Effects of regular endurance exercise on GlycA: Combined analysis of 14 exercise interventions

Barber, Jacob L.; Kraus, William E.; Church, Timothy S.; Hagbèrg, James M.; Thompson, Paul D.; Bartlett, David B.; Beets, Michael W.; Earnest, Conrad P.; Huffman, Kim M.; Landers‐Ramos, Rian Q.; Leon, Arthur S.; Rao, D. C.; Seip, Richard L.; Slentz, Cris A.; Wilund, Kenneth R.; Bouchard, Claude; Sarzynski, Mark A.

doi:10.1016/j.atherosclerosis.2018.07.029

Cited by 13 publications

(9 citation statements)

References 36 publications

(48 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One study mentioned above with a 6-month intervention of resistance exercise alone or combined with diet in overweight and pre-diabetes individuals showed that GlycA levels decreased significantly by 2% [136]. Barber et al demonstrated significantly reduced plasma GlycA in 1568 individuals submitted to 14 exercise interventions even after adjustment for age, sex, race, baseline BMI, and baseline GlycA [137].…”

Section: Effect Of Exercisementioning

confidence: 99%

Title: Human Serum/Plasma Glycoprotein Analysis by 1H-NMR, an Emerging Method of Inflammatory Assessment

Fuertes-Martín

Correig

Vallvé

et al. 2020

JCM

View full text Add to dashboard Cite

Several studies suggest that variations in the concentration of plasma glycoproteins can influence cellular changes in a large number of diseases. In recent years, proton nuclear magnetic resonance (1H-NMR) has played a major role as an analytical tool for serum and plasma samples. In recent years, there is an increasing interest in the characterization of glycoproteins through 1H-NMR in order to search for reliable and robust biomarkers of disease. The objective of this review was to examine the existing studies in the literature related to the study of glycoproteins from an analytical and clinical point of view. There are currently several techniques to characterize circulating glycoproteins in serum or plasma, but in this review, we focus on 1H-NMR due to its great robustness and recent interest in its translation to the clinical setting. In fact, there is already a marker in H-NMR representing the acetyl groups of the glycoproteins, GlycA, which has been increasingly studied in clinical studies. A broad search of the literature was performed showing a general consensus that GlycA is a robust marker of systemic inflammation. The results also suggested that GlycA better captures systemic inflammation even more than C-reactive protein (CRP), a widely used classical inflammatory marker. The applications reviewed here demonstrated that GlycA was potentially a key biomarker in a wide range of diseases such as cancer, metabolic diseases, cardiovascular risk, and chronic inflammatory diseases among others. The profiling of glycoproteins through 1H-NMR launches an encouraging new paradigm for its future incorporation in clinical diagnosis.

show abstract

Section: Effect Of Exercisementioning

confidence: 99%

Title: Human Serum/Plasma Glycoprotein Analysis by 1H-NMR, an Emerging Method of Inflammatory Assessment

Fuertes-Martín

Correig

Vallvé

et al. 2020

JCM

View full text Add to dashboard Cite

show abstract

“…Contrary to findings by Dethlefsen et al [19], we observed lower levels of the chronic inflammatory marker GlycA in CLL-FIT patients and slower in vitro cell growth. GlycA is robustly modifiable by exercise training and is lower in those with higher cardiorespiratory fitness [49,50]. As such, the role inflammation plays on cancer cell growth is complex, and the inflammatory response to exercise which promotes higher physical fitness are equally complex in the cancer setting.…”

Section: Cell Growth In Autologous Plasmamentioning

confidence: 99%

Higher Physical Fitness Regulates In Vitro Tumor Cell Growth in Older Adults with Treatment Naïve Chronic Lymphocytic Leukemia (CLL)

Sitlinger

Garcia

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

Chronic lymphocytic leukemia (CLL) is associated with physical dysfunction and low overall fitness that predicts poor survival following commencement of treatment. However, it remains unknown whether higher fitness in CLL patients provides anti-oncogenic effects. We identified ten fit (CLL-FIT) and ten less fit (CLL-UNFIT) treatment-naive CLL patients from 144 CLL patients who completed a set of physical fitness and performance tests. Patient plasma was used to determine its effects on in vitro 5-day growth/viability of three B-cell cell lines (OSU-CLL, Daudi and Farage). Plasma exosomal miRNA profiles, circulating lipids, lipoproteins, inflammation levels, and immune cell phenotypes were also assessed. CLL-FIT was associated with fewer viable OSU-CLL cells at Day 1 (p=0.003), Day 4 (p=0.001) and Day 5 (p=0.009). No differences between groups were observed for Daudi and Farage cells. Of 455 distinct exosomal miRNAs identified, 32 miRNAs were significantly different between groups. Of these, 14 miRNAs had ≤-1 or ≥1 log2 fold differences. CLL-FIT patients had 5 exosomal miRNAs with lower expression and 9 miRNAs with higher expression. CLL-FIT patients had higher HDL cholesterol, lower inflammation, and lower levels of triglyceride components (all p<0.05). CLL-FIT patients had lower frequencies of low-differentiated NKG2+/CD158a/bneg (p=0.015 and p=0.014) and higher frequencies of NKG2Aneg/CD158b+ mature NK-cells (p=0.047). Absolute numbers of lymphocytes including CD19+/CD5+ CLL-cells were similar between groups (p=0.359). Higher physical fitness in CLL patients is associated with altered CLL-like cell line growth in vitro, and with altered circulating and cellular factors indicative of better immune functions and tumor control.

show abstract

“…Several studies have shown that exercise on a regular basis can change gene expression in various tissues and strengthen the body's protective mechanisms (5). Exercise is able to positively regulate glycoprotein (6).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Endurance Training on Fibronectin Gene Expression of the Sciatic Nerve in Diabetic Rats

Hamed¹,

Gharakhanlou²,

Peeri³

2020

ACTA

View full text Add to dashboard Cite

- Diabetic neuropathy can cause disorders in axon transmission, changes in the extracellular matrix, and peripheral nerve damages. However, its mechanism, along with the beneficial effects of exercise on these disorders is not entirely clear. The aim of the current study was to assess changes in fibronectin mRNA gene expression level of the sciatic nerve in rats with streptozotocin-induced diabetes after endurance training. Eighteen male Wistar rats (10 weeks old with 250±20 gr weight) were randomly assigned to three groups, including healthy, induced diabetes and induced diabetes plus endurance training. Induction of diabetes was conducted using an intraperitoneal injection of a single dose of streptozotocin (STZ). Neuropathy was confirmed using the behavioral tests. Rats in induced diabetes plus training group had 8 weeks of moderate and increasing intensity endurance training on the treadmill. The Fibronectin mRNA gene expression level of the sciatic nerve was assessed using Real-time-PCR. Changes in fibronectin protein and myelin thickness were measured by immunohistochemistry and luxol fast blue staining. The mean and standard deviation was used to report descriptive data. Data were entered into SPSS 22. Fibronectin mRNA gene expression level (1.90) of sciatic nerve fibronectin protein and myelin thickness reduced significantly due to diabetes (P<0.05). Eight weeks of endurance training increased fibronectin gene expression of sciatic nerve fibronectin protein and prevented further destruction of myelin, which was statistically significant. The results showed that diabetes leads to changes in the extracellular matrix and the reduction of the sciatic nerve myelin thickness. Endurance training as a non-drug strategy is effective in preventing these damages.

show abstract

Effects of regular endurance exercise on GlycA: Combined analysis of 14 exercise interventions

Cited by 13 publications

References 36 publications

Title: Human Serum/Plasma Glycoprotein Analysis by 1H-NMR, an Emerging Method of Inflammatory Assessment

Title: Human Serum/Plasma Glycoprotein Analysis by 1H-NMR, an Emerging Method of Inflammatory Assessment

Higher Physical Fitness Regulates In Vitro Tumor Cell Growth in Older Adults with Treatment Naïve Chronic Lymphocytic Leukemia (CLL)

The Effect of Endurance Training on Fibronectin Gene Expression of the Sciatic Nerve in Diabetic Rats

Contact Info

Product

Resources

About