Effects of Roux-en-Y Gastric Bypass on Resting Energy Expenditure in Women

César, Marcelo de Castro; Montebelo, Maria Imaculada de Lima; Rasera, Irineu; Oliveira, Adalberto Vicente de; Gonelli, Pamela Roberta Gomes; Cardoso, J.R.

doi:10.1007/s11695-008-9460-8

Cited by 54 publications

(25 citation statements)

References 18 publications

(25 reference statements)

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“…The human literature is not entirely consistent in respect to RYGB-induced changes in overall energy expenditure (23,31,32,42,152,153). A recent review indicated that total energy expenditure in humans often decreases due to the decrease in fat-free and fat mass but that diet-induced thermogenesis is often increased (please see also below) (145).…”

Section: Energy Expenditurementioning

confidence: 99%

The physiology underlying Roux-en-Y gastric bypass: a status report

Lutz

Bueter

2014

American Journal of Physiology-Regulatory, Integrative and Comp

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Lutz TA, Bueter M. The physiology underlying Roux-en-Y gastric bypass: a status report. Am J Physiol Regul Integr Comp Physiol 307: R1275-R1291, 2014. First published September 24, 2014 doi:10.1152/ajpregu.00185.2014.-Obesity and its related comorbidities can be detrimental for the affected individual and challenge public health systems worldwide. Currently, the only available treatment options leading to clinically significant and maintained body weight loss and reduction in obesity-related morbidity and mortality are based on surgical interventions. This review will focus on two main clinical effects of Roux-en-Y gastric bypass (RYGB), namely body weight loss and change in eating behavior. Animal experiments designed to understand the underlying physiological mechanisms of these post-gastric bypass effects will be discussed. Where appropriate, reference will also be made to vertical sleeve gastrectomy. While caloric malabsorption and mechanical restriction seem not to be major factors in this respect, alterations in gut hormone levels are invariably found after RYGB. However, their causal role in RYGB effects on eating and body weight has recently been challenged. Other potential factors contributing to the RYGB effects include increased bile acid concentrations and an altered composition of gut microbiota. RYGB is further associated with remarkable changes in preference for different dietary components, such as a decrease in the preference for high fat or sugar. It needs to be noted, however, that in many cases, the question about the necessity of these alterations for the success of bariatric surgery procedures remains unanswered.Roux-en-Y gastric bypass; vertical sleeve gastrectomy; gut hormones; restriction; malabsorption; energy expenditure THE OBESITY EPIDEMIC AND ITS related comorbidities constitute a major challenge for both personal health and public health systems worldwide. The enormous increase in knowledge about the physiological mechanisms that control eating and body weight contrasts with the lack of available pharmacological therapies leading to safe, efficient, and long-lasting body weight reductions and amelioration of obesity-related comorbidities. However, recent insights into underlying mechanisms of obesity and bariatric surgery have led to promising perspectives in respect to gut hormone-based strategies against obesity. Nevertheless, best results for maintained weight reduction and improvement of comorbidities are still achieved by surgical means (22,88,121,135,136). This review aims to summarize key findings in respect to underlying physiological mechanisms of the Roux-en-Y gastric bypass (RYGB) procedure, which is the most commonly performed bariatric operation worldwide and thus, by many is considered as the gold standard in bariatric surgery. Sporadic reference will also be made to vertical sleeve gastrectomy (VSG) when appropriate. Both operations reduce eating at least temporarily (19,140,143) and lead to changes in food preferences (20,27,72). The majority of data collected with...

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Section: Energy Expenditurementioning

confidence: 99%

The physiology underlying Roux-en-Y gastric bypass: a status report

Lutz

Bueter

2014

American Journal of Physiology-Regulatory, Integrative and Comp

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“…Dig Surg 2014;31:13-24 DOI: 10.1159/000354319 21 induced changes in energy expenditure [53,[55][56][57][58][59] . Some but not all studies report increases in energy expenditure, but energy expenditure was often measured only over short time periods and then extrapolated to a 24-hour period; hence, true effects induced by RYGB may have been overlooked.…”

Section: Physiological Mechanisms Behind Rygb Surgerymentioning

confidence: 99%

Physiological Mechanisms behind Roux-en-Y Gastric Bypass Surgery

Lutz¹,

Bueter

2014

Dig Surg

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Obesity and its related comorbidities can be detrimental for the affected individual and challenge public health systems worldwide. Currently, the only available treatment options leading to clinically significant and maintained body weight loss and reduction in obesity-related morbidity and mortality are based on surgical interventions. Apart from the 'gold standard' Roux-en-Y gastric bypass (RYGB), the vertical sleeve gastrectomy and gastric banding are two frequently performed procedures. This review will discuss animal experiments designed to understand the underlying mechanisms of body weight loss after bariatric surgery. While caloric malabsorption and mechanical restriction are no major factors in this respect, alterations in gut hormone levels are invariably found after RYGB. However, their causal role in RYGB effects on eating and body weight has recently been challenged. Other potential factors contributing to the RYGB effects include increased bile acid concentrations and an altered composition of gut microbiota. RYGB is further associated with remarkable changes in the preference for different dietary components such as a decrease in the preference for high fat or sugar; it is important to note that the contribution of altered food preferences to the RYGB effects on body weight is not clear. high fat or sugar; it is important to note that the contribution of altered food preferences to the RYGB effects on body weight is not clear.

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“…This technique is the most recommended and used in Brazil and is considered the gold standard procedure for weight loss surgery (9,11) . Patients submitted to gastric bypass should perform blood tests regularly to control possible deficiencies in vitamins and minerals (51) .…”

Section: Age and Gender May Influence The Results Of Roux-en-y Gastrimentioning

confidence: 99%

AGE AND GENDER MAY INFLUENCE THE RESULTS OF ROUX-EN-Y GASTRIC BYPASS? Metabolic syndrome parameters

Andrade-Silva

Caranti

Sallet³

et al. 2014

Arq. Gastroenterol.

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-Context -Severe obesity affects the body favoring the development of serious diseases, including hypertension, diabetes mellitus, atherosclerosis and non alcoholic fatty liver disease. Bariatric procedures increased in Brazil in the last decade. Objectives -The purpose of this study was to verify if gender and age in date of procedure resulted significant differences in metabolic syndrome parameters after surgery. Methods -The study involved 205 medical records of adult patients undergoing Roux-en-Y gastric bypass, stratified by gender and age groups and followed one year by a multidisciplinary team. Results -It was observed significant decrease in body mass index, fasting glucose and insulin at all ages and both genders. Lipid profile showed significant improvements except high density lipoprotein cholesterol. Ectopic fat in the liver has decreased after 6 months in patients classified with steatosis at baseline. Patients classified as hypertensive blood pressure levels decreased 6 months after surgical intervention. Conclusion -Roux-en-Y gastric bypass proved to be an important tool in remission of metabolic syndrome parameters. The reduction of body mass accompanied to decrease in insulin resistance resulted in lower prevalence of comorbidities associated with obesity. The benefits were similar and extended both genders and all age groups between 18 and 65 years old. HEADINGS -Bariatric surgery. Metabolic syndrome X. Roux-en-Y anastomosis. Fatty liver.

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Effects of Roux-en-Y Gastric Bypass on Resting Energy Expenditure in Women

Cited by 54 publications

References 18 publications

The physiology underlying Roux-en-Y gastric bypass: a status report

The physiology underlying Roux-en-Y gastric bypass: a status report

Physiological Mechanisms behind Roux-en-Y Gastric Bypass Surgery

AGE AND GENDER MAY INFLUENCE THE RESULTS OF ROUX-EN-Y GASTRIC BYPASS? Metabolic syndrome parameters

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