Effects of Resveratrol and Vitamin C on the Self-Renewal Capacity of Blast Progenitors in Hematologic Malignancies

Abstract

Oxidative stress is an imbalance between pro-oxidant and antioxidant factors that can lead to cellular damage [36]. Tumor suppressor genes regulate diverse cellular activities, including DNA damage repair, cell cycle arrest, mitogenic signaling, cell differentiation, migration, programmed cell death and senescence. Links between tumor suppressor genes and reactive oxygen species have been uncovered. In the present study, we investigated the effects of resveratrol and Vit-C on the growth of hematologic malignant blast progenitors in liquid suspension for up to one month. The cell cycle, type and rate of cellular stress responses, p21 and p27 trasncript levels and telomerase activity were also assessed.