Effects of repeated as compared to single aggressive confrontation on nociception and defense behavior in C57BL/6 and DBA/2 mice

Külling, P.; Frischknecht, Hans-Rudolf; Pasi, Aurelio; Waser, Peter G.; Siegfried, Bert

doi:10.1016/0031-9384(87)90159-4

Cited by 25 publications

(7 citation statements)

References 32 publications

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“…No evidence for conditioned analgesia was found insofar as the comparison between baseline and postconfrontation values on Day 2 did not yield a significant difference (baseline: M = 1.86, interquartile range = 1.18−2.15; after confrontation: M = 1.97, interquartile range = 1.43−2.32). Absence of a conditioned social-conflict-induced analgesia has also been shown in the hot-plate assay (Külling, Frischknecht, Pasi, Waser, & Siegfried, 1987) and supports results of other researchers who failed to find a conditioned response after stress-induced analgesia (e.g., Kameyama, Nabeshima, & Yamada, 1985; Ross & Randich, 1984). On the other hand, these studies are in contrast to a number of reports that showed that originally neutral stimuli acquired the capacity to inhibit pain when paired with aversive analgesia-inducing stimuli (Chance et al, 1977; Fanselow & Bolles, 1979; MacLennan et al, 1980; Oliverio & Castellano, 1982).…”

Section: Resultssupporting

confidence: 87%

Long-term analgesic reaction in attacked mice.

Siegfried¹,

Frischknecht²,

Riggio³

et al. 1987

Behavioral Neuroscience

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Four experiments were designed to characterize long-term analgesic (LTA) reaction in attacked mice. In Experiment 1 we showed that analgesic reaction in DBA mice, induced by the stress of being attacked (30 or 50 bites), is reinstated upon reexposure to seven bites 24 hr later. The magnitude of the LTA response depended on the level of analgesia on Day 1 and was smaller than the original response. In Experiment 2 we showed that LTA was prevented by naloxone or beta-chlornaltrexamine given before exposure (50 bites) on Day 1. Results of Experiment 3 revealed that naloxone or beta-chlornaltrexamine injected before reexposure to seven bites on Day 2 antagonized LTA measured 10 min, but not 1 min, after reexposure. In Experiment 4 we showed that morphine substituted for being attacked on Day 1 failed to produce LTA. We concluded that pain inhibitory mechanisms remain in a state of increased readiness for at least 24 hr after attack stress and that activation of opioid systems is necessary but not sufficient to produce LTA, a response that is only partly sensitive to opioid antagonists.

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Section: Resultssupporting

confidence: 87%

Long-term analgesic reaction in attacked mice.

Siegfried¹,

Frischknecht²,

Riggio³

et al. 1987

Behavioral Neuroscience

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“…In addition, for specific behaviors, some strains are more useful than others. For example, in mice, DBA/2 is an aggressive strain while C57BL/6 is not [116]. If expression of a gene is hypothesized to reduce resident-intruder aggression, it might be best to knock it down in a relatively unaggressive strain, such as C57BL/6.…”

Section: Introductionmentioning

confidence: 99%

Of mice and rats: Key species variations in the sexual differentiation of brain and behavior

Bonthuis

Cox

Searcy

et al. 2010

Frontiers in Neuroendocrinology

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Mice and rats are important mammalian models in biomedical research. In contrast to other biomedical fields, work on sexual differentiation of brain and behavior has traditionally utilized comparative animal models. As mice are gaining in popularity, it is essential to acknowledge the differences between these two rodents. Here we review neural and behavioral sexual dimorphisms in rats and mice, which highlight species differences and experimental gaps in the literature, that are needed for direct species comparisons. Moving forward, investigators must answer fundamental questions about their chosen organism, and attend to both species and strain differences as they select the optimal animal models for their research questions.

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“…The attack parameters and the time course for defeat-induced swim suppression observed in the present study were therefore very similar to those of defeat analgesia in DBA/2 mice. It is interesting that strains of mice that show defeat analgesia have very different responses to attack than strains in which defeat analgesia is not observed [Kulling et al, 1987]. Compared with C57s, a strain that does not show defeat analgesia, DBAs display higher probabilities of escape responses (as opposed to upright defenses) on initial attack by a conspecific [Kulling et al, 1987].…”

Section: Discussionmentioning

confidence: 99%

“…It is interesting that strains of mice that show defeat analgesia have very different responses to attack than strains in which defeat analgesia is not observed [Kulling et al, 1987]. Compared with C57s, a strain that does not show defeat analgesia, DBAs display higher probabilities of escape responses (as opposed to upright defenses) on initial attack by a conspecific [Kulling et al, 1987]. However, as attacks persist, mice of the DBA/2 strain display strong behavioral passivity that is paralleled by the development of opioid analgesia [Frischknecht and Siegfried, 1988;Rodgers, 1995].…”

Section: Discussionmentioning

confidence: 99%