Effects of red wine polyphenolic compounds on paraoxonase-1 and lectin-like oxidized low-density lipoprotein receptor-1 in hyperhomocysteinemic mice

Noll, Christophe; Hamelet, Julien; E, Matulewicz; Paul, Jean–Louis; Delabar, Jean–Maurice; Janel, Nathalie

doi:10.1016/j.jnutbio.2008.06.002

Cited by 54 publications

(33 citation statements)

References 46 publications

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“…The CBS activatory capacity was previously found in catechin and wind polyphenols [14,15]. In this study, after Sal A treatment, elevated plasma homocysteine levels and reduced hepatic cysteine concentrations returned toward normal when the activities of CBS and CSE were increased in hyperlipidemic rats.…”

Section: Discussionsupporting

confidence: 71%

“…Retrospective studies have demonstrated that some beneficial polyphenols have the capacity to increase the activity of CBS [14,15]. Salvianolic acid A (Sal A), an aqueous extract from salvia miltiorrhiza , has been shown to present wide cardioprotective effects in myocardial ischemia, endothelial dysfunction and diabetes with most of the beneficial effects being related to its antioxidant capacity in vivo [16-18].…”

Section: Introductionmentioning

confidence: 99%

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Activation of transsulfuration pathway by salvianolic acid a treatment: a homocysteine-lowering approach with beneficial effects on redox homeostasis in high-fat diet-induced hyperlipidemic rats

Zhang

Wang

et al. 2013

Nutr Metab (Lond)

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BackgroundElevated homocysteine is a cardiovascular risk factor in hyperlipidemia. Transsulfuration pathway provides an endogenous pathway for homocysteine conversion to antioxidant glutathione (GSH). Salvianolic acid A (Sal A) contains two molecules of caffeic acid and one molecule of danshensu that is capable of enhancing homocysteine transsulfuration, which led to the hypothesis that Sal A has activatory effect on transsulfuration pathway and this effect may have beneficial effects on both homocysteine and redox status in hyperlipidemia.Methods and resultsTo test this hypothesis, we developed a rat model of hyperlipidemia induced by high-fat diet for 16 weeks, during which rats were treated with 1 mg/kg salvianolic acid A (Sal A) for the final 4 weeks. Activities of key enzymes and metabolite profiling in the transsulfuration pathway revealed that hyperlipidemia led to elevated plasma homocysteine levels after 16-week dietary treatment, which was associated with reduced activities of homocysteine transsulfuration enzymes, cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE). The impaired transsulfuration pathway prevented homocysteine transsulfuration to cysteine, resulting in cysteine deficiency and subsequent reduction in GSH pool size. The redox status was altered in the setting of hyperlipidemia as indicated by GSH/GSSG ratio. Sal A treatment increased hepatic CBS and CSE activities, which was associated with reduced accumulation in circulating homocysteine levels and attenuated decline in hepatic cysteine content in hyperlipidemic rats. Sal A also led to an increase in GSH pool size, which subsequently caused a restored GSH/GSSG ratio. The activatory effect of Sal A on CBS was also observed in normal rats and in in vitro experiment.ConclusionOur results suggest that activation of transsulfuration pathway by Sal A is a promising homocysteine-lowering approach that has beneficial effects on redox homeostasis in hyperlipidemic settings.

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Section: Discussionsupporting

confidence: 71%

Section: Introductionmentioning

confidence: 99%

Activation of transsulfuration pathway by salvianolic acid a treatment: a homocysteine-lowering approach with beneficial effects on redox homeostasis in high-fat diet-induced hyperlipidemic rats

Zhang

Wang

et al. 2013

Nutr Metab (Lond)

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“…PE treatment also resulted in a drastic reduction in plasma Hcy levels and in aortic expression of proinflammatory cytokines and adhesion molecules. (248). The phytoalexin resveratrol, which is considered to be the main mediator of the beneficial effect of wine (117,265), has been shown to display antioxidant, antiplatelet, and antiinflammatory effects, inhibit lipid peroxidation, and decrease serum triglycerides and LDL levels in vivo (233,265).…”

Section: E Dietary Factors and Lifestyle Factorsmentioning

confidence: 99%

The Human Paraoxonase Gene Cluster As a Target in the Treatment of Atherosclerosis

She

Chen

Yan

et al. 2012

Antioxidants & Redox Signaling

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The paraoxonase (PON) gene cluster contains three adjacent gene members, PON1, PON2, and PON3. Originating from the same fungus lactonase precursor, all of the three PON genes share high sequence identity and a similar b propeller protein structure. PON1 and PON3 are primarily expressed in the liver and secreted into the serum upon expression, whereas PON2 is ubiquitously expressed and remains inside the cell. Each PON member has high catalytic activity toward corresponding artificial organophosphate, and all exhibit activities to lactones. Therefore, all three members of the family are regarded as lactonases. Under physiological conditions, they act to degrade metabolites of polyunsaturated fatty acids and homocysteine (Hcy) thiolactone, among other compounds. By detoxifying both oxidized low-density lipoprotein and Hcy thiolactone, PONs protect against atherosclerosis and coronary artery diseases, as has been illustrated by many types of in vitro and in vivo experimental evidence. Clinical observations focusing on gene polymorphisms also indicate that PON1, PON2, and PON3 are protective against coronary artery disease. Many other conditions, such as diabetes, metabolic syndrome, and aging, have been shown to relate to PONs. The abundance and/or activity of PONs can be regulated by lipoproteins and their metabolites, biological macromolecules, pharmacological treatments, dietary factors, and lifestyle. In conclusion, both previous results and ongoing studies provide evidence, making the PON cluster a prospective target for the treatment of atherosclerosis. Antioxid. Redox Signal. 16, 597-632.

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“…Hitherto, the efficacy of flavonoids has been shown against different diseases including diabetes, cancers, and cardiovascular diseases (23). Flavonoids exert their beneficial effects via different mechanisms including antioxidant and hypocholesterolemic activities as well as modulatory effects on various cell signaling pathways and gene expression (24)(25)(26)(27).…”

Section: Flavonoidsmentioning

confidence: 99%

The Protective Role of Phenolic Compounds Against Doxorubicin-induced Cardiotoxicity: A Comprehensive Review

Razavi-Azarkhiavi

Iranshahy

Sahebkar

et al. 2016

Nutrition and Cancer

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Although doxorubicin (DOX) is among the most widely used anticancer agents, its clinical application is hampered owing to its cardiotoxicity. Adjuvant therapy with an antioxidant has been suggested as a promising strategy to reduce DOX-induced adverse effects. In this context, many phenolic compounds have been reported to protect against DOX-induced cardiotoxicity. The cardioprotective effects of phenolic compounds are exerted via multiple mechanisms including inhibition of reactive oxygen species generation, apoptosis, NF-κB, p53, mitochondrial dysfunction, and DNA damage. In this review, we present a summary of the in vitro, in vivo, and clinical findings on the protective mechanisms of phenolic compounds against DOX-induced cardiotoxicity.

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Effects of red wine polyphenolic compounds on paraoxonase-1 and lectin-like oxidized low-density lipoprotein receptor-1 in hyperhomocysteinemic mice

Cited by 54 publications

References 46 publications

Activation of transsulfuration pathway by salvianolic acid a treatment: a homocysteine-lowering approach with beneficial effects on redox homeostasis in high-fat diet-induced hyperlipidemic rats

Activation of transsulfuration pathway by salvianolic acid a treatment: a homocysteine-lowering approach with beneficial effects on redox homeostasis in high-fat diet-induced hyperlipidemic rats

The Human Paraoxonase Gene Cluster As a Target in the Treatment of Atherosclerosis

The Protective Role of Phenolic Compounds Against Doxorubicin-induced Cardiotoxicity: A Comprehensive Review

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