Effects of Repeated Administrations of Tafluprost, Latanoprost, and Travoprost on Optic Nerve Head Blood Flow in Conscious Normal Rabbits

Akaishi, Takahiro; Kurashima, Hiroaki; Odani-Kawabata, Noriko; Ishida, Narihiro; Nakamura, Masatsugu

doi:10.1089/jop.2009.0100

Cited by 31 publications

(31 citation statements)

References 25 publications

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“…who found that ONH blood flow increased in rabbit eyes after 28 days of treatment with any of the three F 2α prostaglandin analogs (tafluprost, latanoprost, or travoprost). 24 Using laser speckle flowgraphy, the effect of tafluprost (+11.9%) on blood flow was significantly greater than that seen with travoprost (+6.7%, P=0.037) and tended to be greater than that seen with latanoprost (+7.2%, P=0.086) at 60 min on day 28 post treatment. 24 Dong et al found that tafluprost induced concentration-dependent relaxation of precontracted isolated rabbit ciliary arteries, but by a mechanism that was independent of endothelial-derived factor.…”

Section: Tafluprost Efficacy and Safety -Preclinical And Animal Studiesmentioning

confidence: 86%

“…24 Using laser speckle flowgraphy, the effect of tafluprost (+11.9%) on blood flow was significantly greater than that seen with travoprost (+6.7%, P=0.037) and tended to be greater than that seen with latanoprost (+7.2%, P=0.086) at 60 min on day 28 post treatment. 24 Dong et al found that tafluprost induced concentration-dependent relaxation of precontracted isolated rabbit ciliary arteries, but by a mechanism that was independent of endothelial-derived factor. 25 28 In a more recent study, commercially available preservative-free tafluprost was applied directly onto the surface of a rat retinal explant culture.…”

Section: Tafluprost Efficacy and Safety -Preclinical And Animal Studiesmentioning

confidence: 86%

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Tafluprost: a novel prostaglandin analog for treatment of glaucoma

et al. 2011

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Section: Tafluprost Efficacy and Safety -Preclinical And Animal Studiesmentioning

confidence: 86%

Section: Tafluprost Efficacy and Safety -Preclinical And Animal Studiesmentioning

confidence: 86%

Tafluprost: a novel prostaglandin analog for treatment of glaucoma

et al. 2011

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“…87 Prostaglandin analogues have been found to increase ONH and retinal blood flow in humans as well as in experimental animals. [88][89][90][91] In a study in healthy volunteers, 2-week administration of topical latanoprost also improved choroidal blood flow regulation during both, an experimental increase and decrease in OPP compared with placebo, but this effect is most likely related to the ocular hypotensive effect of the drug. 92 Until recently, no clinical outcome data were available for any of the prostaglandin analogues, because most of the large-scale clinical outcome trials were started before this class of antiglaucoma drugs became commercially available.…”

Section: Topical Therapiesmentioning

confidence: 99%

Pharmacotherapy of Glaucoma

Schmidl

Schmetterer²,

Garhöfer³

et al. 2015

Journal of Ocular Pharmacology and Therapeutics

137

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Glaucoma is a group of diseases involving the optic nerve and associated structures, which is characterized by progressive visual field loss and typical changes of the optic nerve head (ONH). The only known treatment of the disease is reduction of intraocular pressure (IOP), which has been shown to reduce glaucoma progression in a variety of large-scale clinical trials. Nowadays, a relatively wide array of topical antiglaucoma drugs is available, including prostaglandin analogues, carbonic anhydrase inhibitors, beta-receptor antagonists, adrenergic agonists, and parasympathomimetics. In clinical routine, this allows for individualized treatment taking risk factors, efficacy, and safety into account. A major challenge is related to adherence to therapy. Sustained release devices may help minimize this problem but are not yet available for clinical routine use. Another hope arises from non-IOP-related treatment concepts. In recent years, much knowledge has been gained regarding the molecular mechanisms that underlie the disease process in glaucoma. This also strengthens the hope that glaucoma therapy beyond IOP lowering will become available. Implementing this concept with clinical trials remains, however, a challenge.

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“…Depending on the drug or formulation used, PGAs have been reported to increase, decrease, or not affect ocular blood flow. However, the reports are conflicting, with opposing results in some cases (19,20) . In the work presented here, both tafluprost BAK-free and travoprost BAK significantly reduced the RI of the OA in rabbits.…”

Section: Discussionmentioning

confidence: 99%

“…No effects on CDI parameters were found for topical bimatoprost BAK, travoprost POLYQUAD, or latanoprost BAK. Some research has also revealed no changes in the blood flow in the OA in humans and rabbits in response to PGAs, although some PGAs show good results in other vascular beds, such as on the optic nerve head and in the central retinal artery (20,(22)(23)(24) . Nevertheless, our research showed that the results with travoprost are controversial.…”

mentioning

confidence: 99%

Effects of prostaglandin analogs on blood flow velocity and resistance in the ophthalmic artery of rabbits

Giannico¹,

Lima²,

Shaw³

et al. 2016

Arquivos Brasileiros De Oftalmologia

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Approved by the following research ethics committee: Universidade Federal do Paraná, protocol #011/2011. ABSTRACTPurpose: The aim of this study was to investigate the effects of prostaglandin analogs on blood flow in the ophthalmic artery of clinically healthy rabbits. Methods: Fifty-five clinically healthy New Zealand white rabbits were divided into six groups, and the left eyes were treated for four weeks with the preservative benzalkonium chloride (BAK) only or a topical formulation of different prostaglandin analogs (bimatoprost BAK, tafluprost BAK-free, travoprost BAK, travoprost POLYQUAD, and latanoprost BAK). Color Doppler imaging was performed before and after the treatments. The mean values of the peak systolic velocity (PSV) and end diastolic velocity and the resistive index (RI) were calculated. Statistical analysis was performed to compare the differences pre-and post-treatment for each drug and post-treatment among the drugs. Results: The prostaglandin analogs did not affect PSV. Bimatoprost BAK, travoprost POLYQUAD, and latanoprost BAK did not change RI. Tafluprost BAK-free and travoprost BAK therapy resulted in similar reductions in RI. No significant differences pre-and post-treatment were found when BAK was administered alone. Conclusion:The prostaglandin analogs tafluprost BAK-free and travoprost BAK improved blood flow in the ophthalmic artery in healthy New Zealand white rabbits, which suggests that these drugs enhance the prevention of the progression the progression of glaucoma. Keywords

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Effects of Repeated Administrations of Tafluprost, Latanoprost, and Travoprost on Optic Nerve Head Blood Flow in Conscious Normal Rabbits

Cited by 31 publications

References 25 publications

Tafluprost: a novel prostaglandin analog for treatment of glaucoma

Tafluprost: a novel prostaglandin analog for treatment of glaucoma

Pharmacotherapy of Glaucoma

Effects of prostaglandin analogs on blood flow velocity and resistance in the ophthalmic artery of rabbits

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