2023
DOI: 10.1371/journal.pone.0287506
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Effects of repetitive mild traumatic brain injury on weight gain and chronic behavioral outcomes in male rats

Martha A. Graham,
Patria T. Juzang,
Todd E. White

Abstract: To assess the long-term behavioral effects of repetitive mild traumatic brain injury (rmTBI), we employed a preclinical model of rmTBI and performed a battery of behavioral tests starting 14 weeks post-injury. Male Sprague-Dawley rats received four unilateral mild (6 m/s; 0.5 mm depth) controlled cortical impacts (CCI), centered 4 mm posterior and 3–4 mm lateral to the bregma, administered at five-day intervals. The animals’ weights were monitored throughout the study. We tested the rats for anxiety-like (elev… Show more

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