Effects of Rosiglitazone on Metabolic Parameters and Adiponectin Levels in Fructose-Fed Rats

Atanasovska, Emilija; Jakovski, Krume; Kostova, Elena; Petlichkovski, Aleksandar; Dimitrovski, Chedo; Bitovska, Iskra; Kikerkov, Igor; Petrovski, Ognen; Labachevski, Nikola

doi:10.3889/mjms.1857-5773.2009.0037

Cited by 2 publications

(1 citation statement)

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“…Fructose feeding is an established experimental model for inducing the metabolic syndrome in rats [ 10 , 11 ]; however, studies vary significantly in fructose delivery and the administered concentration. The concentration of fructose administered as a component of chow itself is generally supraphysiological and ranges between 60%–70% w / w or 0.6–0.7 g/g chow [ 10 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 ], whereas the concentration of fructose beverages can often vary anywhere between 10%–30% w / v or 0.1–0.3 g fructose/mL water [ 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 ]. Despite the reported effects on metabolic health, studies investigating the effect of high concentrations of fructose in chow or as a beverage report no effect of fructose consumption on rodent body weight [ 10 , 12 , 46 , 47 ], while others report an increase in body weight [ 22 , 23 , 27 , 29 , ...…”

Section: Introductionmentioning

confidence: 99%

Fructose Beverage Consumption Induces a Metabolic Syndrome Phenotype in the Rat: A Systematic Review and Meta-Analysis

2016

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A high intake of refined carbohydrates, particularly the monosaccharide fructose, has been attributed to the growing epidemics of obesity and type-2 diabetes. Animal studies have helped elucidate the metabolic effects of dietary fructose, however, variations in study design make it difficult to draw conclusions. The aim of this study was to review the effects of fructose beverage consumption on body weight, systolic blood pressure and blood glucose, insulin and triglyceride concentrations in validated rat models. We searched Ovid Embase Classic + EmbaseMedline and Ovid Medline databases and included studies that used adolescent/adult male rats, with fructose beverage consumption for >3 weeks. Data from 26 studies were pooled by an inverse variance weighting method using random effects models, expressed as standardized mean differences (SMD) with 95% confidence intervals (CI). Overall, 10%–21% w/v fructose beverage consumption was associated with increased rodent body weight (SMD, 0.62 (95% CI: 0.18, 1.06)), systolic blood pressure (SMD, 2.94 (95% CI: 2.10, 3.77)) and blood glucose (SMD, 0.77 (95% CI: 0.36, 1.19)), insulin (SMD, 2.32 (95% CI: 1.57, 3.07)) and triglyceride (SMD, 1.87 (95% CI: 1.39, 2.34)) concentrations. Therefore, the consumption of a low concentration fructose beverage is sufficient to cause early signs of the metabolic syndrome in adult rats.

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