Effects of resistance training on kidney morphology of aged ovariectomized rats

Marcelino, Marcelo Cristiano da Silva; Magalhães, Walkyria Villegas; Fonseca, Fernando L. A.; Nucci, Ricardo Aparecido Baptista; Maifrino, Laura Beatriz Mesiano

doi:10.1016/j.acthis.2020.151613

Cited by 3 publications

(2 citation statements)

References 21 publications

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“…The histological sections of the kidney were stained with HE. Measurements were made in the renal cortex based on the methods of Marcelino et al (2020) [33]. The areas of the corpuscle and the visceral layer were measured in 30 glomeruli per animal.…”

Section: Analysis Of Kidney Histologymentioning

confidence: 99%

A Rodent Model of Human-Dose-Equivalent 5-Fluorouracil: Toxicity in the Liver, Kidneys, and Lungs

et al. 2023

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5-Fluorouracil (5-FU) is a chemotherapy drug widely used to treat a range of cancer types, despite the recurrence of adverse reactions. Therefore, information on its side effects when administered at a clinically recommended dose is relevant. On this basis, we examined the effects of the 5-FU clinical treatment on the integrity of the liver, kidneys, and lungs of rats. For this purpose, 14 male Wistar rats were divided into treated and control groups and 5-FU was administered at 15 mg/kg (4 consecutive days), 6 mg/kg (4 alternate days), and 15 mg/kg on the 14th day. On the 15th day, blood, liver, kidney, and lung samples were collected for histological, oxidative stress, and inflammatory evaluations. We observed a reduction in the antioxidant markers and an increase in lipid hydroperoxides (LOOH) in the liver of treated animals. We also detected elevated levels of inflammatory markers, histological lesions, apoptotic cells, and aspartate aminotransferase. Clinical treatment with 5-FU did not promote inflammatory or oxidative alterations in the kidney samples; however, histological and biochemical changes were observed, including increased serum urea and uric acid. 5-FU reduces endogenous antioxidant defenses and increases LOOH levels in the lungs, suggesting oxidative stress. Inflammation and histopathological alterations were also detected. The clinical protocol of 5-FU promotes toxicity in the liver, kidneys, and lungs of healthy rats, resulting in different levels of histological and biochemical alterations. These results will be useful in the search for new adjuvants to attenuate the adverse effects of 5-FU in such organs.

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Section: Analysis Of Kidney Histologymentioning

confidence: 99%

A Rodent Model of Human-Dose-Equivalent 5-Fluorouracil: Toxicity in the Liver, Kidneys, and Lungs

et al. 2023

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“…We used the ladder climbing model for the strength training, as this model show effect in a variety of biological systems. [10][11][12][13][14] The training protocol was progressive with the load being adjusted every week. The load was composed of lead weights that were attached to their tails with tape.…”

Section: Resistance Training Protocolmentioning

confidence: 99%

Morphological and functional changes in urinary bladder of multiparous female rats submitted to resistance exercise

Moreno

Magaldi

et al. 2023

Rev. Fac. Ciênc. Méd. Sorocaba

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Objective: investigate whether resistance exercise can induce morphological and functional alterations in urinary bladder (UB) in multiparous rats. Methods: we used 40 adults female Wistar rats of which 20 were nulliparous and 20 were multiparous submitted to different volumes of moderate resistance exercise (one, three or ten weeks). Animals were submitted to the functional evaluation of UB. At the end of the protocol, the UB was removed, weighed and stained with hematoxylin and eosin for structural evaluation, and picrosirius red for collagen fibers. Results: we observed that multiparity promoted increase in body mass, reduction in UB layers, decrease in volume densities of collagen fibers I and III. However, 10-weeks of training was able to reverse the negative effects of multiparity. Conclusion: the intervention of physical exercise in 10 weeks times seems to cause greater benefit in UB of multiparous animals by preventing morphofunctional changes that trigger lower urinary tract symptoms, such as urinary loss.

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Comparative study of radioprotective effects of endurance training in irradiation-induced nephropathy of rat model

Parastesh,

Molavi,

Moghadasi

2024

Hormone Molecular Biology and Clinical Investigation

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Objectives Considering the antioxidant properties of endurance training, this study aimed to investigate the effects of endurance training on serum levels of oxidative stress and structural changes in the kidney tissue of rats exposed to X-ray irradiation. Methods In this experimental study, 24 rats weighing 220±20 g were randomly divided into four groups (healthy control, healthy with moderate-intensity continuous training, X-ray control, and X-ray with moderate-intensity continuous training). The two groups of rats were irradiated with 4 Gy X-rays. The two training groups also performed moderate-intensity continuous training for 10 weeks. Twenty-four hour after the last training session, the blood serum of rats was collected and kidney tissue was isolated for stereological studies. Results In this study, X-ray irradiation of the whole body of rats caused a significant increase in kidney volume, cortex volume, interstitial tissue volume, glomerular volume, and serum level of MDA (p≤0.05), but the medulla volume, volume of proximal tubules (total volume, volume of epithelium, and lumen), volume of distal tubules (total volume, volume of epithelium, and lumen), and the length of the proximal and distal tubules had no effect. In addition, TAC and SOD levels were significantly decreased in the radiation control group. Furthermore, performing endurance training in X-ray-irradiated rats significantly reduced kidney volume, cortex volume, glomerular volume, and serum MDA level (p≤0.05). Conclusions Moderate-intensity continuous training can improve the rate of destruction of kidney tissue in rats exposed to X-rays by reducing oxidative stress and subsequently increasing antioxidant capacity.

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Effects of resistance training on kidney morphology of aged ovariectomized rats

Cited by 3 publications

References 21 publications

A Rodent Model of Human-Dose-Equivalent 5-Fluorouracil: Toxicity in the Liver, Kidneys, and Lungs

A Rodent Model of Human-Dose-Equivalent 5-Fluorouracil: Toxicity in the Liver, Kidneys, and Lungs

Morphological and functional changes in urinary bladder of multiparous female rats submitted to resistance exercise

Comparative study of radioprotective effects of endurance training in irradiation-induced nephropathy of rat model

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