Effects of rosmarinic acid on immunoregulatory activity and hepatocellular carcinoma cell apoptosis in<i>H22</i>tumor-bearing mice

Cao, Wen; Mo, Kai; Wei, Sijun; Lan, Xiaobu; Zhang, Wenjuan; Jiang, Weizhe

doi:10.4196/kjpp.2019.23.6.501

Cited by 16 publications

(8 citation statements)

References 29 publications

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“…However, the authors state that the antioxidative and anti-inflammatory activity of either carnosic acid or carnosol alone is weaker than that of rosemary extract [ 87 ]. Other authors speculate that rosmarinic acid might exhibit an anti-inflammatory activity by inhibition of neutrophil activity, inhibition of MMP-9 activity, and modulation of the NF-κB pathway [ 88 ], accordingly to our findings [ 47 , 48 , 49 , 50 , 51 ].…”

Section: Resultssupporting

confidence: 88%

Potential Anti-Inflammatory Effect of Rosmarinus officinalis in Preclinical In Vivo Models of Inflammation

et al. 2022

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This systematic review aimed to evaluate the potential anti-inflammatory effect of Rosmarinus officinalis in preclinical in vivo models of inflammation. A search was conducted in the databases PubMed, Scopus, and Web of Science, with related keywords. The inclusion criteria were inflammation, plant, and studies on rats or mice; while, the exclusion criteria were reviews, studies with in vitro models, and associated plants. The predominant animal models were paw edema, acute liver injury, and asthma. Rosemary was more commonly used in its entirety than in compounds, and the prevalent methods of extraction were maceration and hydrodistillation. The most common routes of administration reported were gavage, intraperitoneal, and oral, on a route-dependent dosage. Treatment took place daily, or was single-dose, on average for 21 days, and it more often started before the induction. The most evaluated biomarkers were tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, IL-10, myeloperoxidase (MPO), catalase (CAT), glutathione (GSH), glutathione peroxidase (GPx), malondialdehyde (MDA), and superoxide dismutase (SOD). The best results emerged at a dose of 60 mg/kg, via IP of carnosic acid, a dose of 400 mg/kg via gavage of Rosmarinus officinalis, and a dose of 10 mg/kg via IP of rosmarinic acid. Rosmarinus officinalis L. showed anti-inflammatory activity before and after induction of treatments.

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Section: Resultssupporting

confidence: 88%

Potential Anti-Inflammatory Effect of Rosmarinus officinalis in Preclinical In Vivo Models of Inflammation

et al. 2022

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“…In recent years, many traditional Chinese medicines, as well as monomeric compounds extracted from certain Chinese medicines, such as phenylpropanoids, flavonoids, saccharides, and alkaloids, have demonstrated outstanding antitumor effects [23]. Researchers have also found that many traditional herbal medicines and molecular compounds derived from herbs show high efficacy in HCC treatment, which can significantly reduce the clinical symptoms and prolong the survival rate of these patients [24]. Our previous studies have confirmed that FZXLG can improve clinical efficacy in patients with HCC after comprehensive minimally invasive treatment as well as liver function and quality of life [25], but high-quality randomized controlled trials are lacking.…”

Section: Discussionmentioning

confidence: 99%

Fuzheng Xiaoliu granules reduce the 2-year recurrence rate of early-stage hepatitis B virus-related hepatocellular carcinoma after comprehensive minimally invasive surgery: a study protocol for a prospective, multicenter, central randomized, double-blind, placebo-controlled clinical trial

Chen¹,

Ma²,

Hao³

et al. 2021

Preprint

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Background: Hepatitis B virus (HBV) infection is one of the most common risk factors for hepatocellular carcinoma (HCC). With the continuous improvement of minimally invasive treatment techniques such as transarterial chemoembolization (TACE) and radiofrequency ablation (RFA), comprehensive minimally invasive treatment (TACE & RFA) has been widely used in the treatment of early-stage (Barcelona Clinic Liver Cancer (BCLC) stage 0 and A) HCC and has good safety and clinical efficacy. However, recurrence and metastasis after comprehensive minimally invasive treatment are still key factors affecting the survival rate of patients. In recent years, Chinese medicine has highlighted its unique advantages in the adjuvant treatment of liver cancer surgery and minimally invasive treatment. Thus, this study aimed to evaluate the efficacy and safety of Fuzheng Xiaoliu granules (FZXLG) for treating early-stage HBV-related HCC after comprehensive minimally invasive treatment and to explore whether FZXLG can delay the progression of HBV-related HCC. Methods: This is a prospective, multicenter, central randomized, double-blind, placebo-controlled clinical trial. A total of 312 patients with early HBV-related HCC who underwent comprehensive minimally invasive treatment within 2 months were randomized in a 1:1 ratio into two groups: the experimental group and the control group. The experimental group will receive basic FZXLG plus Western medicine treatment, and the control group will receive basic FZXLG simulator plus Western medicine treatment. Each group will be treated for 1 year and followed-up for 1 year. The primary outcome measure is the 2-year recurrence rate of patients with early-stage HBV-related HCC after minimally invasive treatment. The secondary outcomes include (1) measurable active lesions, (2) alpha-fetoprotein (AFP), (3) immunological indicators, such as comparison of CD3+, CD4+, CD8+ absolute values, CD4+/CD8+ before and after the test, (4) hepatitis B virus quantity, and (5) Karnofsky functional status score. Discussion: These results will provide research data on the efficacy and safety of FZXLG for the treatment of early-stage HBV-related HCC after comprehensive minimally invasive treatment. These findings will also be based on laboratory indicators and adverse events for safety assessment to determine whether FZXLG can reduce the 2-year recurrence rate of HCC after minimally invasive surgery, which will provide reliable evidence for the clinical treatment of HCC.Trial registration: Chinese Clinical Trial Registry, ChiCTR1900022999. Registered on 5 May 2019.

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“…RA oral administration to DMBA treated mice repair the expression of p53, Bcl-2, Bax, caspase-3 and 9, indicating that RA may have facilitate or motivate the process of apoptosis during DMBA induced skin carcinogenesis. Cao et al, 2019 (48) attributed chemopreventive mechanism to RA exerts pro-apoptotic effects by inhibiting of STAT3 pathway, thereby upregulating Bax and down-regulating Bcl-2. Nadeem et al, 2019 (49) suggested that, RA's anti-angiogenic effects, as demonstrated through human umbilical vein endothelial cells proliferation, migration, adhesion, and tube formation inhibition.…”

Section: Discussionmentioning

confidence: 99%

Effect of rosmarinic acid as a chemopreventive modality on experimentally induced hamster buccal pouch carcinogenesis

Al-Wahab

Gobran

Dameer

2020

Egyptian Dental Journal

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Aim: It was directed to evaluate rosmarinic acid (RA) effect as a chemopreventive modality on experimentally induced hamster buccal pouch (HBP) carcinogenesis. Material and methods: Forty Syrian male hamsters five weeks old, weighing 120-80g, were divided into four groups of ten hamsters in each as follows, GI: Only topical application of liquid paraffin (3 times a week for 14 weeks), GII: Topical application of 12 ,7 dimethyl benz[a]anthracene (DMBA) alone (%0.5 in liquid paraffin, 3 times a week for 14 weeks), GIII: Topical application of DMBA (%0.5 in liquid paraffin, 3 times a week for 14 weeks) associated by oral administration of RA (100mg/kg b.w in 1ml distilled water by oral gavage, 3 times a week for 14 weeks on opposite days of DMBA application), GIV : Oral administration of RA alone (100mg/kg b.w in 1ml distilled water by oral gavage, 3 times a week for 14 weeks). Results: Gross observation and histopathological findings revealed a-GI: normal stratified squamous epithelium b-GII: well and moderately differentiated SCC c-: GIII: revealed considerably reversed tumor incidence d: GIV: normal similar to GI. Immunohistochemical results revealed, oral administration of RA to DMBA treated hamsters restored the normal expression of bcl2-and Bax indicating that RA may have chemopreventive mechanism and/or pro-apoptotic effects. Conclusion: RA may act through different mechanisms, such as applying anti-inflammatory, antioxidant results as well as impede cell proliferation, migration, and selectively convince cancer cells apoptosis.

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Effects of rosmarinic acid on immunoregulatory activity and hepatocellular carcinoma cell apoptosis inH22tumor-bearing mice

Cited by 16 publications

References 29 publications

Potential Anti-Inflammatory Effect of Rosmarinus officinalis in Preclinical In Vivo Models of Inflammation

Potential Anti-Inflammatory Effect of Rosmarinus officinalis in Preclinical In Vivo Models of Inflammation

Fuzheng Xiaoliu granules reduce the 2-year recurrence rate of early-stage hepatitis B virus-related hepatocellular carcinoma after comprehensive minimally invasive surgery: a study protocol for a prospective, multicenter, central randomized, double-blind, placebo-controlled clinical trial

Effect of rosmarinic acid as a chemopreventive modality on experimentally induced hamster buccal pouch carcinogenesis

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