Effects of salmon calcitonin suppositories in the prevention of bone loss in oophorectomized women

Polatti, Franco; Perotti, F; Angelini, G.; Vassellatti, D.; Rapisardi, I.

doi:10.1016/0378-5122(93)90031-c

Cited by 9 publications

(1 citation statement)

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“…Similar to the nasal spray, this effect was evident at the spine, but it was not so clear at the forearm, even though a significant inhibition of bone turnover was obtained during the study. Unfortunately, there was a dropout rate of 23%, which is almost the same as for the parenteral preparations, and although positive results have been also reported in another study on ovariectomized women [34], calcitonin suppositories do not appear to offer any advantage compared to nasal or oral formulations.…”

Section: Oral and Enteral Formulationsmentioning

confidence: 83%

Calcitonin in Osteoporosis

Civitelli

2013

Osteoporosis

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Section: Oral and Enteral Formulationsmentioning

confidence: 83%

Calcitonin in Osteoporosis

Civitelli

2013

Osteoporosis

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The effect of bilateral oophorectomy on bone mineral density

Hayirlioglu¹,

Gökaslan

Andaç³

2006

Rheumatol Int

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The objective of this study is to investigate the effect of bilateral oophorectomy with total abdominal hysterectomy on bone loss, comparing the cases having surgery before and after the menopause. Bone mineral density (BMD) measurements were obtained from the lumbar spine and femoral neck of totally 127 cases. Out of 127, 105 had surgery before menopause and 22 cases were operated on postmenopausally. The results were compared with the USA normal values. The average age of surgical menopause (SM) cases was 48.45 years with a mean duration of menopause of 5.77 years. The average height and weight were 157.67 cm and 68.19 kg, respectively. The average age of cases having surgery after menopause (SAM) was 62.45 years with a mean duration of 5.59 years after the surgery (duration after menopause is 13.23 years). The average height and weight were 157.45 cm and 73.55 kg, respectively. The average of BMD measurements of lumbar spines L2-L4 was 1.04 gr/cm(2) (BMD = 85.65% and T score = -0.96) in the cases with SM. On the contrary, the average of the BMD measurements of lumbar spines L2-L4 was 1.05 gr/cm(2) (BMD = 101.14% and T score = 0.24) in the cases with SAM. The average of the BMD measurements of femoral neck was 0.85 gr/cm(2) (BMD = 91.39% and T score = -0.64) in the cases with SM. On the contrary, the average of the BMD measurements of femoral neck was 0.82 gr/cm(2) (BMD = 96.69% and T score = -0.31) in the cases with SAM. The bilateral oophorectomy as a surgical procedure is not a statistically significant factor for the acceleration of the bone loss. The main points are the age and the duration of menopause of the patient affecting the bone loss if the surgery is performed before menopause.

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