Effects of red wine and wine polyphenol resveratrol on platelet aggregation in vivo and in vitro

Abstract-Recent research focuses on health benefits of phytochemicals, especially antioxidant and antimicrobial properties of phenolic compounds, which is known to exert preventive activity against infectious and degenerative diseases, inflammation and allergies via antioxidant, antimicrobial and proteins/enzymes neutralization/modulation mechanisms. Phenolic compounds are reactive metabolites in a wide range of plant-derived foods and mainly divided in four groups: phenolic acids, flavonoids, stilbenes and tannins. They work as terminators of free radicals and chelators of metal ions that are capable of catalyzing lipid oxidation. Therefore, this review examines the functional properties of phenolics.

show abstract

“…In addition, recent studies show that resveratrol sustains healthy nerves and important brain functions including cognitive processes [43]- [46].…”

Section: Polyphenols In Healthmentioning

confidence: 99%

Phenolics in Human Health

Özcan¹,

Akpinar‐Bayizit²,

Yilmaz‐Ersan³

et al. 2014

IJCEA

200

135

View full text Add to dashboard Cite

show abstract

“…However, RS has been shown to inhibit the aggregation of platelets (Bertelli et al, 1996b;Bhat et al, 2001;Fan et al, 2008). Suppression of platelet aggregation by RS in rabbits supplemented with hypercholesterolemic diet and reduced atherosclerosis in genetic hypercholesterolemic mice were also demonstrated (Zini et al, 1999;Wang et al, 2002b). However, RS failed to demonstrate such effects in whole blood as the mechanism might be through inhibition of mitogen-activated protein kinases in platelets (Kirk et al, 2000).…”

Section: Suppression Of Platelet Aggregation By Rsmentioning

confidence: 99%

“…However, various other studies have failed to show a change in lipids and lipoprotein profile after treatment with RS in vivo (Wilson et al, 1996;Soleas et al, 1997;Turrens et al, 1997Turrens et al, , 1999Fremont, 2000;Wang et al, 2002b). Table 1 shows a list of studies analysing the effects of RS on lipid and lipoprotein levels in various experimental conditions.…”

Section: Effect Of Rs On Lipids and Lipoprotein Levelsmentioning

confidence: 99%

Anti-atherogenic effects of resveratrol

Ramprasath

Jones

2010

Eur J Clin Nutr

View full text Add to dashboard Cite

Resveratrol (RS), a polyphenol compound found in grapes and grape products, including wine, peanuts and berries, exists in cis-and trans-isomeric forms. RS is believed to decrease circulating low-density lipoprotein cholesterol levels and reduce cardiovascular disease (CVD) risk. However, it is possible that RS has other mechanisms to reduce the risk of CVD without altering lipid levels. The objective of this review is to critically examine results from recent research concerning potential effects of RS on CVD. RS exerts several health benefits including anti-atherogenic, anti-inflammatory and anti-cancer effects. RS may also prevent lipid oxidation, platelet aggregation, arterial vasodilation and modulates the levels of lipids and lipoproteins. As a potent, anti-oxidant RS reduces oxidative stress and regenerates a-tocopherol, which further strengthens the anti-oxidant defense mechanism. RS has been considered safe as no significant toxic effects have been identified, even when consumed at higher concentrations. This evidence identified RS as an effective anti-atherogenic agent, which could be used in the prevention and treatment of CVD.

show abstract

“…Studies in animals and humans have suggested that RW and RW polyphenols may improve lipid profiles, reduce platelet aggregation, reduce endothelial dysfunction and improve blood pressure; however, their effect on arterial stiffness remains to be further investigated (Goldberg et al, 1996;Diebolt et al, 2001;Wang et al, 2002;Ralay Ranaivo et al, 2004). To date, one study has investigated the effects of RW polyphenols (7alcohol) on arterial stiffness (Mahmud and Feely, 2002).…”

Section: Introductionmentioning

confidence: 99%

The effect of chronic consumption of red wine polyphenols on vascular function in postmenopausal women

et al. 2006

View full text Add to dashboard Cite

Objective: To elucidate whether the chronic consumption of dealcoholised red wine (DRW) (polyphenol-rich component) and/ or red wine (RW) improves vascular function in hypercholesterolaemic postmenopausal women. Design, subjects and intervention: A randomised parallel-arm study. Forty-five hypercholesterolaemic postmenopausal women were randomised into either water, DRW or RW group for 6 weeks following a 4 week washout. Fasting measures of central haemodynamic parameters, arterial wave reflection and endothelial nitric oxide were taken at 0 and 6 weeks. Setting: Clinic in the School of Public Health, Curtin University. Results: There were no significant between group differences in arterial stiffness as measured by augmentation index (AIx) and augmentation pressure (AP). However, a significant within group decrease in AIx (À9%, P ¼ 0.02) and AP (À12%, P ¼ 0.02) was observed following DRW consumption. No significant changes were observed in central haemodynamic parameters and endothelial nitric oxide levels following DRW and RW consumption, compared to water. Conclusions: Neither the chronic consumption of DRW nor RW improved markers of arterial stiffness, compared to control. However, the significant within group improvements in these indices following the consumption of DRW cannot be overlooked and warrant further investigation.

show abstract

Effects of red wine and wine polyphenol resveratrol on platelet aggregation in vivo and in vitro

Cited by 160 publications

References 12 publications

Phenolics in Human Health

Phenolics in Human Health

Anti-atherogenic effects of resveratrol

The effect of chronic consumption of red wine polyphenols on vascular function in postmenopausal women

Contact Info

Product

Resources

About