Effects of repeated administration of methamphetamine on P3-like potentials in rats

Takeuchi, Satoshi; Jodo, Eiichi; Suzuki, Yoshiaki; Matsuki, Tomohiko; Niwa, Shin‐Ichi; Kayama, Yukihiko

doi:10.1016/s0167-8760(99)00016-1

Cited by 8 publications

(7 citation statements)

References 51 publications

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“…This idea is consistent with reports that a rat analog of P300 was reduced by 15 days of MA followed by over a week of abstinence, 44 just as the human P300 is reduced during recovery from MA-abuse. 45 Limitations This study has a small sample size of abstaining MA users.…”

Section: Importance Of Absolute Measuressupporting

confidence: 91%

Changes in cerebral glucose metabolism during early abstinence from chronic methamphetamine abuse

et al. 2007

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Changes in brain function during the initial weeks of abstinence from chronic methamphetamine abuse may substantially affect clinical outcome, but are not well understood. We used positron emission tomography with [F-18]fluorodeoxyglucose (FDG) to quantify regional cerebral glucose metabolism, an index of brain function, during performance of a vigilance task. A total of 10 methamphetamine-dependent subjects were tested after 5-9 days of abstinence, and after 4 additional weeks of supervised abstinence. A total of 12 healthy control subjects were tested at corresponding times. Global glucose metabolism increased between tests (P = 0.01), more in methamphetamine-dependent (10.9%, P = 0.02) than control subjects (1.9%, NS). Glucose metabolism did not change in subcortical regions of methamphetaminedependent subjects, but increased in neocortex, with maximal increase ( > 20%) in parietal regions. Changes in reaction time and self-reports of negative affect varied more in methamphetamine-dependent than in control subjects, and correlated both with the increase in parietal glucose metabolism, and decrease in relative activity (after scaling to the global mean) in some regions. A robust relationship between change in self-reports of depressive symptoms and relative activity in the ventral striatum may have great relevance to treatment success because of the role of this region in drug abuse-related behaviors. Shifts in corticalsubcortical metabolic balance either reflect new processes that occur during early abstinence, or the unmasking of effects of chronic methamphetamine abuse that are obscured by suppression of cortical glucose metabolism that continues for at least 5-9 days after cessation of methamphetamine self-administration.

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Section: Importance Of Absolute Measuressupporting

confidence: 91%

Changes in cerebral glucose metabolism during early abstinence from chronic methamphetamine abuse

et al. 2007

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“…In monkeys, scopolamine prolonged the latency of the late P300-like potentials in the cortex and hippocampus, whereas the novel benzodiazepine inverse agonist S-8510 reversed the scopolamine-induced deficit [133]. Rats performing an active discriminant task displayed larger amplitudes in target trials compared to nontarget trials [134,135,136], and repeated methamphetamine administration in this model reduced the amplitude of P3-like AEP, indicating that changes in catecholamine transmission may affect the P3 generation [136], whereas modafinil, a drug used for improving alertness, lowered behavioral performance, decreased P3-like latency, and slightly affected its amplitude [134]. …”

Section: Pharmaco-event-related Potentialsmentioning

confidence: 99%

Pharmaco-EEG Studies in Animals: An Overview of Contemporary Translational Applications

Drinkenburg

Ruigt²,

Ahnaou

2015

Neuropsychobiology

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The contemporary value of animal pharmaco-electroencephalography (p-EEG)-based applications are strongly interlinked with progress in recording and neuroscience analysis methodology. While p-EEG in humans and animals has been shown to be closely related in terms of underlying neuronal substrates, both translational and back-translational approaches are being used to address extrapolation issues and optimize the translational validity of preclinical animal p-EEG paradigms and data. Present applications build further on animal p-EEG and pharmaco-sleep EEG findings, but also on stimulation protocols, more specifically pharmaco-event-related potentials. Pharmaceutical research into novel treatments for neurological and psychiatric diseases has employed an increasing number of pharmacological as well as transgenic models to assess the potential therapeutic involvement of different neurochemical systems and novel drug targets as well as underlying neuronal connectivity and synaptic function. Consequently, p-EEG studies, now also readily applied in modeled animals, continue to have an important role in drug discovery and development, with progressively more emphasis on its potential as a central readout for target engagement and as a (translational) functional marker of neuronal circuit processes underlying normal and pathological brain functioning. In a similar vein as was done for human p-EEG studies, the contribution of animal p-EEG studies can further benefit by adherence to guidelines for methodological standardization, which are presently under construction by the International Pharmaco-EEG Society (IPEG).

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“…107 Hence, they concluded that the locus coeruleus noradrenergic system makes a modality-specic contribution towards the generation of the P3-like potential. More recently, Takeuchi, et al 144 reported that the repeated administration of methamphetamine (MAP) caused a reduction in the amplitude (but no latency change) of the auditory P3-like potential in rats. They concluded that the change in catecholaminergic transmission induced by the repeated administration of MAP affects the mechanism eliciting the P300.…”

Section: Animal Modelsmentioning

confidence: 99%

Neural Origins of the P300

2000

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A review of the literature investigating the neural origins of detection behavior in humans reveals two event-related potential components, P3a and P3b, each with a distinct neural organization and cognitive function. The P3a is involved in automatic novelty detection and characterized by a more anterior cortical distribution, whereas the P3b is concerned with volitional target detection and has a more posterior cortical distribution. Intracranial investigation, studies with patients with focal brain lesions, and functional neuroimaging (fMRI) studies converge with the scalp-recorded ERP data in suggesting that a widespread cortical network gives rise to both automatic and controlled detection behavior. The main regions consistently attributed to generating detection related brain activation include the temporal-parietal junction, medial temporal complex, and the lateral prefrontal cortex. The extant human and animal literature addressing the neural networks, neuropharmacological underpinnings, and behavioral signicance of "the P300" potential will be reviewed.

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Effects of repeated administration of methamphetamine on P3-like potentials in rats

Cited by 8 publications

References 51 publications

Changes in cerebral glucose metabolism during early abstinence from chronic methamphetamine abuse

Changes in cerebral glucose metabolism during early abstinence from chronic methamphetamine abuse

Pharmaco-EEG Studies in Animals: An Overview of Contemporary Translational Applications

Neural Origins of the P300

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