Effects of Resveratrol and Mangiferin on<i>PPARγ</i>and<i>FALDH</i>Gene Expressions in Adipose Tissue of Streptozotocin-Nicotinamide-Induced Diabetes in Rats

Sarkar, Purabi; Bhowmick, Ananya; Kalita, Mohan Chandra; Banu, Sofia

doi:10.1080/19390211.2018.1472714

Cited by 17 publications

(7 citation statements)

References 44 publications

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“…In addition, these antioxidant compounds frequently display actions on other factors implicated in diabetes, like inflammation, autophagy or β-cell proliferation [96,101,103,104,105]. A clear example is resveratrol, a polyphenol whose high antioxidant activity has been shown to prevent and protect against diabetes and its complications, as well as improving glucose homeostasis [106,107,108].…”

Section: Targeting Oxidative Stress In T2d: Evidence On the Use Ofmentioning

confidence: 99%

Relationship between Oxidative Stress, ER Stress, and Inflammation in Type 2 Diabetes: The Battle Continues

Burgos-Morón

Abad-Jiménez

Marañón

et al. 2019

JCM

401

299

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Type 2 diabetes (T2D) is a metabolic disorder characterized by hyperglycemia and insulin resistance in which oxidative stress is thought to be a primary cause. Considering that mitochondria are the main source of ROS, we have set out to provide a general overview on how oxidative stress is generated and related to T2D. Enhanced generation of reactive oxygen species (ROS) and oxidative stress occurs in mitochondria as a consequence of an overload of glucose and oxidative phosphorylation. Endoplasmic reticulum (ER) stress plays an important role in oxidative stress, as it is also a source of ROS. The tight interconnection between both organelles through mitochondrial-associated membranes (MAMs) means that the ROS generated in mitochondria promote ER stress. Therefore, a state of stress and mitochondrial dysfunction are consequences of this vicious cycle. The implication of mitochondria in insulin release and the exposure of pancreatic β-cells to hyperglycemia make them especially susceptible to oxidative stress and mitochondrial dysfunction. In fact, crosstalk between both mechanisms is related with alterations in glucose homeostasis and can lead to the diabetes-associated insulin-resistance status. In the present review, we discuss the current knowledge of the relationship between oxidative stress, mitochondria, ER stress, inflammation, and lipotoxicity in T2D.

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Section: Targeting Oxidative Stress In T2d: Evidence On the Use Ofmentioning

confidence: 99%

Relationship between Oxidative Stress, ER Stress, and Inflammation in Type 2 Diabetes: The Battle Continues

Burgos-Morón

Abad-Jiménez

Marañón

et al. 2019

JCM

401

299

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show abstract

“…49 Meanwhile, the prevention and protective effects of MGF on diabetes and its complications caused by oxidative stress, ROS, and insulin resistance were also collected. 50,51 2.3 Clinical randomized controlled trials of mangiferin on diabetes and diabetic complications Various in vitro and animal studies have shown that the MGF intake could improve diabetes and its complications, including insulin sensitivity, glycolipid metabolism disorders, diabetic nephropathy, cardiovascular disease, and cognitive performance. [52][53][54][55] Nevertheless, the medical effects as well as the clinical effects and implications of MGF need to be further explored and studied.…”

Section: Animal Studies On the Effects Of Mangiferin On Diabetes And ...mentioning

confidence: 99%

The management of diabetes mellitus by mangiferin: advances and prospects

et al. 2022

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“…PPARγ activation also increases antioxidant defence and regulates mitochondrial function [62]. FALDH is an enzyme that can metabolise 4-hydroxynonenal (HNE) and decrease HNE-induced ROS production [63]. Curcumin is a polyphenolic compound that has been shown to have anti-hyperglycaemic, anti-inflammatory, and antioxidant activity, attenuating DM complications [98].…”

Section: Natural Polyphenolsmentioning

confidence: 99%

The Use of Natural Compounds as a Strategy to Counteract Oxidative Stress in Animal Models of Diabetes Mellitus

Salazar–García

Corona

2021

IJMS

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Diabetes mellitus (DM) is a chronic metabolic disease characterised by insulin deficiency, resulting in hyperglycaemia, a characteristic symptom of type 2 diabetes mellitus (DM2). DM substantially affects numerous metabolic pathways, resulting in β-cell dysfunction, insulin resistance, abnormal blood glucose levels, impaired lipid metabolism, inflammatory processes, and excessive oxidative stress. Oxidative stress can affect the body’s normal physiological function and cause numerous cellular and molecular changes, such as mitochondrial dysfunction. Animal models are useful for exploring the cellular and molecular mechanisms of DM and improving novel therapeutics for their safe use in human beings. Due to their health benefits, there is significant interest in a wide range of natural compounds that can act as naturally occurring anti-diabetic compounds. Due to rodent models’ relatively similar physiology to humans and ease of handling and housing, they are widely used as pre-clinical models for studying several metabolic disorders. In this review, we analyse the currently available rodent animal models of DM and their advantages and disadvantages and highlight the potential anti-oxidative effects of natural compounds and their mechanisms of action.

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Effects of Resveratrol and Mangiferin onPPARγandFALDHGene Expressions in Adipose Tissue of Streptozotocin-Nicotinamide-Induced Diabetes in Rats

Cited by 17 publications

References 44 publications

Relationship between Oxidative Stress, ER Stress, and Inflammation in Type 2 Diabetes: The Battle Continues

Relationship between Oxidative Stress, ER Stress, and Inflammation in Type 2 Diabetes: The Battle Continues

The management of diabetes mellitus by mangiferin: advances and prospects

The Use of Natural Compounds as a Strategy to Counteract Oxidative Stress in Animal Models of Diabetes Mellitus

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