Workers’ wellbeing and safety is important in the construction industry due to the high risk of accidents. Safety climate development is a positive initial step toward raising the safety levels of construction practitioners. This study aims at revealing the factors influencing safety climate perceptions in the construction industry of Saudi Arabia. A set of extracted factors from the literature was validated and used to design a comprehensive questionnaire survey. Data was collected from 401 personnel working on 3 large construction project sites in Saudi Arabia. Descriptive statistics and the crosstabulation algorithm, Kendall’s tau-b correlation test, were used to analyze the data. The study revealed a set of 13 factors influencing safety climate perceptions, which are: Supervision, guidance and inspection, appraisal of risks and hazards, social security and health insurance, workmate influences, management safety justice, management commitment to safety, education and training, communication, workers’ safety commitment, workers’ attitude toward health and safety, workers’ involvement, supportive environment, and competence. The results also indicate the significant and anticipated role of top management in safety climate at sites. Implications of this study include assisting construction industry stakeholders to better understand and enhance safety climate, which in turn will lead to improved safety behavior, culture, motivation, and performance.