Effects of renin and ACTH on adrenal steroid secretion in the American bullfrog

Johnston, C. I.; Davis, JO; Wright, Fay; Ss, Howards

doi:10.1152/ajplegacy.1967.213.2.393

Cited by 85 publications

(21 citation statements)

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“…The observed decrease in aldosterone secretion with ACTH-suppressive doses of dexamethasone suggest that the frog's endogenous ACTH supports aldosterone secretion in vivo. Although intramuscular ACTH did not significantly increase plasma aldosterone in a bled, pithed preparation of Rana catesbeiana, an intravenous infusion of the peptide did increase the plasma level in dexamethasone-treated animals (10).…”

Section: Discussionmentioning

confidence: 70%

“…Corticosterone is secreted by the bullfrog (10), but it is not clear whether the steroid functions as a glucocorticoid in this species or is released from the interrenal as an aldosterone biogenetic precursor. Frog renin increased the plasma level of both steroids (10) in Rana catesbeiana, but a saline environment decreased the peripheral plasma level of aldosterone but not that of corticosterone in Bufo marinus (24).…”

Section: Discussionmentioning

confidence: 86%

“…A saline infusion failed to decrease plasma aldosterone in a pithed preparation of Rana catesheiana (10). Blood loss and dexamethasone treatment may account for the conflicting result in the latter report (10).…”

Section: Discussionmentioning

confidence: 94%

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Metabolism and rate of secretion of aldosterone in the bullfrog

Ulick¹,

Feinholtz²

1968

J. Clin. Invest.

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A study of the metabolism of aldosterone in the bullfrog was undertaken to provide a measurable metabolite for the indirect isotope dilution technique for measuring secretory rates. The rate of excretion of labeled aldosterone was considerably slower in the frog than in man and made necessary the collection of excretory products for 5 days to insure reasonably complete recovery of metabolites. The major identifiable metabolite was a tetrahydro derivative subsequently identified as 3,f-hydroxy-5,8-tetrahydroaldosterone. This metabolite was excreted partly in the free form and partly as a glucuronic acid conjugate. The pH 1-hydrolyzable conjugate of aldosterone was not detected.For the measurement of secretory rates, aldosterone-3H was injected into the dorsal lymph space and the animal placed in a bath to provide an environment of constant electrolyte composition and intake and a means of collecting excretory products. Urine and bath fluid were collected for 5 days, tetrahydroaldosterone was isolated, and its specific activity determined for the calculation of the aldosterone secretory rate. The rate of secretion of aldosterone in the bullfrog was increased by a tap water bath and by bovine adrenocorticotropic hormone, decreased by a saline bath and by dexamethasone, and unchanged by valine-5-angiotensin amide.

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Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 86%

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Metabolism and rate of secretion of aldosterone in the bullfrog

Ulick¹,

Feinholtz²

1968

J. Clin. Invest.

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“…Corticosterone and aldosterone are the major corticosteroids secreted by the adrenal glands of many species of amphibians, reptiles and birds, including the American bullfrog, Rana catesbeiana (Carstensen et al 1959(Carstensen et al , 1961Ulick & Solomon, 1960 ;Ulick & Kusch, 1960 ;Nicolis & Ulick, 1965 ;Macchi & Phillips, 1966 ;Psychoyos et al 1966;Johnston et al 1967;Ulick & Feinholtz, 1968), the leopard frog, R. pipiens (Kraulis & Birmingham, 1964), the edible frog, R. rugulosa (Chan et al 1969), the marine toad, Bufo marinus (Crabbé, 1963(Crabbé, , 1966, the turtles, Pseudemys cripta elegans, Chrysemys pietà pietà (Sandor, Lamoureux & Lanthier, 1965;Macchi & Phillips, 1966) and Emys orbicularis (Macchi & Phillips, 1966), the snakes, Natrix natrix (Phillips, Chester Jones & Bellamy, 1962) and Naja naja (Huang et al 1969) the chicken, Gallus domesticus (de Roos & de Roos, 1963Hall & Koritz, 1966) the gull, Larus argentatus (Macchi & Brown, 1964) and the duck Anas platyrhynchos (Sandor & Lanthier, 1963;Macchi & Brown, 1964;Whitehouse & Vinson, 1967). The present study shows that the major corticosteroids produced by the adrenal of Xenopus in vitro are aldosterone, 18-hydroxycorticosterone, corticosterone and 11-deoxycorticosterone.…”

Section: Discussionmentioning

confidence: 99%

“…Species investigated include Rana catesbeiana (Carstensen, Burgers & Li, 1959, 1961Ulick & Solomon, 1960;Ulick & Kusch, 1960;Nicolis & Ulick, 1965;Psychoyos, Tallan & Greengard, 1966;Macchi & Phillips, 1966;Ulick & Feinholtz, 1968), Bufo marinus (Crabbé, 1963(Crabbé, , 1966, Rana pipiens (Kraulis & Birmingham, 1964) and Rana rugulosa (Chan, Vinson & Phillips, 1969). Stimulation by mammalian corticotrophin (ACTH) of the production of corticosterone and aldosterone has been shown in R. catesbeiana both in vitro (Carstensen et al 1959(Carstensen et al ,1961Macchi & Phillips, 1966) and in vivo (Johnston, Davis, Brown, Wright & Howard, 1966; Johnston, Davis, Wright & Howard, 1967).…”

Section: Introductionmentioning

confidence: 99%

Kinetic Studies on the Biosynthesis of Corticosteroids in Vitro From Exogenous Precursors by the Interrenal Glands of the Normal, Corticotrophin-Treated and Adenohypophysectomized Xenopus Laevis Daudin

Chan¹,

Edwards²

1970

Journal of Endocrinology

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SUMMARY Incubation of the adrenocortical tissue of Xenopus with labelled steroidal precursors gave aldosterone, corticosterone, 11-deoxycorticosterone and 18-hydroxycorticosterone as the major products. Kinetic studies indicated that the major biosynthetic pathway in Xenopus is the same as that in the duck, cobra and frog, and follows the sequence: pregnenolone → progesterone → 11-deoxycorticosterone → corticosterone → aldosterone + 18-hydroxycorticosterone. The effects of adenohypophysectomy and of injection of mammalian corticotrophin (ACTH) on the corticosteroidogenetic capacity of Xenopus were also studied. The production of both aldosterone and corticosterone increased after ACTH administration and decreased markedly after adenohypophysectomy. Some of the evidence suggests that ACTH was effective at biosynthetic stages following the formation of pregnenolone. The present studies on corticosteroid production were done in conjunction with parallel investigations on osmoregulation and electrolyte and water changes in Xenopus (Edwards, 1969).

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Renin–Angiotensin–Aldosterone System and the Renal Regulation of Sodium, Potassium, and Blood Pressure Homeostasis

Laragh

Sealey

1992

Comprehensive Physiology

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The sections in this article are: Historical Background Renin Aldosterone A Coordinated Renal‐Adrenal Hormonal System: Renin, Angiotensin, and Aldosterone Comparative Aspects Brief Overview of the Renin‐Angiotensin‐Aldosterone System Biochemistry and Molecular Biology of the Renin System Prorenin Renin Renin Substrate Angiotensins I and II Angiotensin‐Converting Enzyme Aldosterone Methods of Measurement Physiology Prorenin Renin Renin Substrate Angiotensin II Aldosterone Cybernetics of the System Coordinated Regulation of Sodium, Potassium, and Blood Pressure Use of the Renin System to Understand Blood Pressure Control and Disorders of Pressure‐Volume Homeostasis Two Forms of Vasoconstriction: Vasoconstriction‐Volume Analysis Three Basic Tenets Concerning Plasma Renin Measurements The Sodium—Calcium Connection Dynamic Reciprocity of Two Forms of Vasoconstriction The Sympathetic Nervous System and Modulation of the Two Forms of Arteriolar Vasoconstriction Human Disorders of the Renin System Hypertensive Disorders Renin System Abnormalities in Edematous States Hypokalemic Normotensive States Summary

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Effects of renin and ACTH on adrenal steroid secretion in the American bullfrog

Cited by 85 publications

References 0 publications

Metabolism and rate of secretion of aldosterone in the bullfrog

Metabolism and rate of secretion of aldosterone in the bullfrog

Kinetic Studies on the Biosynthesis of Corticosteroids in Vitro From Exogenous Precursors by the Interrenal Glands of the Normal, Corticotrophin-Treated and Adenohypophysectomized Xenopus Laevis Daudin

Renin–Angiotensin–Aldosterone System and the Renal Regulation of Sodium, Potassium, and Blood Pressure Homeostasis

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