Effects of renovascular hypertension on reproductive function in male rats

Breigeiron, Márcia Koja; Lucion, Aldo Bolten; Sanvitto, Gilberto Luiz

doi:10.1016/j.lfs.2007.01.030

Cited by 18 publications

(15 citation statements)

References 47 publications

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“…15 Even less attention has been given to sexual dysfunction that may affect subjects with renovascular hypertension. Confirming studies in male rats, 11,12 the data presented here indicate that renovascular hypertension promotes an overall reduction in female reproductive function in rats. Specifically, 2K1C female rats show decreased oocyte numbers, sexual behavior, and LH levels during the proestrus afternoon when compared with control sham rats.…”

Section: Discussionsupporting

confidence: 82%

“…In the animal literature, only a few studies using the well-established rodent model of renovascular hypertension-the 2-kidney, 1-clip (2K1C) Goldblatt model 9,10 -have analyzed reproductive function in male rats, reporting a drastic impairment in reproductive functions. 11,12 Clinical data support the suggestion that sexual dysfunction is more frequent in women than in men. 13,14 Despite this higher prevalence, clinical and preclinical studies on female sexual dysfunction are remarkably scarce, and the mechanisms by which hypertension interferes with female reproductive function are still not fully understood.…”

Section: Doi:101093/ajh/hps026mentioning

confidence: 64%

“…A silver clip (0.15-mm internal diameter) was placed around the left renal artery though a flank incision. 11,12 The same surgical procedure was used for sham-operated rats, except for the placement of the renal artery clip.…”

Section: K1c Surgerymentioning

confidence: 99%

“…Moreover, our results also corroborate other animal studies in which renovascular hypertensive male rats have shown sexual dysfunction. 11,12,28 The estradiol surge in proestrus is a required step to induce lordotic behavior. 29 However, 2K1C rats did not show any changes in estradiol levels in the proestrus afternoon, suggesting that the decreased sexual receptivity presented here is supported by other mechanisms.…”

Section: Hypertension and Sexual Behaviormentioning

confidence: 99%

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Reproductive Dysfunction in Female Rats With Renovascular Hypertension

Ribeiro

Raineki

Gonçalves

et al. 2012

American Journal of Hypertension

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Section: Discussionsupporting

confidence: 82%

Section: Doi:101093/ajh/hps026mentioning

confidence: 64%

Section: K1c Surgerymentioning

confidence: 99%

Section: Hypertension and Sexual Behaviormentioning

confidence: 99%

See 2 more Smart Citations

Reproductive Dysfunction in Female Rats With Renovascular Hypertension

Ribeiro

Raineki

Gonçalves

et al. 2012

American Journal of Hypertension

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show abstract

“…However, there are also reports of perturbations that are solely associated with certain conditions such as decreases in LH and FSH that have been found in models of hypertension (Breigeiron et al 2007), dyslipidemia (Yamamoto et al 1999) and obese humans (Sharpe 2010). Interestingly, our animal model of overall MetS displays all these facets (Filippi et al 2009).…”

Section: Discussionmentioning

confidence: 61%

Spermatogenic and sperm quality differences in an experimental model of metabolic syndrome and hypogonadal hypogonadism

Mallidis¹,

Czerwiec²,

Filippi³

et al. 2011

Reproduction

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The synergistic effect of the co-morbidities that comprise metabolic syndrome (MetS) is increasingly being recognised as an important contributor in the pathology of a broad spectrum of seemingly disparate conditions. However, in terms of male reproductive function, beyond erectile dysfunction, little is known about the influence of this cohort (collectively or separately) on spermatogenesis and sperm quality. The aims of this study were to assess the reproductive tract of a MetS animal model for detrimental changes, to determine whether a group of compounds (advanced glycation end products and their receptor) known to cause cell dysfunction and DNA damage was present and assess whether hypogonadotropic hypogonadism was the main contributing factor for the changes seen. Animals fed a high-fat diet were found to have significantly increased cholesterol, triglycerides, blood glucose, mean arterial pressure and visceral fat levels. Although serum testosterone was decreased, no changes were seen in either testicular or epididymal histology. Immunolocalisation of N 3 -carboxymethyl-lysine and the receptor for advanced glycation end products was found in the testes, epididymides and sperm of the two treated groups of animals; however, ELISA did not show any difference in protein levels. Similarly, assessment of sperm nuclear DNA (nDNA) fragmentation by acridine orange test did not find significant differences in nDNA integrity. We conclude that the minimal effect on spermatogenesis and sperm quality seen in our model is probably due to the moderate increase of blood glucose rather than the hypogonadism.

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Effects of litter‐overlapping on emotionality, stress response, and reproductive functions in male and female rats

Uriarte

Ferreira

Rosa

et al. 2008

Developmental Psychobiology

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In rats, mating at postpartum estrus and delayed dispersal of the young would result in the overlapping of two different-age litters. As a consequence, newborn pups' early experience will include not only that acquired during the interaction with the mother and age-matched littermates, but also with older siblings. As early-life experience modulates rodents' brain function, behavior and reproduction, we aimed to assess how changes in the early environment provoked by the overlapping of litters would affect emotionality, stress response and reproductive functions of male and female pups during adulthood. Results showed that both male and female overlapped reared pups exhibited a reduced behavioral inhibition in the open field test during adulthood. In addition, overlapped reared adult females, but not males, showed a blunted corticosterone response to an acute stressor during diestrus and a reduction in sexual behavior. In summary, natural changes in early experience provoked by the overlapping of litters, long-term modulate affective and reproductive behaviors, and the endocrine stress response in a sex dimorphic manner.

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Effects of renovascular hypertension on reproductive function in male rats

Cited by 18 publications

References 47 publications

Reproductive Dysfunction in Female Rats With Renovascular Hypertension

Reproductive Dysfunction in Female Rats With Renovascular Hypertension

Spermatogenic and sperm quality differences in an experimental model of metabolic syndrome and hypogonadal hypogonadism

Effects of litter‐overlapping on emotionality, stress response, and reproductive functions in male and female rats

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