Effects of Sanguinarine and Chelerythrine on the Cell Cycle and Apoptosis

Malíková, J.; Zdařilová, Adéla; Hlobílková, Alice

doi:10.5507/bp.2006.001

Cited by 91 publications

(55 citation statements)

References 50 publications

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“…In detail, the sanguinarine-induced apoptosis occur either via a mithocondrial pathway dependent on caspase-9 or by the DR pathways, with the activation of caspase 8. The activation of caspase 3, which represents a key factor for apoptosis execution in both pathways, and the following cleavage of PARP together with the down-regulation of Bcl-2 and c-FLIP, may play a very important role in the apoptosis induced by sanguinarine [26,51,52] . Studies performed in human neuroblastoma cells SH-SY5Y have shown that sanguinarine reduces the expression of anti-apoptotic genes, particularly of NOL3, BCL2, and HRK genes [45] .…”

Section: Sanguinarine Induces Apoptosis In Tumor Cellsmentioning

confidence: 99%

Antitumor effects of the benzophenanthridine alkaloid sanguinarine: Evidence and perspectives

Gaziano

Moroni

Buè

et al. 2016

WJGO

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Historically, natural products have represented a significant source of anticancer agents, with plant-derived drugs becoming increasingly explored. In particular, sanguinarine is a benzophenanthridine alkaloid obtained from the root of Sanguinaria canadensis , and from other poppy Fumaria species, with recognized anti-microbial, anti-oxidant and anti-inflammatory properties. Recently, increasing evidence that sanguinarine exibits anticancer potential through its capability of inducing apoptosis and/or antiproliferative effects on tumor cells, has been proved. Moreover, its antitumor seems to be due not only to its pro-apoptotic and inhibitory effects on tumor growth, but also to its antiangiogenic and anti-invasive properties. Although the precise mechanisms underlying the antitumor activity of this compound remain not fully understood, in this review we will focus on the most recent findings about the cellular and molecular pathways affected by sanguinarine, together with the rationale of its potential application in clinic. The complex of data currently available suggest the potential application of sanguinarine as an adjuvant in the therapy of cancer, but further pre-clinical studies are needed before such an antitumor strategy can be effectively translated in the clinical practice.

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Section: Sanguinarine Induces Apoptosis In Tumor Cellsmentioning

confidence: 99%

Antitumor effects of the benzophenanthridine alkaloid sanguinarine: Evidence and perspectives

Gaziano

Moroni

Buè

et al. 2016

WJGO

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“…IQAs-mediated apoptosis has been found in human cancer through their activation of caspase-3 and depletion of GSH [106] [176]. IQAs were found to result in increased levels of cytochrome c and Apaf-1 and in a significant increase in the active form of caspases 3, 7, 8, and 9 in a dose-dependent manner in many cancer cells [174] [177]- [180].…”

Section: Isoquinoline Alkaloidsmentioning

confidence: 99%

Natural Products Modulate the Multifactorial Multidrug Resistance of Cancer

Eid¹,

El-Readi²,

Fatani³

et al. 2015

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“…The mechanism of action of benzophenanthrid alkaloids is associated with the cell death signaling pathway, and apoptosis induction is shown in various cancer cell lines. Apoptosis caused by sanguinarine has been shown through different ways, such as mitochondrial damage, nuclear factor kappa-light-chain enhancer of activated B cells activation, and cell cycle arrest [2] . Sanguinarine is shown to inhibit microtubule polymerization and can intercalate double-stranded DNA [3,4] .…”

Section: Introductionmentioning

confidence: 99%

Apoptotic Effects of Sanguinarine on the Organ of Corti 1 Cells: Comparison with Cisplatin

Çeçen¹,

Erçetin²,

Kırkım³

et al. 2015

Int Adv Otol

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OBJECTIVE:Sanguinarine is an alkaloid obtained from the root of Sanguinaria canadensis and other plants from the Papaveraceae family and is well known to possess a broad range of biological functions, such as antimicrobial, antifungal, anti-inflammatory, and antineoplastic activities. We aimed to specify the in vitro effect of sanguinarine on the House Ear Institute-Organ of Corti 1 (HEI-OC1) cells and to compare this effect with the ototoxic effect of cisplatin (CDDP). MATERIALS and METHODS:We performed cell proliferation assay for determining the in vitro effect of sanguinarine alone and compared it with the effect of cisplatin. Flow cytometry annexin-V apoptosis detection was performed. RESULTS:We found that sanguinarine and CDDP inhibited the cell growth in a dose-dependant manner in HEI-OC1 cells after 24 h of incubation. In sanguinarine-treated group, apoptosis was 6.6%, necrosis was 26.7%, and the cell viability was 66.7%. Further, in CDDP-treated group, apoptosis was 5.6%, necrosis was 45.4%, and the cell viability was 48.7%. According to the annexin-V apoptosis detection results, we found that sanguinarine caused 3.9% apoptosis and 1.3% necrosis, while CDDP caused 2.9% apoptosis and 20% necrosis on HEI-OC1 cells. CONCLUSION:Our findings suggested that lower doses of sanguinarine are promising antineoplastic agents, which did not indicate any toxic effect on HEI-OC1 cells. Application of these data to clinical practice requires further support by in vivo studies.

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Effects of Sanguinarine and Chelerythrine on the Cell Cycle and Apoptosis

Cited by 91 publications

References 50 publications

Antitumor effects of the benzophenanthridine alkaloid sanguinarine: Evidence and perspectives

Antitumor effects of the benzophenanthridine alkaloid sanguinarine: Evidence and perspectives

Natural Products Modulate the Multifactorial Multidrug Resistance of Cancer

Apoptotic Effects of Sanguinarine on the Organ of Corti 1 Cells: Comparison with Cisplatin

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