Effects of sc Administration of Recombinant Human Insulin-Like Growth Factor I (IGF-I) on Normal Human Subjects.

Takano, Kazue; Hizuka, Naomi; Asakawa, Kumiko; Sukegawa, Izumi; Shizume, Kazuo; Demura, Hiroshi

doi:10.1507/endocrj1954.37.309

Cited by 28 publications

(23 citation statements)

References 20 publications

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“…IGF bioactivity measures the net stimulatory effect of a system and is likely to be a reflection of absolute levels of the IGFs and their relative distribution on the binding proteins. Levels of 'free' IGF-I were not greatly elevated with the dose of rhIGF-I used in this study and it is interesting to note that in normal subjects a dose of 100 µ/kg only produced free levels in the order of 9% (Takano et al 1991).…”

Section: Discussionmentioning

confidence: 56%

The effects of recombinant human insulin-like growth factor-I (IGF-I) administration on the levels of IGF-I, IGF-II and IGF-binding proteins in adolescents with insulin-dependent diabetes mellitus

Cheetham

Taylor²,

Holly³

et al. 1994

Journal of Endocrinology

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Insulin-dependent diabetes mellitus (IDDM) during puberty is associated with a reduction in circulating concentrations of insulin-like growth factor-I (IGF-I) and low IGF bioactivity. Altered levels of the IGF-binding proteins (IGFBPs), including low IGFBP-3 and elevated IGFBP-1, have also been described. These abnormalities have been linked to poor growth and deteriorating blood glucose control. We have therefore examined the effects of recombinant human IGF-I (rhIGF-I) administration on the levels of IGF-I, IGF-II, IGFBP-1, IGFBP-3 and IGF bioactivity in a group of 9 late-pubertal adolescents with IDDM. This was a double-blind placebo controlled study with each individual admitted on two occasions when either rhIGF-I (40 micrograms/kg) or placebo was administered by subcutaneous injection in the thigh at 1800 h. Blood samples were then taken for the subsequent 22 h. The half-life of administered rhIGF-I (12.1-22.2 h) was similar to that previously described in normal subjects. There was a small increase in IGFBP-3 concentrations overnight following rhIGF-I administration when compared to placebo, whereas the levels of IGF-II decreased. Under strict euglycaemic conditions, the relationship between insulin and IGFBP-I did not appear to be affected by rhIGF-I administration although the levels of IGFBP-1 tended to be higher overnight. IGF bioactivity was low during the placebo study, and although within the normal adult range following administration of IGF-I, was still relatively low for adolescents in late puberty.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionmentioning

confidence: 56%

The effects of recombinant human insulin-like growth factor-I (IGF-I) administration on the levels of IGF-I, IGF-II and IGF-binding proteins in adolescents with insulin-dependent diabetes mellitus

Cheetham

Taylor²,

Holly³

et al. 1994

Journal of Endocrinology

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“…Under physiological conditions, the plasma level of IGF-I is almost constant all day long, and the serum IGF-I concentration extracted with acid-ethanol is around 200 ng/ml (Takano et al, 1990a). Less than 5 percent of the total serum IGF-I seems to be an active form freed from its binding protein (Hizuka et al submitted for publication).…”

Section: Discussionmentioning

confidence: 99%

“…Recombinant human IGF-I infused into hypophysectomized rats and insulin deficient diabetic rats stimulated their growth (Schoenle et al, 1982;Scheiwiller et al, 1986). However, it also exerts metabolic actions that closely resemble those of insulin; IGF-I caused a decrease in plasma glucose and insulin levels in animals and man (Zapf et al, 1986;Guler et al, 1989;Takano et al, 1990a). The results with the glucose clamp technique in rats suggest that the decrease in plasma insulin is derived from the direct effect of IGF-I on insulin secretion from islet B-cells (Jacob et al, 1989).…”

mentioning

confidence: 99%

Effects of Insulin-Like Growth Factor-I on Insulin and Glucagon Release from Isolated Perfused Rat Pancreas.

Kawai

Suzuki

Takano³

et al. 1990

Endocrinol Japon

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The infusion of recombinant insulin-like growth factor I (IGF-I) causes a decrease in plasma glucose and insulin. In this study we examined whether or not IGF-I directly affects islet hormone release by means of a rat pancreas perfusion system. A superphysiologic concentration of IGF-I (2nM) elicited a slight but significant decrease in insulin release under the perfusate glucose concentration of 120mg/dl. A pharmacological concentration of IGF-

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“…In humans, undergoing chronic IGF-I-administration, the urinary sodium and potassium excretions are transiently decreased [81,92], but unchanged after weeks of treatment [81,87,93], thus following the pattern of GH.…”

Section: Effects Of Gh On Urinary Electrolyte Excretion and Urinary Vmentioning

confidence: 99%

Acute and chronic effects of growth hormone on renal regulation of electrolyte and water homeostasis

Dimke

Flyvbjerg

Frische

2007

Growth Hormone & IGF Research

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Effects of sc Administration of Recombinant Human Insulin-Like Growth Factor I (IGF-I) on Normal Human Subjects.

Abstract: Recombinant human insulin-like growth factor

Cited by 28 publications

References 20 publications

The effects of recombinant human insulin-like growth factor-I (IGF-I) administration on the levels of IGF-I, IGF-II and IGF-binding proteins in adolescents with insulin-dependent diabetes mellitus

The effects of recombinant human insulin-like growth factor-I (IGF-I) administration on the levels of IGF-I, IGF-II and IGF-binding proteins in adolescents with insulin-dependent diabetes mellitus

Effects of Insulin-Like Growth Factor-I on Insulin and Glucagon Release from Isolated Perfused Rat Pancreas.

Acute and chronic effects of growth hormone on renal regulation of electrolyte and water homeostasis

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