Effects of reduced glutathione on stress and inflammatory response in Korean native calves vaccinated with foot-and-mouth disease vaccine

Cha, Chun-Nam; Chae, Won Seok; Yoo, Chang-Yeul; Son, Song-Ee; Kim, Suk; Lee, Hu-Jang

doi:10.13041/jpvm.2018.42.1.37

Cited by 1 publication

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“…GSH works mainly as an antioxidant defense mechanism and is involved in nutrient metabolism, protein synthesis, and the regulation of other cellular events in human and animals [12]. It was confirmed that the inoculation of the vaccine with GSH was effective for the reduction of stress and inflammatory response in calves [13]. And, the effect of GSH in the antioxidant system has been investigated in environmental and chemically stressed fish [14], and the influence of increased temperature on the levels of GSH in multiple tissues has been reported [15].…”

Section: Introductionmentioning

confidence: 88%

Glutathione Injection Alleviates the Fluctuation of Metabolic Response under Thermal Stress in Olive Flounder, Paralichthys olivaceus

Kim

et al. 2019

Metabolites

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Continuous increases in water temperature disturb homeostasis and increase oxidative stress in fish. Glutathione (GSH) is an intracellular antioxidant that helps to relieve stress in animals. In this study, we observed the effect of GSH on olive flounder exposed to high temperature using serum parameters and NMR-based metabolomics. Based on the results from the first experiment, 20 mg of GSH was chosen as an effective dose with lower infection rates and mortality. Then, fish were divided into Control, Temp (PS injection), and GSH (glutathione injection) groups, and fish in Temp and GSH groups were exposed to temperature fluctuations (20 °C→24 °C→27 °C). In OPLS-DA score plots, Temp group was clearly distinguished from the other groups in the kidney. In the liver, the metabolic patterns of GSH group were close to the Temp group on day 4 and became similar to Control group from day 7. Serum parameters did not change significantly, but the deviation in Temp group was greater than that in GSH group. Metabolite levels that were significantly altered included GSH, lactate, O-phosphocholine, and betaine in the kidney and taurine, glucose, and several amino acids in the liver, which were related to antioxidant activity and energy system. Therefore, GSH supplements could relieve thermal stress influencing metabolic mechanisms in fish.

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Section: Introductionmentioning

confidence: 88%

Glutathione Injection Alleviates the Fluctuation of Metabolic Response under Thermal Stress in Olive Flounder, Paralichthys olivaceus

Kim

et al. 2019

Metabolites

View full text Add to dashboard Cite

show abstract

Effects of reduced glutathione on stress and inflammatory response in Korean native calves vaccinated with foot-and-mouth disease vaccine

Cited by 1 publication

References 10 publications

Glutathione Injection Alleviates the Fluctuation of Metabolic Response under Thermal Stress in Olive Flounder, Paralichthys olivaceus

Glutathione Injection Alleviates the Fluctuation of Metabolic Response under Thermal Stress in Olive Flounder, Paralichthys olivaceus

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