Effects of Roux-en-Y operations on glucose homeostasis in obese GK rats

Abstract

Gastric bypass surgery might be effective to treat type 2 diabetes mellitus (T2DM), and Roux-en-Y gastrojejunostomy might be more effective than other operative styles.

Comparison between Roux-en-Y and Duodenal-jejunal Bypass on hyperglycemia improvements in SD rats

“…Duodenal-jejunal bypass is a comparatively new procedure, designed at first as a modification of RYGB to treat only T2DM without affecting weight. RYGB bypasses more than 95% of the stomach and the proximal jejunum [13] while DJB preserves the whole stomach, making it a more "pure" metabolic operation. In this study, in order to evaluate their efficacies, we used SD rats to directly compare these two surgery procedures through indexes including weight, food intake, fasting blood glucose and GLP-1 levels.…”

“…Both procedures bypass the duodenum and the proximal jejunum, enhancing the delivery of undigested nutrients to the ileum [13] . They only vary in the extent of stomach exclusion, as DJB leaves the stomach intact.…”

“…In human patients, RYGB often bypasses 95% of the stomach. But according to Xueli Zhang et al [13] , because of some anatomic factors and difficulties in stapling, in rats RYGB bypasses only 80% of the stomach and the rest 20% gastric pouch was made using a 45 mm GIA stapler (ETS-Flex Ethicon Endosurgery, Blue Ash, OH, USA). After the small intestine was cut off 8 cm from the ligament of Treitz, the smaller pouch was connected to distal jejunum with an end-to-side anastomosis to form an alimentary "Roux" limb.…”