Effects of Retrovirus Protein on the Feline One-way Mixed Leukocyte Reaction

Suppression of in vitro Neutrophil Function by Feline Leukaemia Virus (FeLV) and Purified FeLV-p15E

“…This suppression has been associated with direct viral infection of lymphoid tissue resulting in impairment of lymphoid function (Perryman et al, 1972). Immunization of cats with u.v.-inactivated FeLV (UV-FeLV) suppresses turnout immunity (Mathes et al, 1979) while allogeneic mixed leukocyte reactions in vitro are inhibited by UV-FeLV (Stiff & Olsen, 1983). Blastogenic responses of feline lymphocytes to concanavalin A (Con A) have been shown to be suppressed by as much as 65~ .…”

Feline Leukemia/Sarcoma Viruses and Immunodeficiency

“…Ultraviolet-inactivated FeLV (FeLV-UV) and protein from detergent-disrupted FeLV suppress the lymphocyte blastogenic responsiveness of peripheral blood mononuclear cells from normal cats (Langweiler et al, 1983). FeLV-UV causes significant suppression of the mixed leukocyte reaction (Stiff and Olsen, 1983) and of lymphokine secretion (Orosz et al, 1985). FeLV-UV causes significant suppression of the mixed leukocyte reaction (Stiff and Olsen, 1983) and of lymphokine secretion (Orosz et al, 1985).…”

Feline leukemia virus: current status of the feline induced immune depression and immunoprevention

“…Additional studies using purified proteins from FeLV show that a 15.000 dalton protein from the envelope of the virus is able to inhibit lectin and antigen-induced mitogcncsis of both cat and human lymphocytes [50--52]. These initial studies concentrated on lymphocyte functions such as lectin-induced mitogenesis [49,52], antigen-induced mitogenesis [50], mixed lymphocyte reaction [53], and lectin receptor mobility [14,54], all of which are deficient in FcLV-infccted cats and can be mimicked in vitro with UV-FeLV or FeLV-pI5E. In vivo studies have also shown that both UV-FcLV and FelN-pl5E can suppress humoral antibody development [48,52].…”