO supplementation per day for continuously 5 weeks had resulted in a significant reduction of elevated blood pressure and total NOS activity.…”

Section: Increase Antioxidant Level and Reduce Risk Of Cancermentioning

confidence: 99%

Red Palm Oil: A Review on Processing, Health Benefits and Its Application in Food

et al. 2021

View full text Add to dashboard Cite

IntroductionOil palm, Elaeis guineensis, has been cultivated in Malaysia since 1917 and is now the most important economic crop in Malaysia, with export revenue from the crop reaching more than RM 67.12 billion in 2018 1 . Other leading palm oil-producing countries are Indonesia and Thailand. The crop produces almost ten times higher oil per hectare than any other leading vegetable oil crops 2 . Palm oil and its derivatives are mainly used for cooking, frying oils, margarine, shortenings, vanaspati and specialty fats 3 . Palm oil or its blends with with palm kernel or with other vegetable oils were the different product available in market.Crude palm oil is extracted from palm mesocarp and rich in minor components, including carotenoids precursor of vitamin A , tocopherols and tocotrienols vitamin E , sterols, phospholipids, squalene, aliphatic hydrocarbons and aliphatic alcohols 4 . More research has been focusing on carotenoids and vitamin E in palm oil in recent years with its antioxidant properties. Despite their nutritional values, palm carotenoids are removed during the refining process, this is to gain clear oil which is better for consumer acceptance and industry purposes 5 . The concentration of carotenoids is reduced to more than half with application of high temperature and steps such as deacidification and deodorization. Goh et al. stated that tocopherols level

show abstract

Section: Increase Antioxidant Level and Reduce Risk Of Cancermentioning

confidence: 99%

Red Palm Oil: A Review on Processing, Health Benefits and Its Application in Food

et al. 2021

View full text Add to dashboard Cite

show abstract

“…It has been well established that the modulation of membrane channel protein “connexin 43” (Cx43), the most abundant connexin in the heart [98], could have various cardioprotective effects [99,100,101,102]. The association of six subunits of Cx43 results in the formation of hemichannel “connexon” [103].…”

Section: Involvement Of Mitochondrial Connexin 43 In Cardioprotectionmentioning

confidence: 99%

Myocardial Adaptation in Pseudohypoxia: Signaling and Regulation of mPTP via Mitochondrial Connexin 43 and Cardiolipin

Ferko

Andelova

Bačová

et al. 2019

Cells

View full text Add to dashboard Cite

Therapies intended to mitigate cardiovascular complications cannot be applied in practice without detailed knowledge of molecular mechanisms. Mitochondria, as the end-effector of cardioprotection, represent one of the possible therapeutic approaches. The present review provides an overview of factors affecting the regulation processes of mitochondria at the level of mitochondrial permeability transition pores (mPTP) resulting in comprehensive myocardial protection. The regulation of mPTP seems to be an important part of the mechanisms for maintaining the energy equilibrium of the heart under pathological conditions. Mitochondrial connexin 43 is involved in the regulation process by inhibition of mPTP opening. These individual cardioprotective mechanisms can be interconnected in the process of mitochondrial oxidative phosphorylation resulting in the maintenance of adenosine triphosphate (ATP) production. In this context, the degree of mitochondrial membrane fluidity appears to be a key factor in the preservation of ATP synthase rotation required for ATP formation. Moreover, changes in the composition of the cardiolipin’s structure in the mitochondrial membrane can significantly affect the energy system under unfavorable conditions. This review aims to elucidate functional and structural changes of cardiac mitochondria subjected to preconditioning, with an emphasis on signaling pathways leading to mitochondrial energy maintenance during partial oxygen deprivation.

show abstract

Metabolite profile and gene expression of the roots of oil palm seedlings treated with Hendersonia GanoEF1 and infected with Ganoderma boninense

et al. 2021

View full text Add to dashboard Cite

Effects of Red Palm Oil on Myocardial Antioxidant Enzymes, Nitric Oxide Synthase and Heart Function in Spontaneously Hypertensive Rats

Cited by 5 publications

References 50 publications

Red Palm Oil: A Review on Processing, Health Benefits and Its Application in Food

Red Palm Oil: A Review on Processing, Health Benefits and Its Application in Food

Myocardial Adaptation in Pseudohypoxia: Signaling and Regulation of mPTP via Mitochondrial Connexin 43 and Cardiolipin

Metabolite profile and gene expression of the roots of oil palm seedlings treated with Hendersonia GanoEF1 and infected with Ganoderma boninense

Contact Info

Product

Resources

About