Effects of Replicative Senescence of Human Chorionic MSCs on their EV-miRNA Profile
Hedviga Košuthová,
Lívia K. Fecskeová,
Jana Matejová
et al.
Abstract:Chorionic mesenchymal stromal cells (CHO-MSCs) and their extracellular vesicles (EVs) are becoming increasingly popular, since chorion is ethically harmless and an easily accessible source of MSCs. However, until now there is only a limited number of studies with a thorough characterization of CHO-MSCs derived EVs and their miRNA profile. In this study, we monitored changes in the EV-miRNA profile between early and late passage of human CHO-MSCs. First, senescence of CHO-MSCs was induced by serial passaging an… Show more
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