Effects of repeated drug administration on behaviors in normal mice and fluoxetine efficacy in chronic unpredictable mild stress mice

Li, Qinxi; Zhao, Bangcheng; Li, Wanxin; Yuan, He; Tang, Xun; Zhang, Ting; Zhong, Zhihui; Pan, Qiangwen; Zhang, Yingqian

doi:10.1016/j.bbrc.2022.05.041

Cited by 7 publications

(8 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The study confirmed the sensitivity of EPM and LDB in detecting anxiolytic compounds, proving their reliability (34). Previous research has shown that OFT is less reliable due to the administration operation's interference with the actual experimental results, primarily when orally administered to mice fed different diets (35). In contrast, rearing times were the most sensitive index on OFT as it reveals a mouse's exercise capacity in vertical directions (36).…”

Section: Discussionsupporting

confidence: 69%

“…Besides, administrating buspirone by intraperitoneal (IP) injection rather than intragastric (IG) administration might cause a slight difference in anxiety levels. Previously, we proved that IP exhibited superior therapeutic efficacy, which is more suitable for administering positive control (35). However, it did not affect the evaluation of combinations in this study.…”

Section: Discussionmentioning

confidence: 66%

See 1 more Smart Citation

Combination of Walnut Peptide and Casein Peptide alleviates anxiety and improves memory in anxiety mices

Li,

Jia,

Zhong

et al. 2023

Front. Nutr.

Self Cite

View full text Add to dashboard Cite

IntroductionAnxiety disorders continue to prevail as the most prevalent cluster of mental disorders following the COVID-19 pandemic, exhibiting substantial detrimental effects on individuals’ overall well-being and functioning. Even after a search spanning over a decade for novel anxiolytic compounds, none have been approved, resulting in the current anxiolytic medications being effective only for a specific subset of patients. Consequently, researchers are investigating everyday nutrients as potential alternatives to conventional medicines. Our prior study analyzed the antianxiety and memory-enhancing properties of the combination of Walnut Peptide (WP) and Casein Peptide (CP) in zebrafish.Methods and ResultsBased on this work, our current research further validates their effects in mice models exhibiting elevated anxiety levels through a combination of gavage oral administration. Our results demonstrated that at 170 + 300 mg human dose, the WP + CP combination significantly improved performances in relevant behavioral assessments related to anxiety and memory. Furthermore, our analysis revealed that the combination restores neurotransmitter dysfunction observed while monitoring Serotonin, gamma-aminobutyric acid (GABA), dopamine (DA), and acetylcholine (ACh) levels. This supplementation also elevated the expression of brain-derived neurotrophic factor mRNA, indicating protective effects against the neurological stresses of anxiety. Additionally, there were strong correlations among behavioral indicators, BDNF (brain-derived neurotrophic factor), and numerous neurotransmitters.ConclusionHence, our findings propose that the WP + CP combination holds promise as a treatment for anxiety disorder. Besides, supplementary applications are feasible when produced as powdered dietary supplements or added to common foods like powder, yogurt, or milk.

show abstract

Section: Discussionsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 66%

Combination of Walnut Peptide and Casein Peptide alleviates anxiety and improves memory in anxiety mices

Li,

Jia,

Zhong

et al. 2023

Front. Nutr.

Self Cite

View full text Add to dashboard Cite

show abstract

“…We did not administrate IC through gavage; thus, we cannot know the exact amount each rat drank. Although, on some occasions, gavage can be used, it has been demonstrated that the repeated use of this technique can have important effects on body weight gain and behavioral assays [ 77 , 78 , 79 ]. On the other hand, the animals were not isolated in metabolic cages (which would have provided more accurate solid and liquid intake data) to avoid alterations associated with isolation-induced stress.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Effects of Instant Cascara Beverage on the Brain-Gut Axis of Healthy Male and Female Rats

Gallego-Barceló,

Bagues,

Benítez-Álvarez

et al. 2023

Nutrients

View full text Add to dashboard Cite

Instant cascara (IC) is a sustainable beverage obtained from dried coffee cherry pulp, rich in nutrients and bioactive compounds. The present research aimed to determine the effects of IC on general health and brain-gut axis parameters of healthy female and male rats. Wistar rats were exposed to IC (10 mg/mL) in their drinking water for 3 weeks. Body weight and solid and liquid intakes were monitored as indicators of food safety. Gastrointestinal transit was radiographically evaluated one day (acute) and 3 weeks (chronic) after the start of IC exposure. Locomotor activity, anxiety, and anhedonia of the animals after 3 weeks of treatment was also studied. Overall, compared to water-exposed animals, IC significantly increased food intake in males (p < 0.0001) and liquid intake in females (p < 0.05) without changes in body weight in either case. IC did not significantly modify gastrointestinal motility parameters after its acute or repeated intake and did not cause any significant behavioral alterations in males or females (p > 0.05). In conclusion, repeated intake of IC at the studied concentration did not negatively affect brain-gut axis functions of healthy male and female rats. Anxiety behavior, diarrhea, constipation, abnormal weight modifications, or other typical effects of toxicity were not observed in animals treated with the new powdered beverage, suggesting its food safety under the studied conditions.

show abstract

“…Por su parte, no encontramos diferencias en ninguna de las variables analizadas en los ratones PCD debidas al efecto de las inyecciones continuas. Por ello, podemos descartar la influencia del estrés en todos estos resultados, tal y como se ha descrito en otras ocasiones (Du Preez et al, 2020;Li et al, 2022;Ryabinin et al, 1999).…”

Section: El Rhigf-1 No Produce Un Efecto Neuroprotector En Los Ratone...unclassified

“…Por otro lado, no encontramos diferencias en el peso entre los ratones PCD estándar, los tratados con NaCl y los tratados con rhVEGF-B -ya sea continuo o cada dos días-. Así, pudimos constatar que el tratamiento con rhVEGF-B no produce efectos sobre el peso corporal y que la administración continua tampoco ocasiona cambios en estos animales, tal y como se ha reportado en otras ocasiones (Ryabinin et al, 1999;Du Preez et al, 2020;Li et al, 2022). La ausencia de efectos a este nivel es fácilmente explicable, ya que, a diferencia de otros factores neurotróficos como el IGF-1 (Laron, 2001;Yakar y Adamo, 2012), el VEGF-B no ejerce un efecto directo sobre el crecimiento de los tejidos, sino que este se relaciona con la neuroprotección (Sun et al, 2006;Poesen et al, 2008;Falk et al, 2009;Yue et al, 2014) y la regulación de la calidad mitocondrial (Olsson et al, 2006;Falk et al, 2010;Yue et al, 2014), tal y como veremos más adelante.…”

Section: El Rhvegf-b Ejerce Un Efecto Neuroprotector En El Ratón Pcdunclassified

Factores neurotróficos y su efecto neuroprotector en un modelo murino de degeneración neuronal selectiva

Pérez Revuelta

View full text Add to dashboard Cite

Effects of repeated drug administration on behaviors in normal mice and fluoxetine efficacy in chronic unpredictable mild stress mice

Cited by 7 publications

References 25 publications

Combination of Walnut Peptide and Casein Peptide alleviates anxiety and improves memory in anxiety mices

Combination of Walnut Peptide and Casein Peptide alleviates anxiety and improves memory in anxiety mices

Evaluation of the Effects of Instant Cascara Beverage on the Brain-Gut Axis of Healthy Male and Female Rats

Factores neurotróficos y su efecto neuroprotector en un modelo murino de degeneración neuronal selectiva

Contact Info

Product

Resources

About