Effects of resistance training intensity on deformability and aggregation of red blood cells

Atabek, Hayriye Çakır; Atsak, Piray; Gündüz, Nihat; Bor-Küçükatay, Melek

doi:10.3233/ch-2009-1176

Cited by 30 publications

(33 citation statements)

References 20 publications

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“…Cakir-Atabek et al performed the first study investigating effects of resistance exercise training (RET) on RBC aggregation. Their findings indicating acute RET-induced increases in RBC aggregation, followed by slight decreases in the moderate intensity group after 6 weeks of RET are in agreement with the results of the current study [14]. The long-term decrease in RBC aggregation during PRET may be beneficial for tissue perfusion by decreasing resistance to flow and thus may also be related to the improvements observed in muscle strength after 12 weeks of training.…”

Section: Discussionsupporting

confidence: 92%

“…The short-term and chronic effects of RET performed at 2 different intensities (70% and 85% of 1-RM) on RBC deformability and aggregation were studied in our laboratory in physically active subjects who were not engaged in resistance training. RBC deformability was found to be increased immediately after the RET on the first and the last day of the program, but this augmentation was statistically significant only for the moderate intensity group on the first day [14]. The deformability results of our current study, which is the first one in the literature exploring the effects of PRET on hemorheology, are consistent with the findings of the above-mentioned study.…”

Section: Discussionsupporting

confidence: 89%

“…RET-induced post-exercise increases in RBC aggregation and deformability on the first and last day of both programs were demonstrated in this study. On the other hand, WBC, RBC, Hb and Hct values were significantly increased immediately after the RET on the first and last day of the program only in the moderate intensity group of subjects [14]. …”

Section: Introductionmentioning

confidence: 99%

“…Although previous studies have already presented some evidence of hemorheological and hematological alterations induced by RET [10,13,14], no information is available about the effects of PRET, which is widely used in clinics for taking highest level of advantage from RET, on hemorheological parameters. Therefore, the present study was designed to explore the acute and chronic effects of PRET performed at 12 weeks on hemorheological parameters in healthy, young, sedentary males.…”

Section: Introductionmentioning

confidence: 99%

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Hemorheological responses to progressive resistance exercise training in healthy young males

et al. 2012

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SummaryBackgroundThis study aimed to explore the effects of progressive resistance exercise training (PRET) on hemorheology.Material/MethodsExercise sessions included 1–3 sets of 8–12 repetitions at 40–60% of 1-repetition maximum (1-RM) for 3 weeks and at 75–80% of 1-RM during weeks 4–12. Red blood cell (RBC) deformability and aggregation were determined by ektacytometry, plasma and whole blood viscosities (WBV) by rotational viscometry. Lactate concentration was evaluated by an analyzer and fibrinogen was evaluated by coagulometry. Plasma total oxidant/antioxidant status was measured by colorimetry.ResultsFollowing an acute increase after exercise on the first day, RBC deformability was elevated during weeks 3 and 4 (p=0.028; p=0.034, respectively). The last exercise protocol applied in week 12 again caused an acute increase in this parameter (p=0.034). RBC aggregation was increased acutely on the first day, but decreased after that throughout the protocol (p<0.05). At weeks 4 and 12 pre-exercise measurements of WBV at standard hematocrit and plasma viscosity were decreased (p=0.05; p=0.041, respectively), while post-exercise values were increased (p=0.005; p=0.04, respectively). Post-exercise WBV at autologous hematocrit measured at week 12 was increased (p=0.01). Lactate was elevated after each exercise session (p<0.05). Fibrinogen was decreased on the third week (p<0.01), while it was increased on the 4th week (p=0.005). Plasma antioxidant status was increased at week 3 (p=0.034) and oxidative stress index was decreased at week 4 (p=0.013) after exercise.ConclusionsThe results of this study indicate that PRET may have positive effects on hemorheological parameters.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hemorheological responses to progressive resistance exercise training in healthy young males

et al. 2012

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“…In addition, several studies reported association between RBC aggregation abnormalities and diseases, probably as a consequence of inflammation and/or metabolic disturbances, such as in primary open-angle glaucoma [56], type 2 diabetes [75], insulin resistance [15,16], sickle cell disease [49,83,93] and others [32,48,58,79,95]. Few studies have investigated RBC aggregation in response to exercise and contrasting results have been reported: some studies described no change [25,84,89], an increase, in association or not with a rise in plasma fibrinogen level [18,36,84], or a delayed decrease [98] with exercise. Such findings should be considered in the context that in vitro assessment of RBC aggregation is typically performed on blood samples adjusted to standardised hematocrit (usually 40%); increased hematocrit observed during exercise likely increases RBC aggregation in vivo due to an increased cell-cell contact.…”

Section: Red Blood Cell Aggregationmentioning

confidence: 99%

Exercise hemorheology: Classical data, recent findings and unresolved issues

Connes

Simmonds

Brun

et al. 2013

Clinical Hemorheology and Microcirculation

125

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The present review focuses on the past and recent knowledge in the field of exercise hemorheology and presents some unresolved issues for opening discussion. Acute exercise is associated with a rise in hematocrit which results in an increase in blood viscosity. Whereas increased blood viscosity was previously viewed as having negative consequences for cardiovascular function and aerobic performance, recent findings suggest dynamic changes in blood viscosity might be useful for vascular function during exercise by increasing nitric oxide production. Other determinants of blood viscosity are altered by exercise (e.g., decreased red blood cell deformability, increased red blood cell aggregation and plasma viscosity) and may, independent of the associated effect on blood viscosity, directly modulate aerobic capacity. However, the data published on the effects of exercise on the hemorheology are not consistent, with some studies showing decreased, unchanged, or increased red blood cell deformability/aggregation when compared with rest. These discrepancies seem to be related to the exercise protocol investigated, the population tested or the methodogy utilized for hemorheological measurements. Finally, this review focuses on the effects of exercise training (i.e. chronic physical activity) on the hemorheological profile of healthy individuals and patients with cardiovascular and metabolic disorders. P. Connes et al. / Blood rheology and exerciseaddress classical findings in exercise hemorheology and will present new directions. In addition, some unresolved issues will be presented for opening discussion. Acute effects of exercise on hemorheology and relationships with performance2.1. Blood viscosity P. Connes et al. / Blood rheology and exercise 189 PRE 90 Blood viscosity (mPa/s) POST 90 POST 225 5 6 7 8 9

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Influence of a moderate physical activity intervention on red cell deformability in patients suffering from chronic obstructive pulmonary disease (COPD)

Ahmad

Ferrari

Montiel

et al. 2013

Wien Med Wochenschr

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The present study investigates whether a moderate physical activity intervention may alter red cell deformability (RCD) of patients suffering from chronic obstructive pulmonary disease (COPD). Subjects (n = 10; age: 62 ± 4; body-mass index (BMI): 25.8 ± 7.5) performed a training regimen for 10 weeks. In the beginning of the study and after the training period, COPD patients underwent a WHO cycle ergometry test. Venous blood samples were taken before (T0), immediately after (T1) and 30 min after (T2) the intervention. RCD was measured with the laser-assisted optical rotational cell analyzer (LORCA). Significant improvements of the RCD were detected. The semi-maximal shear stress increased significantly. Acute exhaustion had no effect on RCD. Thus, the training period of 10 weeks influenced RCD.

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Effects of resistance training intensity on deformability and aggregation of red blood cells

Cited by 30 publications

References 20 publications

Hemorheological responses to progressive resistance exercise training in healthy young males

Hemorheological responses to progressive resistance exercise training in healthy young males

Exercise hemorheology: Classical data, recent findings and unresolved issues

Influence of a moderate physical activity intervention on red cell deformability in patients suffering from chronic obstructive pulmonary disease (COPD)

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