Effects of Salbutamol and Isoprenaline Phenylephrine in Reversible Airways Obstruction

Abstract

S39 examination showed delayed gastric emptying with a lesser curve gastric ulcer. Acid secretory studies showed no response to insulin, indicating a complete vagotomy. At reoperation, eight months after the first operation, a lesser curve gastric ulcer was present but no duodenal ulcer. He is now well after antrectomy.Case 3.-An insulin test was negative three months after vagotomy in a man aged 37. After one year he developed epigastric pain and vomiting and barium meal examination showed a lesser curve gastric ulcer with normal gastric emptying. The ulcer was confirmed by gastroscopy. Conservative treatment of the ulcer was undertaken and further gastroscopy showed that the ulcer was healing. Fourteen months after the operation and two months after the development of a gastric ulcer a barium meal examination showed an apparently normal stomach which still emptied normally. He was then symptom-free. DiscussionThe idea of treating patients with duodenal ulceration by vagotomy without a drainage operation is attractive and has been the goal of many surgeons. Dragstedt and Owens (1943) Jrournal, 1972, 1, 539-542 Summary Ventolin (salbutamol) and Medihaler-Duo (isoprenaline/ phenylephrine combination) standard pressurized inhalers were used to administer doses of two or six "puffs" to 16 patients with known reversible airways obstruction.The doses were administered in random order over two days. Both the Ventolin and Medihaler-Duo inhalers substantially increased FEV1, but in the doses used salbutamol was more effective than isoprenaline/phenylephrine (P < 001). There was no significant difference between two and six puffs of salbutamol, though there seemed to be an advantage of six puffs of isoprenaline/ phenylephrine over two puffs (P < 0 05). Adrenaline (1/1,000) 0 5 ml and atropine 0 6 mg produced similar increases in FEV1 to those produced by salbutamol.County Hospital, Hereford R.

Clinical assessment of bronchodilator drugs delivered by aerosol

“…Further problems arise when considering what measurements to make and how to express the results. These difficulties have recently been summarized by Alliott, Lang, Rawson, and Leckie (1972).We have developed a simple and reproducible method for assessing new aerosol bronchodilator drugs, which overcomes many of the difficulties and provides useful additional information even with only a small number of patients. We describe here the results obtained with three new sympathomimetic drugs, Th 1165a, salmefamol, and rimiterol, using this method.…”

A Comparison of Rimiterol and Salbutamol by Inhalation at High and Low Dose in Asthmatic Patients

“…These results are different from those of Phillips et al [11] who, using normal subjects, found significant increases in heart rate after salbutamol 1,000 /<g, the same dose as in the present experiment but not after 1,000/¿g of rimiterol. In contrast, Alliott et al [10] in their study of asthmatic patients, found significant increases in heart rate after salbutamol 600 ug given by aero sol but not after the same drug was given at the lower, 'recommended' dose of 200 ug.…”

“…In addition, there is evidence that spe cificity for /(¡¡-receptors may be lost with in-creasing dosage of inhaled sympathomimet ic bronchodilators [9,10]. Therefore, in our recent investigation of rimiterol (Pulmadit®) -a new selective /J-adrenoreceptor-stimulant aerosol preparation -we ar ranged our trial to compare the effects of rimiterol with those of salbutamol at 'rec ommended' (low) and 5-10 times 'recom mended' (high) dosages.…”

A Brief Review of Sympathomimetic Bronchodilators and a Description of a New Selective Agent, Rimiterol Hydrobromide

“…Hoi gate and Tattersfield [41] claim to have demonstrat ed bronchial adrenoreceptor resistance in normal subjects but this requires confirma tion in patients. However, there is evidence that 'specificity' for //¡-adrenoreceptors may be lost with higher doses of the newer /?»-selective bronchodilator drugs; Alliott et al [42] , Cooke et al [29], and Phillips et al…”