Effects of rhynchophylline on the hippocampal miRNA expression profile in ketamine-addicted rats

Li, Chan; Tu, Genghong; Luo, Chaohua; Guo, Youli; Miao, Fei; Zhu, Chen; Li, Hancheng; Ou, Jinying; Zhou, Yuting; Liu, Wei; Yung, Kin Lam; Mo, Zhixian

doi:10.1016/j.pnpbp.2018.02.009

Cited by 23 publications

(8 citation statements)

References 38 publications

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“…The CPP apparatus used was similar to that used in our previous studies [ 37 ]. Briefly, the CPP apparatus was divided into two equally sized compartments by a mobile partition.…”

Section: Methodsmentioning

confidence: 99%

Sinomenine Protects Against Morphine Dependence through the NMDAR1/CAMKII/CREB Pathway: A Possible Role of Astrocyte-Derived Exosomes

Zhou

et al. 2018

Molecules

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Sinomenine is a nonaddictive alkaloid used to prevent morphine dependence, even thoughits mechanism isnot fully understood. Astrocytes aggravate the pathological process in their neighboring cellsthrough exosomes in central nervous system diseases. However, the effect of sinomenine on astrocyte-derived exosomes for the amelioration of morphine dependence has not been reported yet. In this study, we found that sinomenine prevented the morphine-induced conditionedplace preference in mice. Sinomenine reduced the levels of cAMP and intracellular Ca2+ in morphine-treated SH-SY5Y cells. Moreover, sinomenine inhibited the expressions of p-NMDAR1/NMDAR1, p-CAMKII/CAMKII, and p-CREB/CREB in the hippocampusof morphine-dependent mice and SH-SY5Y cells. Furthermore, we found that sinomenine inhibitedthe morphine-induced activation of astrocytesin vivo and in vitro. Afterwards, exosomes were isolated from cultured primary astrocytes treated with phosphate buffer saline (PBS, ctl-exo), morphine (mor-exo), or morphine and sinomenine (Sino-exo). Subsequently, morphine-treated SH-SY5Y cells were treated with ctl-exo, mor-exo, and Sino-exo. Results showed that Sino-exo reduced the level of cAMP, intracellular Ca2+, and the expression of p-CAMKII/CAMKII and p-CREB/CREB in morphine-treated SH-SY5Y cells. In conclusion, we demonstrated that sinomenine exhibited protective effects against morphine dependencein vivo and in vitro through theNMDAR1/CAMKII/CREB pathway. Sinomenine-induced alterationof the function of astrocyte-derived exosomes may contribute to the antidependence effects of sinomenine in morphine dependence.

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“…The CPP apparatus used was similar to that used in our previous studies [ 37 ]. Briefly, the CPP apparatus was divided into two equally sized compartments by a mobile partition.…”

Section: Methodsmentioning

confidence: 99%

Sinomenine Protects Against Morphine Dependence through the NMDAR1/CAMKII/CREB Pathway: A Possible Role of Astrocyte-Derived Exosomes

Zhou

et al. 2018

Molecules

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“…In a rat model of epilepsy, kainic acid was found to increase BDNF protein in the cerebral cortex and hippocampus, which was attenuated by Rhy or Uncaria [ 85 ]. Similarly, ketamine-addicted rats were shown to have an increased expression of BDNF in the hippocampus, which was diminished by Rhy [ 21 , 92 ]. Rhy was also observed to reduce the levels of extracellular and intracellular BDNF in human bone marrow mesenchymal cells [ 78 ].…”

Section: Rhy Targets and Links To Sleep Regulationmentioning

confidence: 99%

“…Attenuates amph-induced ↑ in CPP, glutamic acid, DA, and NE Attenuates amph-induced ↓ in GABA, endorphin, and ACh[91] Attenuates ketamine-induced ↑ in CPP, Nr4a2 and Bdnf mRNAs, NURR1, BDNF, p-CREB (all hipp. )[21,92] Attenuates amph-induced ↑ in CPP and Grin2b mRNA, and GluN2B protein in mPFC and CA1[20] Attenuates meth-induced ↑ in CPP and GluN2B↓ brain infarction and neurological deficits in a stroke model In cerebral cortex: Accentuates ischemia-induced ↑ in p-AKT and p-mTOR Attenuates ischemia-induced ↑ in TLR2,4, MyD88, caspase 3, and nuclear NF-κB Attenuates stroke-induced ↓ in p-BAD, BDNF, Bdnf p-NF-κB p65, p-IkBα, TLR2, caspase1, MyD88, DA, D2R (in striatum) Attenuates DOI-induced ↓ in p-TrkB, BDNF (in striatum), and cell viability Rats [96,97] Attenuates asthma-induced ↑ in eosinophil recruitment, IL-13, IL-4, IL-5 in serum Attenuates asthma-induced ↑ TGFβ, Smad4, p-Smad2, p-Smad3, p-ERK1/2 and p-38 in lung tissue * Attenuates cardiac hypertrophy-induced ↑ in TGFβ1, cTGF, Collagen 1,3 , p-ERK, p-38, p-JNK, and attenuates the induced ↓ in SOD2 * ↑ NRF2 and accentuates the induced ↑ in SOD3 Mice [101]…”

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confidence: 99%

Cellular Effects of Rhynchophylline and Relevance to Sleep Regulation

et al. 2021

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Uncaria rhynchophylla is a plant highly used in the traditional Chinese and Japanese medicines. It has numerous health benefits, which are often attributed to its alkaloid components. Recent studies in humans show that drugs containing Uncaria ameliorate sleep quality and increase sleep time, both in physiological and pathological conditions. Rhynchophylline (Rhy) is one of the principal alkaloids in Uncaria species. Although treatment with Rhy alone has not been tested in humans, observations in rodents show that Rhy increases sleep time. However, the mechanisms by which Rhy could modulate sleep have not been comprehensively described. In this review, we are highlighting cellular pathways that are shown to be targeted by Rhy and which are also known for their implications in the regulation of wakefulness and sleep. We conclude that Rhy can impact sleep through mechanisms involving ion channels, N-methyl-d-aspartate (NMDA) receptors, tyrosine kinase receptors, extracellular signal-regulated kinases (ERK)/mitogen-activated protein kinases (MAPK), phosphoinositide 3-kinase (PI3K)/RAC serine/threonine-protein kinase (AKT), and nuclear factor-kappa B (NF-κB) pathways. In modulating multiple cellular responses, Rhy impacts neuronal communication in a way that could have substantial effects on sleep phenotypes. Thus, understanding the mechanisms of action of Rhy will have implications for sleep pharmacology.

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“…In addition, Nurr1 heterozygous mice exhibited reduced reward-seeking behaviors mediated by dopaminergic neurotransmission and were vulnerable to neurodegeneration during long-term methamphetamine administration [14,231]. In contrast, the hippocampus of ketamine-addicted rats has been reported to show increased levels of Nurr1 due to CREB-medicated phosphorylation [232,233]. These studies suggest that Nurr1 is involved in the initiation and progression of addictive disorders, which may depend on the type of drug and the duration of administration.…”

Section: Addictive Behaviorsmentioning

confidence: 99%

The Critical Role of Nurr1 as a Mediator and Therapeutic Target in Alzheimer’s Disease-related Pathogenesis

et al. 2020

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Several studies have revealed that the transcription factor nuclear receptor related 1 (Nurr1) plays several roles not only in the regulation of gene expression related to dopamine synthesis, but also in alternative splicing, and miRNA targeting. Moreover, it regulates cognitive functions and protects against inflammationinduced neuronal death. In particular, the role of Nurr1 in the pathogenesis of Parkinson's disease (PD) has been well investigated; for example, it has been shown that it restores behavioral and histological impairments in PD models. Although many studies have evaluated the connection between Nurr1 and PD pathogenesis, the role of Nurr1 in Alzheimer's disease (AD) remain to be studied. There have been several studies describing Nurr1 protein expression in the AD brain. However, only a few studies have examined the role of Nurr1 in the context of AD. Therefore, in this review, we highlight the overall effects of Nurr1 under the neuropathologic conditions related to AD. Furthermore, we suggest the possibility of using Nurr1 as a therapeutic target for AD or other neurodegenerative disorders.

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Effects of rhynchophylline on the hippocampal miRNA expression profile in ketamine-addicted rats

Cited by 23 publications

References 38 publications

Sinomenine Protects Against Morphine Dependence through the NMDAR1/CAMKII/CREB Pathway: A Possible Role of Astrocyte-Derived Exosomes

Sinomenine Protects Against Morphine Dependence through the NMDAR1/CAMKII/CREB Pathway: A Possible Role of Astrocyte-Derived Exosomes

Cellular Effects of Rhynchophylline and Relevance to Sleep Regulation

The Critical Role of Nurr1 as a Mediator and Therapeutic Target in Alzheimer’s Disease-related Pathogenesis

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