Effects of Repeated Electroconvulsive Seizures on Spontaneous Alternation Behavior and Locomotor Activity in Rats

Hidaka, Noriaki; Suemaru, Katsuya; Li, Bingjin; Araki, Hiroaki

doi:10.1248/bpb.31.1928

Cited by 25 publications

(6 citation statements)

References 39 publications

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“…Related to this, previous studies have been demonstrated that repeated ECS treatment reduced immobility time in the FST (Porsolt et al 1977;Li et al 2006), and 1 group also showed that repeated ECS treatment increased locomotor activity in the open field test (Hidaka et al 2008). These results suggest that ECS treatment increases energy expenditure under stressful conditions.…”

Section: Effect Of Repeated Ecs On Body Weight and Antidepressant-likmentioning

confidence: 53%

Electroconvulsive seizures activate anorexigenic signals in the ventromedial nuclei of the hypothalamus

et al. 2013

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The ventromedial nucleus of the hypothalamus (VMH) plays an important role in feeding and energy homeostasis. Electroconvulsive seizure (ECS) therapy is highly effective in the treatment of several psychiatric diseases, including depression, but may also have beneficial effects in other neurological diseases. Although it has been reported that the neurons of the VMH are strongly activated by ECS stimulation, the specific effects of ECS in this hypothalamic subnucleus remain unknown. To address this issue, we investigated the changes in gene expression in microdissected-VMH samples in response to ECS in mice, and examined the behavioral effects of ECS on feeding behavior. ECS significantly induced the expression of immediate-early genes such as Fos, Fosb, and Jun, as well as Bdnf, Adcyap1, Hrh1, and Crhr2 in the VMH. Given that signals of these gene products are suggested to have anorexigenic roles in the VMH, we also examined the effect of ECS on food intake and body weight. Repeated ECS had a suppressive effect on food intake and body weight gain under both regular and high-fat diet conditions. Furthermore, gold-thioglucose-induced hypothalamic lesions, including the VMH and the arcuate nucleus, abolished the anorexigenic effects of ECS, indicating the requirement for the activation of the hypothalamus. Our data show an effect of ECS on increased expression of anorexigenic factors in the VMH, and suggest a role in the regulation of energy homeostasis by ECS.

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Section: Effect Of Repeated Ecs On Body Weight and Antidepressant-likmentioning

confidence: 53%

Electroconvulsive seizures activate anorexigenic signals in the ventromedial nuclei of the hypothalamus

et al. 2013

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“…Repeated ECSs could cause spatial‐learning deficits in the Morris water maze task following a 2‐month recovery period in rats (Lukoyanov et al,2004). Another study (Hidaka et al,2008) showed that repeated ECSs significantly impaired spontaneous alternation and increased locomotor activity, and behavioral changes induced by repeated ECSs persisted for at least 28 days. These findings may be related to neurogensis or apoptosis.…”

Section: Discussionmentioning

confidence: 97%

Effects of repeated electroconvulsive seizure on cell proliferation in the rat hippocampus

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Seki

Liu

et al. 2010

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Electroconvulsive therapy (ECT) is known as a successful treatment for severe depression. Despite great efforts, the biological mechanisms underlying the beneficial effects of ECT remain largely unclear. In this study, animals received a single, 10, or 20 applications of electroconvulsive seizure (ECS), and then cell proliferation and apoptosis were investigated in the subgranular zone (SGZ) of the dentate gyrus. We analyzed whether a series of ECSs could induce changes in the dentate gyrus in a dose-response fashion. A single-ECS seizure significantly increased cell proliferation in the SGZ by ∼2.3-fold compared to sham treatment. After 10 ECSs, a significant increase in cell proliferation was observed in the SGZ by ∼2.4-fold compared to sham treatment. Moreover, 10 ECSs induced a significant increase in cell proliferation by 1.3-fold compared to a single-ECS group. However, cell proliferation did not differ between the group with 20 ECSs and sham group. In addition, a significant increase in the number of apoptotic cells was found in the group with 10 ECSs, whereas no significant change in it was found in either a single ECS or 20 ECSs group compared to sham treatment. These findings indicate that the optimal number of treatments and duration of stimulation requires investigation. Further studies are needed to elucidate the intracellular mechanisms underlying both effective and excessive ECT.

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“…The alternation score was calculated as the ratio between actual alternations and possible alternations (defined as the total number of arm visits minus 2), multiplied by 100. This calculation was only performed for rats making more than fifteen arm visits ( Hidaka et al, 2008 ).…”

Section: Methodsmentioning

confidence: 99%

Intracerebral Hemorrhage-Induced Cognitive Impairment in Rats Is Associated With Brain Atrophy, Hypometabolism, and Network Dysconnectivity

et al. 2022

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The mechanisms underlying intracerebral hemorrhage (ICH)-related cognitive impairment (CI) remain unclear. Long-term structural and functional changes were investigated in the brains of healthy male and female Wistar rats after experimental ICH. Following double injection of autologous blood, rats underwent short-term (onset, 3 and 7 days) and long-term (3 and 6 months) radiological assessment and behavioral tests exploring spontaneous locomotion, anxiety-like behavior and working memory, spatial recognition memory and visual recognition memory. Volumetric and metabolic changes in brain areas were examined by 7Tesla-MRI and [18F] FDG-PET, respectively. Brain connectomic disorders and maladaptive processes were seeked through brain metabolic connectivity analysis and atrophy-related network analysis. From an initial hematoma mean volume of 23.35 ± 9.50 mm3, we found early spontaneous locomotor recovery and significant spontaneous blood resorption (≈ 40% of the initial lesion) from days 0 to 7. After 3 and 6 months, ICH rats exhibited CI in several domains as compared to the sham group (working memory: 58.1 ± 1.2 vs. 70.7 ± 1.2%, p < 0.001; spatial recognition memory: 48.7 ± 1.9 vs. 64 ± 1.8%, p < 0.001 and visual recognition memory: 0.14 ± 0.05 vs. 0.33 ± 0.04, p = 0.013, in female only). Rats that experienced ICH had remote and concomitant cerebral atrophy and hypometabolism of ipsilateral striatum, thalamus, limbic system and cortical areas (temporal and parietal lobes). Interestingly, both structural and metabolic deterioration was found in the limbic system connected to the affected site, but remotely from the initial insult. On the other hand, increased activity and functional connectivity occurred in the contralateral hemisphere. These connectomics results showed that both maladaptative and compensation processes coexist in the rat brain following ICH, even at young age and in a disease-free setting. These radiological findings deepen our understanding of ICH-related CI and may serve as biomarkers in the view of future therapeutic intervention.

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Effects of Repeated Electroconvulsive Seizures on Spontaneous Alternation Behavior and Locomotor Activity in Rats

Abstract: Epileptic patients are at a significantly higher risk for impairments of cognitive function and behavioral abnormalities. In this study, we investigated the effect of repeated electroconvulsive shock (

Cited by 25 publications

References 39 publications

Electroconvulsive seizures activate anorexigenic signals in the ventromedial nuclei of the hypothalamus

Electroconvulsive seizures activate anorexigenic signals in the ventromedial nuclei of the hypothalamus

Effects of repeated electroconvulsive seizure on cell proliferation in the rat hippocampus

Intracerebral Hemorrhage-Induced Cognitive Impairment in Rats Is Associated With Brain Atrophy, Hypometabolism, and Network Dysconnectivity

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