The present study was conducted to assess modulation in morpho-physiological attributes of rice (Oryza sativa L.) cultivars (Bas-385, Bas-2000, Bas-370 and Shaheen) at vegetative stage by phospholipase C (PLC) inhibitor neomycine (control and 100 µM) under salt stress (control, 50, 100 and 150 mM NaCl). Salt stress significantly reduced shoot fresh and dry weights, shoot length, water potential, osmotic potential, net CO 2 assimilation rate (A), transpiration rate (E), stomatal conductance (g s ), non-photochemical quenching (NPQ), coefficient of non-photochemical quenching (q N ) and photochemical quenching (q P ) while increased efficiency of photosystem-II (Fv/Fm), leaf free proline, shoot and root Na . Of all rice cultivars, cv. Bas-2000 performed better in growth, water relation and photosynthetic attributes under saline and non-saline conditions.