Effects of resveratrol on high-fructose-induced testis injury in rats

Abstract

This study investigated whether a high-fructose (HFr) diet changes the morphology of seminiferous tubules (ST) in rats and resveratrol (RES) has a possible restoring effect in this sense. Fructose (30%; w/v) was administered to rats alone or together with RES (50 mg/L) in drinking water for 8 weeks. In the HFr group, destruction of the germinal epithelium led to the detection of immature germ cells in the lumen. HFr diet gave rise to a decrease in the ST diameters (p < 0.05), Johnsen's tubular biopsy score values (p < 0.001), and an increase in the apoptotic index (p < 0.05). Ultrastructurally, HFr feeding increased lipid accumulation (p < 0.01), mitochondrial damage, and acrosomal abnormalities in spermatogenic cells. Treatment of HFr -fed rats with RES improved the reduced ST diameters and overall general histological and ultrastructural abnormalities of the STs, but did not change the increased apoptotic index.

Effect of high-fructose diet-induced metabolic syndrome on the pituitary-gonadal axis from adolescence through adulthood in male albino rats and the possible protective role of ginger extract. A biochemical, histological and immunohistochemical study

“…This was consistent with the basement membrane irregularities detected by electron microscope and with the widened interstitial spaces. Similar results were reported by Meydanli et al [52].…”

“…Dyslipidemia, a characteristic component of MetS was proved in this study by the significant increase in serum TG and LDL and decrease in HDL. This reproduced the results of previous studies [52,72]. Basaranoglu et al [17] declared that chronic fructose ingestion favors hepatic lipogenesis, by providing large amounts of hepatic triosephosphate as precursors for fatty acid synthesis, thus increasing lipid accumulation in the liver as well as its secretion and an increase in blood content.…”

“…Basaranoglu et al [17] declared that chronic fructose ingestion favors hepatic lipogenesis, by providing large amounts of hepatic triosephosphate as precursors for fatty acid synthesis, thus increasing lipid accumulation in the liver as well as its secretion and an increase in blood content. This can explain accumulation of lipid droplets in the cytoplasm of Sertoli cells in the present study as clarified by Meydanli et al [52].…”

Luteolin Ameliorates Testis Injury and Blood–Testis Barrier Disruption through the Nrf2 Signaling Pathway and by Upregulating Cx43

“…Flavonoids are a group of compounds that are widely distributed in fruits and vegetables. Moreover, flavonoids, such as resveratrol, quercetin, and naringenin have been extensively investigated for the treatment of various types of testicular injury . In recent years, consuming vegetables and fruits containing luteolin has shown beneficial effects on the male reproductive system .…”

Dipeptidyl peptidase‐4 inhibition prevents cell death via extrinsic and intrinsic apoptotic pathways in rat pancreas with insulin resistance

“…There was no difference in calorie content. Meydanli et al suggested that chronic high‐fructose intake in healthy individuals may suppress food intake in the long‐term. Fructose is thought to be associated with appetite hormones, including insulin, leptin, and ghrelin .…”