Effects of royal jelly supplementation on regulatory T cells in children with SLE

Zahran, Asmaa M; Elsayh, Khalid I; Saad, Khaled; Eloseily, Esraa M.; Osman, Naglaa S.; Alblihed, Mohamed A.; Badr, Gamal; Mahmoud, Mohamed H.

doi:10.3402/fnr.v60.32963

Cited by 26 publications

(23 citation statements)

References 33 publications

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“…Moreover, CD8 + CD25 +high and CD8 + CD25 +high FOXP3 + cells (CD8 + Treg cells) significantly increased after royal jelly treatment ( p < 0.01). Percentages of CD8 + CD25 +high and CD8 + Treg cells in patients with SLE at baseline (prior to royal jelly treatment) were significantly lower than in the control group of children without SLE ( p = 0.003) ( 197 ).…”

Section: Nutraceuticsmentioning

confidence: 97%

Immunomodulatory Effects of Diet and Nutrients in Systemic Lupus Erythematosus (SLE): A Systematic Review

et al. 2020

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Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple organ involvement, including the skin, joints, kidneys, lungs, central nervous system and the haematopoietic system, with a large number of complications. Despite years of study, the etiology of SLE remains unclear; thus, safe and specifically targeted therapies are lacking. In the last 20 years, researchers have explored the potential of nutritional factors on SLE and have suggested complementary treatment options through diet. This study systematically reviews and evaluates the clinical and preclinical scientific evidence of diet and dietary supplementation that either alleviate or exacerbate the symptoms of SLE. For this review, a systematic literature search was conducted using PubMed, Scopus and Google Scholar databases only for articles written in the English language. Based on the currently published literature, it was observed that a low-calorie and low-protein diet with high contents of fiber, polyunsaturated fatty acids, vitamins, minerals and polyphenols contain sufficient potential macronutrients and micronutrients to regulate the activity of the overall disease by modulating the inflammation and immune functions of SLE.

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Section: Nutraceuticsmentioning

confidence: 97%

Immunomodulatory Effects of Diet and Nutrients in Systemic Lupus Erythematosus (SLE): A Systematic Review

et al. 2020

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“…Immunomodulatory response plays a significant role in allergy, cancer, and inflammation by activation of antibody formation or inhibition of white blood cell activities [132]. The first human study in systemic lupus erythematosus (SLE) in children reveals that the effect of RJ treatment in SLE indicates a significant improvement after three months of administration [133]. The anti-allergic factors of RJ inhibit interleukin-4 (IL-4) production which is induced by anti-CD3 activated spleen cells derived from ovalbumin (OVA)/alum-immunized mice.…”

Section: Immunomodulatory Activitymentioning

confidence: 99%

New Insights into the Biological and Pharmaceutical Properties of Royal Jelly

Ahmad

Campos

Fratini

et al. 2020

IJMS

169

134

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Royal jelly (RJ) is a yellowish-white and acidic secretion of hypopharyngeal and mandibular glands of nurse bees used to feed young worker larvae during the first three days and the entire life of queen bees. RJ is one of the most appreciated and valued natural product which has been mainly used in traditional medicines, health foods, and cosmetics for a long time in different parts of the world. It is also the most studied bee product, aimed at unravelling its bioactivities, such as antimicrobial, antioxidant, anti-aging, immunomodulatory, and general tonic action against laboratory animals, microbial organisms, farm animals, and clinical trials. It is commonly used to supplement various diseases, including cancer, diabetes, cardiovascular, and Alzheimer’s disease. Here, we highlight the recent research advances on the main bioactive compounds of RJ, such as proteins, peptides, fatty acids, and phenolics, for a comprehensive understanding of the biochemistry, biological, and pharmaceutical responses to human health promotion and life benefits. This is potentially important to gain novel insight into the biological and pharmaceutical properties of RJ.

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“…RJ significantly delayed emerging of symptoms, decreased proteinuria, and reduced anti-dsDNA antibody, anti-ssDNA antibody, anti-erythrocyte antibody and splenic autoreactive B cells. In another study on pediatric SLE Ortadoğu Tıp Dergisi / Ortadogu Medical Journal patients, three-month RJ consumption resulted with a particular increase in CD4+ regulatory T cell levels and decrease in apoptotic CD4+ T cell cell levels [65]. Erem et al [66] studied T cell culture for potential effects of RJ on healthy human and patients with Graves disease.…”

Section: Immunologic Activitiesmentioning

confidence: 99%

Royal jelly: a natural therapeutic?

2019

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Royal jelly is a secretion of honeybees that is actually for feeding of bee larvae. It contains many bioactive substances such as jelleins, royalisin, major royal jelly proteins and 10-hydroxy-2-decenoic acid. Recently, many studies were published investigating activities of royal jelly. In overall, royal jelly found to have antioxidant, neurotrophic, antidiabetic, hypocholesterolemic, regulatory on blood pressure, antimicrobial, immunomodulatory, anti-tumor and tissue-protective effects. These activities are strongly related to each other and cannot be evaluated separately. Researchers claim that royal jelly can be an excellent therapeutic agent (or an additional agent), especially in treatments of cancer and metabolic syndrome. However, there are huge gaps due to limited number of in vivo studies and there are standardization issues both for usage and investigations. Furthermore, wide variability of contents in royal jelly due to geographic locations, climate, etc also causes a problem in choice of exact royal jelly. Currently it seems to be safe and effective nutritious agent for healthy people, but it is hard to gain an overall perspective in usage as a therapeutic, since there is a necessity of wider studies with more different types of royal jelly. Sığ et al. / Royal jelly 334 ORTADOGU TIP DERG 2019; 11(3): 333-341 ÖZ Arı sütü aslen arı larvalarının beslenmesi için bal arıları tarafından üretilen bir sekresyondur. Jelleinler, royalizin, ana arı sütü proteinleri ve 10-hidroksi-2-desenoik asit gibi çok sayıda biyoaktif madde içermektedir. Son yıllarda arı sütü konusunda çok sayıda makale yayımlanmıştır. Genel olarak, arı sütü, antioksidan, nörotropik, antidiyabetik, hipokolesterolemik, kan basıncı düzenleyici, antimikrobiyal, immünomodülatör, anti-tümör ve doku koruyucu etkileri göstermektedir. Bu etkiler aslen bir bütündür ve mekanizmaları ayrı ayrı değerlendirmek mümkün değildir. Araştırmacılar, özellikle kanser ve metabolik sendrom tedavisinde iyi bir tedavi ajanı (veya tedaviye ek bir ajan) olabileceğini iddia etmektedir. Öte yandan, in vivo çalışmaların sayısı son derece sınırlıdır ve hem araştırma hem kullanım alanlarında standardizasyon sorunu vardır. Ayrıca, coğrafi konum, iklim gibi koşullara bağlı olarak arı sütü içeriğinin ciddi farklılıklar göstermesi, arı sütünün seçiminde sorunlar yaratmaktadır. Şu an için, sağlıklı insanlarda güvenli ve etkin bir besleyici gıda olarak gözükmekte, fakat terapötik kullanımı konusunda genel bir görüş elde etmek mümkün gözükmemektedir. Farklı türlerde arı sütleri üzerinde daha geniş çaplı araştırmalar yapılmalıdır.Anahtar kelimeler: arı sütü, apiterapi, arı ürünleri, biyofarmasötik ajanlar, geleneksel ve tamamlayıcı tıp

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Effects of royal jelly supplementation on regulatory T cells in children with SLE

Cited by 26 publications

References 33 publications

Immunomodulatory Effects of Diet and Nutrients in Systemic Lupus Erythematosus (SLE): A Systematic Review

Immunomodulatory Effects of Diet and Nutrients in Systemic Lupus Erythematosus (SLE): A Systematic Review

New Insights into the Biological and Pharmaceutical Properties of Royal Jelly

Royal jelly: a natural therapeutic?

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