Effects of Repetitive Transcranial Magnetic Stimulation on Auditory Hallucinations Refractory to Clozapine

Rosa, Marina Odebrecht; Rosa, Moacyr Alexandro; Rigonatti, Sergio P.; Cabral, Sergio B.; Myczkowski, Martin Luiz; Sartorelli, Maria C.; Tavares, Hildeberto; Rumi, Demétrio Ortega; Marcolin, Marco Antônio

doi:10.1097/00124509-200603000-00024

Cited by 23 publications

(35 citation statements)

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“…We carefully reviewed the last 17 studies and excluded the following: Saba et al (2006) We did not make successful contact to obtain the missing data from Rosa et al (2007), so this study was also excluded from the meta-analysis. Ten studies met criteria needs for our meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

A systematic review and meta-analysis of the use of repetitive transcranial magnetic stimulation for auditory hallucinations treatment in refractory schizophrenic patients

Otani

Shiozawa

Cordeiro

et al. 2014

International Journal of Psychiatry in Clinical Practice

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Section: Resultsmentioning

confidence: 99%

A systematic review and meta-analysis of the use of repetitive transcranial magnetic stimulation for auditory hallucinations treatment in refractory schizophrenic patients

Otani

Shiozawa

Cordeiro

et al. 2014

International Journal of Psychiatry in Clinical Practice

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“…For the analysis on the therapeutic use of rTMS on AH, exclusively, we extracted a subset of 9 studies, from the previously selected 12 reports, excluding 2 trials for not reporting a composite score for the AHRS (Lee et al, 2005; Rosa et al, 2007), and 1 concerning the treatment of delusions (Saba et al, 2006) (table 2). …”

Section: Resultsmentioning

confidence: 99%

Meta-analysis of the effects of repetitive transcranial magnetic stimulation (rTMS) on negative and positive symptoms in schizophrenia

Freitas

Fregni

Pascual‐Leone

2009

Schizophrenia Research

213

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Background-A growing body of evidence suggests that repetitive transcranial magnetic stimulation (rTMS) can alleviate negative and positive symptoms of refractory schizophrenia. However, trials to date have been small and results are mixed.Methods-We performed meta-analyses of all prospective studies of the therapeutic application of rTMS in refractory schizophrenia assessing the effects of high-frequency rTMS to the left dorsolateral prefrontal cortex (DLPFC) to treat negative symptoms, and low-frequency rTMS to the left temporo-parietal cortex (TPC) to treat auditory hallucinations (AH) and overall positive symptoms.Results-When analyzing controlled (active arms) and uncontrolled studies together, the effect sizes showed significant and moderate effects of rTMS on negative and positive symptoms (based on PANSS-N or SANS, and PANSS-P or SAPS, respectively). However, the analysis for the shamcontrolled studies revealed a small non-significant effect size for negative (0.27, p=0.417) and for positive symptoms (0.17, p=0.129). When specifically analyzing AH (based on AHRS, HCS or SAH), the effect size for the sham-controlled studies was large and significant (1.04; p=0.002).Conclusions-These meta-analyses support the need for further controlled, larger trials to assess the clinical efficacy of rTMS on negative and positive symptoms of schizophrenia, while suggesting the need for exploration for alternative stimulation protocols.

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“…In the 2 studies not included in the meta-analysis, one had insufficient data to calculate an effect size 124 and the other had not yet been published. 125 Rosa and colleagues treated 11 people with schizophrenia on clozapine with refractory auditory hallucinations over 10 days with low frequency rTMS or sham treatment. No significant difference was seen between treatments.…”

Section: Rtms For the Treatment Of Schizophreniamentioning

confidence: 99%

The 2009 Schizophrenia PORT Psychopharmacological Treatment Recommendations and Summary Statements

Boyer

Kreyenbuhl

Kelly

et al. 2009

Schizophrenia Bulletin

825

537

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Effects of Repetitive Transcranial Magnetic Stimulation on Auditory Hallucinations Refractory to Clozapine

Cited by 23 publications

References 0 publications

A systematic review and meta-analysis of the use of repetitive transcranial magnetic stimulation for auditory hallucinations treatment in refractory schizophrenic patients

A systematic review and meta-analysis of the use of repetitive transcranial magnetic stimulation for auditory hallucinations treatment in refractory schizophrenic patients

Meta-analysis of the effects of repetitive transcranial magnetic stimulation (rTMS) on negative and positive symptoms in schizophrenia

The 2009 Schizophrenia PORT Psychopharmacological Treatment Recommendations and Summary Statements

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