Effects of Repeated Overdoses of Kothala-kimbutu Extract in Drinks

Ozaki, Sei; Tamura, Hirohide; Kataoka, Kensuke

doi:10.3136/nskkk.55.481

Cited by 1 publication

(1 citation statement)

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“…These edible plants have been confirmed to provide health maintenance effects in humans, such as suppressing blood glucose level elevation, decreasing body weight, and reducing LDL cholesterol levels [ 10 , 11 ]. With their safety having been established, these plants have attracted increasing attention in recent years as safe and useful foods [ 12 – 15 ].…”

Section: Introductionmentioning

confidence: 99%

Improvement in Human Immune Function with Changes in Intestinal Microbiota by Salacia reticulata Extract Ingestion: A Randomized Placebo-Controlled Trial

et al. 2015

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Plants belonging to the genus Salacia in the Hippocrateaceae family are known to inhibit sugar absorption. In a previous study, administration of Salacia reticulata extract in rats altered the intestinal microbiota and increased expression of immune-relevant genes in small intestinal epithelial cells. This study aimed to investigate the effect of S. reticulata extract in human subjects by examining the gene expression profiles of blood cells, immunological indices, and intestinal microbiota. The results revealed an improvement in T-cell proliferation activity and some other immunological indices. In addition, the intestinal microbiota changed, with an increase in Bifidobacterium and a decrease in Clostridium bacteria. The expression levels of many immune-relevant genes were altered in blood cells. We concluded that S. reticulata extract ingestion in humans improved immune functions and changed the intestinal microbiota. Trial Registration: UMIN Clinical Trials Registry UMIN000011732

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