Effects of Regular Recreational Exercise Training on Serum ANGPTL3-Like Protein and Lipid Profile in Young Healthy Adults

Abstract

Evidence of the role of ANGPTL3, a liver-secreted glycoprotein, in serum lipid turnover, led us to hypothesize that this protein may be involved in modification of the lipid profile induced by exercise-training. Given the lack of data regarding this issue, the main goal of the present study was to investigate the effects of regular participation in a recreational physical activity program on serum ANGPTL3 and selected lipid profile measures in young, apparently healthy female and male adults. We compared serum ANGPTL3, lipid profile measures, common lipid ratios, the Atherogenic Index of Plasma (AIP) and glucose in fasting blood samples derived from 22 active physical education students including active females (AF, N=6) and males (AM, N=16) with samples from 28 relatively sedentary age-matched peers, including female (SF, N=9) and male (SM, N=19) individuals not involved in any regular physical conditioning program. Despite high inter-individual variability of serum ANGPTL3, there was a general tendency toward higher serum ANGPTL3 and HDL-C in women compared to men, but without significant differences related to their physical activity status. Based on both routine lipid profile measures and lipid ratios, all participants had normal lipid profiles, normal glycemia, as well as favorable anthropometric indices not suggesting increased cardiometabolic risk. However, lower levels of the TG/HDL-C ratio and AIP in physically active compared to relatively sedentary participants, reflecting the predominance of large, buoyant LDL particles, strongly support the view of beneficial health-promoting effects of regular participation in recreational sport activities.

Differential Expression of the Host Lipid Regulators ANGPTL-3 and ANGPTL-4 in HCV Infection and Treatment

“…Correlation and regression analyses (see Table 5 and Table 6 ) showed that patient gender and age may be associated, to some extent, with ANGPTL-3 and ANGPTL-4 levels during HCV infection or after HCV eradication. Such relationships have been described in studies concerning healthy populations [ 76 , 77 ]. They may be due to the higher activity of target lipases LPL and HL seen in women or reflect inherent changes in lipid metabolism occurring with age [ 78 ].…”

Effects of exercise training on ANGPTL3/8 and ANGPTL4/8 and their associations with cardiometabolic traits

“…To our knowledge, the impact of acute exercise or chronic exercise on ANGPTL3 expression has not been studied. A cross-sectional study of 22 physically active students and 28 age-matched sedentary students found no difference in serum ANGPTL3 between the groups ( 51 ).…”

Targeting angiopoietin‐like 3 in atherosclerosis: From bench to bedside

“…Physical activity No significant differences were observed related to physical activity status. 48 Serum ANGPTL3 levels are not influenced by physical activity status.…”

“…36 Sex Women have higher serum ANGPTL3 compared with men. 48 Serum ANGPTL3 levels have high inter-individual variability.…”