Effects of Reserpine and Desipramine on the Uptake and Subcellular Distribution of 5-Hydroxytryptamine in Rabbit Brain Stem After Intravenous Administration of 5-Hydroxytryptophan

Segawa, Tomio

doi:10.1254/jjp.20.87

Japanese Journal of Pharmacology

1970

DOI: 10.1254/jjp.20.87

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Effects of Reserpine and Desipramine on the Uptake and Subcellular Distribution of 5-Hydroxytryptamine in Rabbit Brain Stem After Intravenous Administration of 5-Hydroxytryptophan

Tomio Segawa

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1971

1979

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Cited by 8 publications

References 8 publications

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Effects of amitriptyline and isocarboxazid on 5-hydroxytryptophan induced head twitches in mice

1976

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Effects of amitriptyline and isocarboxazid on brain 5-HT and 5-HIAA were examined in relation to their action on 5-HTP induced head twitches. Amitriptyline reduced 5-HTP induced head twitches but isocarboxazid increased them. Both amitriptyline and isocarboxazid caused a significant increase of brain 5-HT concentration in 5-HTP treated mice. Amitriptyline also caused a significant increase of 5-HIAA concentration, while isocarboxazid reduced 5-HIAA concentration in the brains of 5-HTP treated mice. Probenecid, which significantly increased 5-HIAA concentration without affecting brain 5-HT concentration in 5-HTP treated mice, reduced 5-HTP induced heat twitches. These results suggest that 5-HTP induced head twitches might be induced by an increase of 5-HT concentration, and reduced by an increase of 5-HIAA or a decrease of 5-HT concentration in the brains of mice.

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Effects of amitriptyline and isocarboxazid on 5-hydroxytryptophan induced head twitches in mice

1976

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Effect of serotonin on transcommissural evoked potentials of the baso-lateral portion of the amygdala

Teten'chukand¹,

Gilev²

1973

Bull Exp Biol Med

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Influences of intraventricularly administered 5-hydroxytryptamine on normal and amine-depleted rabbit: subcellular distribution of 5-hydroxytryptamine in the brain stem, and animal behaviour

Segawa¹,

Fujisawa²

1972

Biochemical Pharmacology

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Effects of Reserpine and Desipramine on the Uptake and Subcellular Distribution of 5-Hydroxytryptamine in Rabbit Brain Stem After Intravenous Administration of 5-Hydroxytryptophan

Cited by 8 publications

References 8 publications

Effects of amitriptyline and isocarboxazid on 5-hydroxytryptophan induced head twitches in mice

Effects of amitriptyline and isocarboxazid on 5-hydroxytryptophan induced head twitches in mice

Effect of serotonin on transcommissural evoked potentials of the baso-lateral portion of the amygdala

Influences of intraventricularly administered 5-hydroxytryptamine on normal and amine-depleted rabbit: subcellular distribution of 5-hydroxytryptamine in the brain stem, and animal behaviour

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