Effects of resistance training associated with whey protein supplementation on liver and kidney biomarkers in rats

Nunes, Ramiro Barcos; Silva, Priscila; Alves, Jadson Pereira; Stefani, Giuseppe Potrick; Rhoden, Cláudia Ramos; Lago, Pedro Dal; Schneider, Cláudia Dornelles

doi:10.1139/apnm-2013-0004

Cited by 8 publications

(9 citation statements)

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“…It is known that adiponectin is mainly expressed in adipose tissue, but a lower expression has also been reported for other tissues including skeletal muscle, cardiomyocytes, and liver [25]. The lower velocity training used in our study (22 and 28 m/min) was closer to that used by Gómez-Merino [23] compared to other studies that used repetitions at 65–75% from the maximal repetition test, reporting no effect of aerobic exercise training on BW in healthy rats [26]. The lower adiponectin concentration obtained in serum for MIT and HIT groups (Figure 1B) is consistent with previous data [27] and indicate a scarce negative effect of endurance exercise on serum adiponectin levels in healthy subjects or athletes [28].…”

Section: Discussionsupporting

confidence: 63%

Effects of Moderate- and High-Intensity Chronic Exercise on the Adiponectin Levels in Slow-Twitch and Fast-Twitch Muscles in Rats

et al. 2019

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Background and objectives: Adipose tissue and skeletal muscle secrete adiponectin, a hormone abundantly secreted by adipocytes, that through the adiponectin receptor, regulate glucose and lipid metabolism. Adiponectin appears to protect skeletal muscles from inflammatory damage induced by oxidative stress. It has been suggested that decreased adiponectin levels could be associated with pathologic conditions, including obesity and diabetes. Furthermore, some studies suggest that exercise could have a beneficial effect by increasing adiponectin levels, but this observation remains controversial. It is also unknown if physical exercise modifies adiponectin expression in skeletal muscles. The aim of this study was to investigate the effect of chronic exercise on serum adiponectin and adiponectin expression in slow-twitch (soleus) and fast-twitch (plantaris) muscles in healthy rats. Materials and methods: Two-month-old male Wistar rats were randomly divided into three groups with n = 6 in each group: control (C), moderate-intensity training (MIT), and high-intensity training (HIT). The rats were conditioned to run on a treadmill for the 8-week period. Forty-eight hours after the last session, blood samples were collected for adiponectin measurements and total RNA was isolated from plantaris and soleus muscles to measure by RT-qPCR adiponectin receptor 1 and adiponectin mRNA expression level. Results: MIT and HIT groups had reduced adiponectin protein levels in serum and the plantaris muscle, but not changes in adiponectin protein were observed in the soleus muscle. No significant differences in Adiponectin receptor 1 (AdipoR1) gene expression were observed following intense or moderate exercise in either muscle group studied. Conclusions: Our study shows that decreasing levels of circulating adiponectin is a result of physical exercise and should not be generalized as a predictive marker of disease.

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Section: Discussionsupporting

confidence: 63%

Effects of Moderate- and High-Intensity Chronic Exercise on the Adiponectin Levels in Slow-Twitch and Fast-Twitch Muscles in Rats

et al. 2019

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“…(M. A. [49]. In contrast, Manninen et al (2004) argue that there is no scientific evidence that a high-protein diet has any negative consequences on liver function [33].…”

Section: Discussionmentioning

confidence: 99%

Impact of nutritional protein supplements on liver and kidney functions among athletes attending gym

Mousa

Ali

2022

ijhs

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Whey protein is best recognized as a nutritional supplement that has been increasingly popular among gym users as the primary sports nutrition product used by athletes to improve exercise performance, body composition, and muscle growth. The types of supplements utilized can have a big impact on how athletes are treated medically. Two goals guide this work. To begin with, assess athletes' protein consumption. Second, we want to see if whey protein supplements alter the function of athletes' livers and kidneys. This is an analytical cross-sectional study conducted on 105 healthy male gym attendants in Al Nasiriyah city, Thi-Qar, Provence, south of Iraq, from June to November 2021. They were divided into two groups of athletes: group 1 (non-protein group) and group 2 (protein supplements group) with age of Mean ±SD of (27.56 ±8.31 years) and (29.26 ±7.35 years) respectively. The results indicate that athletes consume protein at a higher rate than the RDA for the general population, whether or not they utilize supplements. In terms of liver and renal function biomarkers, the results demonstrate no significant difference between the protein supplement group and the non-protein supplement group.

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“…Egzersiz ile birlikte whey protein alan grupta ise fizyolojik kardiyomyopati görülmüştür. 14 Bizim çalışmamızda ise düzenli ağırlık egzersizi ile birlikte alınan İHWP'nin alım öncesine göre karaciğer fonksiyon testlerini, üre ve T3'ü arttırdığı görülmüştür. Biz çalışmamızda, Nunes ve ark.…”

Section: Discussionunclassified

The Effect of Isolated Hydrolyzed Whey Protein on Thyroid Hormones, Liver and Kidney Function Tests in Individuals With Regular Weight Exercise

Akkurt¹

2019

Ankara Medical Journal

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Ağırlık egzersizi yapan bireylerin, protein gereksinimleri için düzenli olarak kullandıkları izole hidrolize whey proteininin tiroid fonksiyonu ve biyokimya parametreleri ile ilişkisinin değerlendirilmesi. Materyal ve Metot: Haziran 2018 -Şubat 2019 tarihleri arasında Sağlık Bilimleri Üniversitesi Numune Eğitim ve Araştırma Hastanesi Genel Cerrahi Polikliniğine kontrol amaçlı başvuran, en az 1 yıldır düzenli ağırlık egzersizi yapan ve protein gereksinimlerini karşılamak amacı ile günlük 30 gr hidrolize whey proteini kullanan 44 erkek birey çalışmaya dahil edildi. Çalışmaya dahil edilenlerin izole hidrolize whey proteini (İHWP) kullanmadan önceki ve İHWP kullanmaya başladıktan sonra 6. aydaki kontrol amaçlı alınan kan değerlerinden üre, kreatinin, AST, ALT, ALP, GGT, Total Bilüribin, Direk Bilirübin, TSH, T4, T3, Amilaz, Lipaz, Vitamin B12, D Vitamini, Hemoglobin değerleri ve bireylerin demografik verileri incelenerek bahsi geçen parametrelerin İHWP kullanımı öncesi ve sonrasında Shapiro-Wilk ve parametrik testler kullanılarak istatistiksel olarak anlamlı bir ilişkisi olup olmadığı değerlendirildi. Bulgular: Uygulanan bağımlı örneklem t testi sonucunda, VKI, kreatin, amilaz, T4, D vitamini, Hemogram değerinde zamana göre istatistiksel olarak anlamlı bir farklılık bulunmamakta iken Üre, AST, ALT, ALP, GGT, T.Bil, D.Bil, Lipaz, TSH, T3 ve B 12 vitamin değerlerinde ise istatistiksel olarak anlamlı derecede bir farklılık bulunmaktadır. Sonuç: Günümüzde vücut geliştirme amacı ile düzenli ağırlık egzersizi yapan bireylerde İHWP günlük protein alımını karşılamak için sıklıkla kullanılan bir suplement olarak karşımıza çıkmaktadır. Uzun süreli İHWP kullanımı sonucunda böbrek, karaciğer ve tiroid fonksiyonlarında birtakım değişiklikler görülebilmektedir. Düzenli olarak günlük İHWP tüketen bireylerin belli periyotlarda aile hekimlerinin kontrolünde olmaları ve aralıksız İHWP alımından kaçınılması kanaatindeyiz.

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Effects of resistance training associated with whey protein supplementation on liver and kidney biomarkers in rats

Cited by 8 publications

References 28 publications

Effects of Moderate- and High-Intensity Chronic Exercise on the Adiponectin Levels in Slow-Twitch and Fast-Twitch Muscles in Rats

Effects of Moderate- and High-Intensity Chronic Exercise on the Adiponectin Levels in Slow-Twitch and Fast-Twitch Muscles in Rats

Impact of nutritional protein supplements on liver and kidney functions among athletes attending gym

The Effect of Isolated Hydrolyzed Whey Protein on Thyroid Hormones, Liver and Kidney Function Tests in Individuals With Regular Weight Exercise

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