Effects of Rosuvastatin on the expression of the genes involved in cholesterol metabolism in rats: adaptive responses by extrahepatic tissues

Ahmadi, Yasin; Haghjoo, Amir Ghorbani; Dastmalchi, Siavoush; Nemati, Mahboob; Bargahi, Nasrin

doi:10.1016/j.gene.2018.03.092

Cited by 6 publications

(4 citation statements)

References 32 publications

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“…Statins present some hepatotoxicity potential, by increasing apoptosis in cultured human hepatocytes and oxidative stress in the liver ( Beltowski et al, 2009 ), but in the current study, the increased liver weight might have been associated with its adaptation to the rosuvastatin exposure, because alterations in this parameter were not found after long-term exposure, on PND 75. Ahmadi et al ( Ahmadi et al, 2018 ) show that rosuvastatin exposure in rats is related to a compensatory mechanism in cholesterol biosynthesis and metabolism in the liver and extrahepatic tissues, which bolsters the idea of adaptive response by the liver to the statin.…”

Section: Discussionmentioning

confidence: 91%

Short- and long-term effects on reproductive parameters of female Wistar rats after exposure to rosuvastatin starting in pre-puberty

Barros

Tonon

Borges

et al. 2020

Current Research in Toxicology

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Section: Discussionmentioning

confidence: 91%

Short- and long-term effects on reproductive parameters of female Wistar rats after exposure to rosuvastatin starting in pre-puberty

Barros

Tonon

Borges

et al. 2020

Current Research in Toxicology

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“…Indeed, rosuvastatin illustrated a dose-dependent effect in the improvement of lipid profile and Atherogenic Index suggesting that rosuvastatin may alleviate the bad influence of HFD on lipid metabolism. [24]…”

Section: Discussionmentioning

confidence: 99%

Effects of rosuvastatin on metabolic profile: Versatility of dose-dependent effect

Al-Kuraishy

Al-Gareeb

2019

J Adv Pharm Technol Res

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Obesity refers to an excess of body fat content causing metabolic and inflammatory disorders. Therefore, the aim of the present study was to investigate dose-dependent effect of rosuvastatin on the metabolic profile of diet-induced obesity in mice model study. A total number of 40 male Albino Swiss mice were used which divided into Group I: Control group, fed normal diet for 8 weeks ( n = 10); Group II: High-fat diet (HFD) group, fed on HFD for 8 weeks ( n = 10); Group III: HFD + 20 mg/kg rosuvastatin for 8 weeks ( n = 10); and Group IV: HFD +40 mg/kg rosuvastatin for 8 weeks ( n = 10). Anthropometric and biochemical parameters were estimated, including fasting blood glucose, lipid profile, fasting insulin, and glucose tolerance test (GTT). Mice on HFD fed showed a significant increase in the insulin resistance, body weight, deterioration of lipid profile and significant reduction in the β-cell function, and insulin sensitivity compared to the control P < 0.05. GTT and blood glucose level were significantly high in HFD fed group compared to the control group P < 0.05. Rosuvastatin in a dose of 40 mg/kg illustrated better effect than 20 mg/kg on the glucometabolic profile P < 0.05. Rosuvastatin may has a potential effect on reduction of glucometabolic changes induced by HFD with significant amelioration of pancreatic β-cell function in dose-dependent manner.

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“…The liver and the small intestine are the two most critical organs involved in the entire process of cholesterol metabolism (Ahmadi et al 2018). The function of the liver includes the synthesis of cholesterol, conversion into bile acids, and lipid reabsorption and metabolism in the body.…”

Section: Cholesterol Metabolismmentioning

confidence: 99%

Research progress in lipid metabolic regulation of bioactive peptides

Lin

et al. 2023

Food Prod Process and Nutr

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Hyperlipidemia poses a serious threat to human health and evaluating the ability of natural active substances to regulate disorders of lipid metabolism is the focus of food functionality research in recent years. Bioactive peptides are distinguished by their broad range of sources, high nutritional content, ease of absorption and use by the body, and ease of determining their sequences. Bioactive peptides have a wide range of potential applications in the area of medicines and food. The regulation of lipid metabolism disorder caused by bioactive peptides from different sources provides a reference for the development and research of bioactive peptides for lipid reduction. Graphical Abstract

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Effects of Rosuvastatin on the expression of the genes involved in cholesterol metabolism in rats: adaptive responses by extrahepatic tissues

Cited by 6 publications

References 32 publications

Short- and long-term effects on reproductive parameters of female Wistar rats after exposure to rosuvastatin starting in pre-puberty

Short- and long-term effects on reproductive parameters of female Wistar rats after exposure to rosuvastatin starting in pre-puberty

Effects of rosuvastatin on metabolic profile: Versatility of dose-dependent effect

Research progress in lipid metabolic regulation of bioactive peptides

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