Effects of risedronate on bone marrow adipocytes in postmenopausal women

Duque, Gustavo; Li, W.; Adams, Mildred; Xu, Shaonan; Phipps, Roger J.

doi:10.1007/s00198-010-1353-8

Cited by 63 publications

(28 citation statements)

References 33 publications

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“…In women with lower than median femoral neck marrow fat content, BMD declined 1.6 %, compared with 4.7 % in those with higher than median marrow fat content. Other longitudinal studies show that marrow fat decreases with osteoporosis treatments, such as transdermal estrogen [21] and risedronate [22], providing additional support for an inverse relationship between marrow fat and bone. Marrow fat also correlates with prevalent fracture [19], independent of BMD [23••, 24], suggesting that marrow fat relates not only to bone mass but also to additional contributors to skeletal strength.…”

Section: Marrow Fat Is Negatively Associated With Bonementioning

confidence: 98%

Diabetes and Bone Marrow Adiposity

Kim

Schafer

2016

Curr Osteoporos Rep

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Purpose of Review This study aims to describe bone marrow fat changes in diabetes and to discuss the potential role of marrow fat in skeletal fragility. Recent Findings Advances in non-invasive imaging have facilitated marrow fat research in humans. In contrast to animal studies which clearly demonstrate higher levels of marrow fat in diabetes, human studies have shown smaller and less certain differences. Marrow fat has been reported to correlate with A1c, and there may be a distinct marrow lipid saturation profile in diabetes. Summary Greater marrow fat is associated with impaired skeletal health. Marrow fat may be a mediator of skeletal fragility in diabetes. Circulating lipids, growth hormone alterations, visceral adiposity, and hypoleptinemia have been associated with greater marrow fat and may represent potential mechanisms for the putative effects of diabetes on marrow fat, although other factors likely contribute. Additional research is needed to further define the role of marrow fat in diabetic skeletal fragility and to determine whether marrow fat is a therapeutic target.

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Section: Marrow Fat Is Negatively Associated With Bonementioning

confidence: 98%

Diabetes and Bone Marrow Adiposity

Kim

Schafer

2016

Curr Osteoporos Rep

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“…Intriguingly, a number of antiresorptive and anabolic drugs that increase bone mass also exhibit a general inverse relationship with bone marrow fat [97–102]. For example, despite the therapeutic benefits of bisphosphonates being directed toward osteoclast inhibition, certain drugs within this class, including residronate and zoledronic acid, suppress bone marrow fat [97–99]. In addition, anabolic agents that target osteoblast development/function have also been shown to reduce marrow fat formation [100–102].…”

Section: Impact Of Therapeutic Drugs On Bone Remodelingmentioning

confidence: 99%

Bone Marrow Adipose Tissue and Skeletal Health

Muruganandan

Govindarajan

Sinal

2018

Curr Osteoporos Rep

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Purpose of Review To summarize and discuss recent progress and novel signaling mechanisms relevant to bone marrow adipocyte formation and its physiological/pathophysiological implications for bone remodeling. Recent Findings Skeletal remodeling is a coordinated process entailing removal of old bone and formation of new bone. Several bone loss disorders such as osteoporosis are commonly associated with increased bone marrow adipose tissue. Experimental and clinical evidence supports that a reduction in osteoblastogenesis from mesenchymal stem cells at the expense of adipogenesis, as well as the deleterious effects of adipocyte-derived signaling, contributes to the etiology of osteoporosis as well as bone loss associated with aging, diabetes mellitus, post-menopause, and chronic drug therapy. However, this view is challenged by findings indicating that, in some contexts, bone marrow adipose tissue may have a beneficial impact on skeletal health. Summary Further research is needed to better define the role of marrow adipocytes in bone physiology/pathophysiology and to determine the therapeutic potential of manipulating mesenchymal stem cell differentiation.

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“…Transiliac biopsies of premenopausal women with idiopathic osteoporosis or osteopenia revealed more numerous, voluminous marrow adipocytes compared to controls, although only controls had the expected positive correlation of MAT and age and negative correlations of MAT, bone formation and bone volume. (25) A recent study in the AGES-Reykjavik cohort found that higher MAT was negatively related to trabecular BMD measured by QCT in women, and positively related to existing vertebral fractures in men. (18)Both osteoporosis and osteopenia were associated with a lower proportion of unsaturated lipid, as assessed by proton magnetic resonance spectroscopy ((1)H-MRS).…”

Section: Overview and Fundamental Questionsmentioning

confidence: 99%

The bone–fat interface: basic and clinical implications of marrow adiposity

Devlin

Rosen

2015

The Lancet Diabetes & Endocrinology

213

159

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Obesity and osteoporosis are two of the most common chronic disorders of the 21st century. Both are accompanied by significant morbidity. The only place in the mammalian organism where bone and fat lie adjacent to each other is in the bone marrow. Marrow adipose tissue is a dynamic depot that likely exists as both constitutive and regulated compartments. Adipocytes secrete cytokines and adipokines that either stimulate or inhibit adjacent osteoblasts. The relationship of marrow adipose to other fat depots is complex and may play very distinct roles in modulating metabolic homeostasis, hematopoiesis and osteogenesis. Understanding the relationship between bone and fat cells that arise from the same progenitor within the ‘niche’ provides insight into the pathophysiology of age-related osteoporosis, diabetes mellitus and obesity.

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Effects of risedronate on bone marrow adipocytes in postmenopausal women

Cited by 63 publications

References 33 publications

Diabetes and Bone Marrow Adiposity

Diabetes and Bone Marrow Adiposity

Bone Marrow Adipose Tissue and Skeletal Health

The bone–fat interface: basic and clinical implications of marrow adiposity

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